Article
Biochemistry & Molecular Biology
Ana Bocanegra, Gonzalo Fernandez-Hinojal, Daniel Ajona, Ester Blanco, Miren Zuazo, Maider Garnica, Luisa Chocarro, Elvira Alfaro-Arnedo, Sergio Pineiro-Hermida, Pilar Morente, Leticia Fernandez, Ana Remirez, Miriam Echaide, Maite Martinez-Aguillo, Idoia Morilla, Beatriz Tavira, Alejandra Roncero, Carolina Gotera, Alfonso Ventura, Nerea Recalde, Jose G. Pichel, Juan Jose Lasarte, Luis Montuenga, Ruth Vera, Ruben Pio, David Escors, Grazyna Kochan
Summary: Recent studies show that baseline functional immunity is crucial for the success of immune checkpoint blockade therapies. In this study, high-dimensional systemic immune profiling was performed on non-small-cell lung cancer patients undergoing PD-L1/PD-1 blockade immunotherapy. Responders had a higher diversity of myeloid phenotypes in their peripheral blood. A diversity index was defined as a potential biomarker of response. Fractalkine (FKN), a chemokine linked to immune chemotaxis and adhesion, was identified as a biomarker of response and correlated with myeloid cell diversity. FKN inhibited lung adenocarcinoma growth in both human and mouse models through the involvement of systemic effector NK cells and increased tumor immune infiltration. FKN also sensitized mouse lung cancer models resistant to anti-PD-1 treatment to immunotherapy, indicating its potential therapeutic use in combination with immunotherapy.
Article
Oncology
Ganji Purnachandra Nagaraju, Rama Rao Malla, Riyaz Basha, Ion G. Motofei
Summary: This review provides up-to-date information on the role of PD-1 and PD-L1 in the development of immune tolerance in pancreatic cancer and discusses current clinical trials and known outcomes. It also explores the involvement of PD-1/PD-L1 signaling in pancreatic cancer stem cells and metastasis. The review reviews the safety, tolerance, and efficacy of clinically important regimens of PD-1/PD-L1 blocking agents and targeted therapeutics.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Changsheng Huang, Shengxiang Ren, Yaqi Chen, Anyi Liu, Qi Wu, Tao Jiang, Panjing Lv, Da Song, Fuqing Hu, Jingqing Lan, Li Sun, Xue Zheng, Xuelai Luo, Qian Chu, Keyi Jia, Yan Li, Jun Wang, Caicun Zou, Junbo Hu, Guihua Wang
Summary: This research discovered that PD-L1 K162 was methylated by SETD7 and demethylated by LSD2. Additionally, PD-L1 K162 methylation controlled the PD1/PD-L1 interaction and significantly enhanced the suppression of T cell activity in controlling cancer immune surveillance. The study demonstrated that PD-L1 hypermethylation was the key mechanism for anti-PD-L1 therapy resistance, identified PD-L1 K162 methylation as a negative predictive marker for anti-PD-1 treatment in patients with non-small cell lung cancer, and showed that the PD-L1 K162 methylation:PD-L1 ratio was a more accurate biomarker for predicting anti-PD-(L)1 therapy sensitivity.
Review
Oncology
Seri Jeong, Nuri Lee, Min-Jeong Park, Kibum Jeon, Wonkeun Song
Summary: This study reviewed laboratory techniques for detecting the PD-1 axis in metastatic breast cancer patients undergoing immunotherapy and highlighted the impact of variations in assay methods on result interpretation and clinical utility. The development of new methodologies for assessing PD-L1 expression and soluble PD-L1 has provided more accessible and non-invasive options for monitoring immune checkpoint levels in patients.
Review
Immunology
Mengke Niu, Yiming Liu, Ming Yi, Dechao Jiao, Kongming Wu
Summary: The immune checkpoint pathway involving PD-1 and PD-L1 plays a crucial role in inhibiting T-cell proliferation and function, affecting antitumor immune responses. Alternative forms of PD-1/PD-L1, such as sPD-1/sPD-L1 and exoPD-L1, have been detected in cancer patients and may have significant biological activities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Wu, Yingjie Xu, Xujun Li, Huina Liu, Tianzi You, Ting Cai, Fan Yang
Summary: This study found that PD-1 is aberrantly upregulated in TNBC patients and cell lines. Cell-intrinsic PD-1 in TNBC cells significantly facilitated tumor growth and metastasis through the cell-intrinsic PD-1/PD-L1 pathway, which is regulated by the gene expression regulator YB-1. Silencing YB-1 expression in TNBC cells inhibits cell proliferation, tumorigenesis, and metastasis, and this inhibition can be rescued by simultaneous exogenous expression of PD-1 and PD-L1 proteins.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Oncology
Maryam Nakhjavani, Sarah Shigdar
Summary: The treatment of breast cancer that spreads to the brain is challenging due to the brain's protective membrane. This study explores the potential of drug candidates derived from plants and traditional herbal medicines to activate the immune system and kill cancer cells in the brain.
Article
Immunology
Kai Liu, Hui-Huang Huang, Tao Yang, Yan-Mei Jiao, Chao Zhang, Jin-Wen Song, Ji-Yuan Zhang, Chun-Bao Zhou, Jin-Hong Yuan, Wen-Jing Cao, Xiu-Ying Mu, Ming-Ju Zhou, Hua-Jie Li, Ming Shi, Ruonan Xu, Fu-Sheng Wang
Summary: Neutrophils in HIV-1 infection undergo aging and over-aggregation, leading to T cell dysfunction. Dampening neutrophil aging may provide a novel approach to recover T cell dysfunction in patients with HIV-1 infection. So it's important to study the dynamics of neutrophil aging and its relationship with T cell exhaustion.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Florus C. de Jong, Vera C. Rutten, Tahlita C. M. Zuiverloon, Dan Theodorescu
Summary: PD-1/PD-L1 immune checkpoint inhibitors show promise in high-risk non-muscle invasive bladder cancer and muscle-invasive bladder cancer, but challenges such as biomarkers for response stratification and potentially synergistic combination therapy regimens with PD-1/PD-L1 blockade need to be addressed to improve patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Enrico Munari, Francesca R. Mariotti, Linda Quatrini, Pietro Bertoglio, Nicola Tumino, Paola Vacca, Albino Eccher, Francesco Ciompi, Matteo Brunelli, Guido Martignoni, Giuseppe Bogina, Lorenzo Moretta
Summary: Immune evasion is a crucial strategy adopted by tumor cells to promote survival and metastasis, with PD-1 playing a major role in inhibiting immune responses. Targeting the PD-1/PD-L1 axis has been a significant breakthrough in cancer treatment, representing unprecedented success in various cancer types. Further research on mechanisms regulating PD-1 expression and signaling in tumors is needed to improve therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Samia S. Messeha, Najla O. Zarmouh, Karam F. A. Soliman
Summary: Research on dietary polyphenolic compounds as antitumor agents is increasing due to the link between immunity and cancer. These compounds affect cancer progression and metastasis by inhibiting the EMT process, potentially reducing the risk of breast cancer.
Review
Oncology
Laure Chardin, Alexandra Leary
Summary: Ovarian cancer is a highly lethal gynecologic malignancy with a high recurrence rate, despite many patients responding effectively to current treatments. In order to improve outcomes, further research into the immune microenvironment and the development of effective therapies are urgently needed.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Mateusz Kciuk, Damian Kolat, Zaneta Kaluzinska-Kolat, Mateusz Gawrysiak, Rafal Drozda, Ismail Celik, Renata Kontek
Summary: The application of immunotherapy for cancer treatment is expanding rapidly. Combining immunotherapeutic agents with different treatments can enhance the clinical response in patients who have developed resistance to monotherapy. Chemotherapeutic drugs that induce DNA damage often increase the expression of PD-L1, which can be used by cancer cells to evade immune surveillance. Targeting PD-L1 on cancer cells can restore the immune-reactive tumor microenvironment, making the tumor more susceptible to combined therapies. This review discusses the recent advances in understanding how DDR regulates PD-L1 expression and the impact of certain chemotherapeutic drugs on the anti-tumor immune response.
Review
Biochemistry & Molecular Biology
Hikaru Nanamori, Yu Sawada
Summary: Malignant melanoma is a skin cancer with unfavorable clinical behavior, and immunotherapy is currently used for treatment. However, not all patients can benefit from this therapy. To overcome this limitation, clinicians have focused on epigenetic modification, which may have additional therapeutic efficacy by regulating gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Fangyuan Zhang, Jieying Zhang, Lei Zhao, Menglan Zhai, Tao Zhang, Dandan Yu
Summary: This case suggests that even PD-L1 negative gastric cancer patients may benefit from immune checkpoint blockade, especially those with lymph node metastasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tamir Zelter, Jacob Strahilevitz, Karina Simantov, Olga Yajuk, Yvonne Adams, Anja Ramstedt Jensen, Ron Dzikowski, Zvi Granot
Summary: Neutrophils can recognize and kill blood-stage Plasmodium falciparum, with neutrophil ICAM-1 and specific PfEMP1 implicated in cerebral malaria being key molecules involved in this killing.
Review
Immunology
Daniela F. Quail, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andres Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Irina A. Udalova, Timo K. van den Berg, Denisa D. Wagner, Ping Wang, Arturo Zychlinsky, Karin E. de Visser, Mikala Egeblad, Paul Kubes
Summary: This article discusses the functional states and heterogeneity of neutrophils in cancer and provides a consensus statement on the controversies and solutions in neutrophil research. Further research is needed to understand the role of neutrophils in cancer and explore potential novel opportunities for cancer treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ronit Vogt Sionov, Chrystelle Lamagna, Zvi Granot
Summary: This study identifies the mechanism of interaction between neutrophils and tumor cells, showing that the interaction between Cathepsin G on neutrophil surface and tumor RAGE, as well as the involvement of C-type lectin receptors, contribute to neutrophil-mediated cytotoxicity towards tumor cells.