Article
Oncology
Liana C. Arnaud, Thierry Gauthier, Augustin Le Naour, Saleha Hashim, Nathalie Naud, Jerry W. Shay, Fabrice H. Pierre, Elisa Boutet-Robinet, Laurence Huc
Summary: The study found that long-term exposure to food contaminants may have a potential promoting effect on colorectal cancer occurrence and development, affecting cellular mechanisms depending on genetic susceptibility.
Article
Biochemistry & Molecular Biology
Mayes Alswady-Hoff, Johanna Samulin Erdem, Santosh Phuyal, Oskar Knittelfelder, Animesh Sharma, Davi de Miranda Fonseca, Oivind Skare, Geir Slupphaug, Shanbeh Zienolddiny
Summary: This study investigated the long-term effects of TiO2 exposure on pulmonary epithelial cells in vitro, revealing that TiO2 exposure altered the cell cycle, increased apoptosis, and led to lipid accumulation related to cellular stress response. The findings suggest that cell stress response and cell death pathways may play a crucial role in the long-term health effects of TiO2 exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jan Philipp Kolman, Laia Pagerols Raluy, Ingo Mueller, Viacheslav O. Nikolaev, Magdalena Trochimiuk, Birgit Appl, Hannah Wadehn, Charlotte Maria Duecker, Fabian David Stoll, Michael Boettcher, Konrad Reinshagen, Julian Trah
Summary: In this study, the researchers investigated the effect of different culture conditions, including the use of G-CSF, LPS, or TNF-alpha, on the survival and NET formation of neutrophils. They found that untreated neutrophils could form NETs after stimulation with PMA for up to 24 hours. Incubation with LPS or G-CSF extended the ability of neutrophils to form NETs for up to 48 hours, with LPS leading to significantly higher NET release at 48 hours compared to untreated cells. TNF-alpha had no influence on NET release but altered the survival counts of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Elizabeth R. Volkmann, Donald P. Tashkin, Michael D. Roth, Jonathan Goldin, Grace H. J. Kim
Summary: This study demonstrates that short-term changes in radiographic measures of interstitial lung disease (ILD) can predict long-term survival in patients with systemic sclerosis (SSc), indicating that radiographic end points may serve as surrogates for mortality in SSc-ILD.
Article
Developmental Biology
Daniel Castranova, Bakary Samasa, Marina Venero Galanternik, Aniket Gore, Allison E. Goldstein, Jong S. Park, Brant M. Weinstein
Summary: The zebrafish has become a widely used animal model due to its accessibility to and usefulness for high-resolution optical imaging. Although historically focused on early development, it is increasingly being used to study processes in juvenile and adult animals. However, imaging of live adult zebrafish is extremely challenging.
Article
Toxicology
Ryota Shizu, Mai Ishimura, Sumihito Nobusawa, Takuomi Hosaka, Takamitsu Sasaki, Satoru Kakizaki, Kouichi Yoshinari
Summary: The activation of PXR does not promote hepatocarcinogenesis in mice, but rather attenuates CAR-mediated liver cancer development by suppressing the EMT of liver cancer cells.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keiichi Hiramoto, Sayaka Kubo, Keiko Tsuji, Daijiro Sugiyama, Hideo Hamano
Summary: In this study, the effect of long-term blue light exposure on the induction of skin cancer was investigated. It was found that skin cancer was induced only in mice exposed to blue light, and blue light exposure also increased the migration of neutrophils and macrophages involved in carcinogenesis. These findings suggest that long-term exposure to blue light can induce neutrophil NETosis and an increase in type 1 macrophages, leading to skin cancer.
Article
Multidisciplinary Sciences
Mahsa Fardisi, Kyan Thelen, Allegra Groenendal, Mrigendra Rajput, Kimberly Sebastian, G. Andres Contreras, Adam J. Moeser
Summary: Early weaning and biological sex impact long-term immune responses in pigs, with increased neutrophil to lymphocyte ratio and enhanced neutrophil trafficking to the peritoneal cavity.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Seungwon Lee, Dae Hee Pyo, Woo Seog Sim, Woo Young Lee, MiHye Park
Summary: Propofol anesthesia showed lower postoperative neutrophil-lymphocyte ratio compared to sevoflurane anesthesia in colorectal cancer surgery patients, but no significant differences were observed in clinical outcomes between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
L. A. Cagle, A. L. Linderholm, L. M. Franzi, J. A. Last, S. I. Simon, N. J. Kenyon, R. W. Harper
Summary: This study suggests that DUOX is required for CD18-independent mechanisms of neutrophil recruitment in acute lung injury induced by ventilator-induced lung injury, but not for canonical CD18-dependent mechanisms after lipopolysaccharide exposure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Xin Sun, Min Peng, Ting Zhang, Zongru Li, Lan Song, Mengtao Li, Juhong Shi
Summary: This study compared the clinical features and outcomes between MPA-associated ILDs and isolated ANCA-positive IIPs. It found that MPA-ILD patients had higher fever rates and inflammatory markers compared to ANCA-IIP patients. Elevated erythrocyte sedimentation rate was identified as an independent risk factor for mortality in ANCA-positive ILDs patients. Additionally, the prognosis of ANCA-IIPs with normal inflammation markers, those with elevated markers, and MPA-ILDs were sequentially poorer, highlighting the need for stratified treatment in managing ILDs patients positive for ANCAs.
BMC PULMONARY MEDICINE
(2021)
Review
Immunology
Cynthia L. Miller, M. O. M. Jane, James S. Allan, Joren C. Madsen
Summary: Allograft failure in lung transplantation is a major barrier, and standard immunosuppressive regimens have not been successful. Recent research on the mechanisms of lung allograft rejection has led to the development of new strategies to promote long-term graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Richard Hardstone, Michael Zhu, Adeen Flinker, Lucia Melloni, Sasha Devore, Daniel Friedman, Patricia Dugan, Werner K. Doyle, Orrin Devinsky, Biyu J. He
Summary: This passage discusses the influence of prior experiences on perception and the neural mechanisms observed in experiments. When perception is congruent with prior, there is increased top-down input, while stronger feedforward drive is observed when perception is incongruent with prior. The study results indicate a pattern of large-scale information flow change underlying the influence of long-term priors on perception.
NATURE COMMUNICATIONS
(2021)
Article
Soil Science
Xiao Jun Allen Liu, Grace Pold, Luiz A. Domeignoz-Horta, Kevin M. Geyer, Hannah Caris, Hannah Nicolson, Kenneth M. Kemner, Serita D. Frey, Jerry M. Melillo, Kristen M. DeAngelis
Summary: The study found that long-term soil warming did not reduce the physical protection of soil organic matter, but it did have an impact on the carbon and nitrogen concentrations and extracellular enzyme activity in the soil. Long-term warming had little effect on soil microbial carbon use efficiency or microbial biomass turnover time, as it reduced both growth and respiration, but carbon use efficiency was less temperature sensitive in macroaggregates from the warmed plots.
SOIL BIOLOGY & BIOCHEMISTRY
(2021)
Article
Physics, Multidisciplinary
Nora Bachmann, Andreas Fitger, Lena Maria Maier, Andreas Mahlke, Olaf Schafer-Welsen, Thomas Koch, Kilian Bartholome
Summary: Elastocaloric cooling systems face challenges with long-term stability, but by applying compressive loads and utilizing heat transfer through evaporation and condensation of a fluid, enhanced long-term stability and cooling power density can be achieved.
COMMUNICATIONS PHYSICS
(2021)
Editorial Material
Multidisciplinary Sciences
Emma Nolan, Ilaria Malanchi
Article
Biochemical Research Methods
Luigi Ombrato, Emma Nolan, Diana Passaro, Ivana Kurelac, Victoria L. Bridgeman, Alexander Waclawiczek, Delfim Duarte, Cristina Lo Celso, Dominique Bonnet, Ilaria Malanchi
Summary: Understanding cell-cell interactions is crucial in biology research, and Cherry-niche is a powerful method that enables researchers to study intercellular crosstalk in vivo by labeling surrounding cells of interest. This technique has been successfully applied in cancer research to study the tumor microenvironment, with the potential to identify novel components and improve understanding of local interactions.
Article
Cell Biology
Diana Passaro, Manuel Garcia-Albornoz, Giovanni Diana, Probir Chakravarty, Linda Ariza-McNaughton, Antoniana Batsivari, Clara Borras-Eroles, Ander Abarrategi, Alexander Waclawiczek, Luigi Ombrato, Ilaria Malanchi, John Gribben, Dominique Bonnet
Summary: This study analyzed the role of the bone marrow niche in the development of acute myeloid leukemia using multi-omics and computational tools. It identified interactions between different stromal components and early deregulated genes during disease progression. Additionally, it predicted signaling nodes involved in niche alteration in AML by integrating BM proteomic secretome with transcriptome data.
Review
Immunology
Stefanie K. Wculek, Gillian Dunphy, Ignacio Heras-Murillo, Annalaura Mastrangelo, David Sancho
Summary: Cellular metabolism plays a crucial role in maintaining and regulating immune cell activities, with macrophages being essential for tissue homeostasis and potentially contributing to pathological conditions. Different macrophage populations in various organs have distinct functions, posing metabolic challenges for them to fulfill their roles in specific microenvironments.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Amelia Acha-Sagredo, Ilaria Malanchi, Francesca D. Ciccarelli
Summary: As individuals age, clones with somatic mutations in cancer driver genes become more prevalent in adult tissues, but the actual transformation into cancer is rare. Recent research suggests that competition between mutated clones with varying fitness levels may serve as a protective mechanism against tumor formation.
DEVELOPMENTAL CELL
(2021)
Review
Immunology
Daniela F. Quail, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andres Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Irina A. Udalova, Timo K. van den Berg, Denisa D. Wagner, Ping Wang, Arturo Zychlinsky, Karin E. de Visser, Mikala Egeblad, Paul Kubes
Summary: This article discusses the functional states and heterogeneity of neutrophils in cancer and provides a consensus statement on the controversies and solutions in neutrophil research. Further research is needed to understand the role of neutrophils in cancer and explore potential novel opportunities for cancer treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Immunology
Emma Nolan, Ilaria Malanchi
Summary: Research on neutrophils has expanded rapidly in recent decades, with a focus on their multifaceted functions in immunity, cancer, and tissue repair. Neutrophils are not only involved in tissue defense and repair, but also play key roles in cancer development.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Felipe S. Rodrigues, Francesca D. Ciccarelli, Ilaria Malanchi
Summary: The activation of developmental programmes by mutant cells is a fundamental requirement for cancer initiation. Oncogenic signals confer undifferentiated, stem cell-like properties to cancer cells, supporting their long-term proliferative potential. While mutations in cancer-driver genes alone are insufficient for tumor formation, the proliferation of cells with oncogenic mutations depends on their microenvironment. This Opinion article discusses how the reprogrammed status of cancer cells represents their tumorigenicity and triggers 'reflected stemness' in surrounding normal cells, contributing to the establishment of the tumor microenvironment (TME).
TRENDS IN CELL BIOLOGY
(2022)
Article
Oncology
Anna Perdrix Rosell, Oscar Maiques, Joshua Alexander James Martin, Probir Chakravarty, Luigi Ombrato, Victoria Sanz-Moreno, Ilaria Malanchi
Summary: The functional connection between cancer cells and their surrounding TME plays a crucial role in cancer development. Experimental evidence shows that perturbing the secretory profile of aggressive breast cancer cells can alter the tumor microenvironment, leading to the infiltration of anti-tumor macrophages and affecting long-term tumor growth.
Article
Oncology
Alvaro Teijeira, Saray Garasa, Carlos Luri-Rey, Carlos de Andrea, Maria Gato, Carmen Molina, Tsuneyasu Kaisho, Assunta Cirella, Arantza Azpilikueta, Steffanie K. Wculek, Josune Egea, Irene Olivera, Inmaculada Rodriguez, Ana Rouzaut, Vladislav Verkusha, Karmele Valencia, David Sancho, Pedro Berraondo, Ignacio Melero
Summary: The study highlights the critical role of cDC1 dendritic cells in influencing the efficacy of immunotherapy regimens, with depletion of these cells impacting antitumor immune responses. Results show that the presence of functional cDC1 cells at the initiation of immunotherapy is crucial for successful treatment of established tumors.
Article
Oncology
Emma Nolan, Victoria Louise Bridgeman, Luigi Ombrato, Adam Karoutas, Nicolas Rabas, Celine Angeli Natascha Sewneth, Marcos Vasquez, Felipe Silva Rodrigues, Stuart Horswell, Peter Faull, Rebecca Carter, Ilaria Malanchi
Summary: The study demonstrates a pro-tumorigenic activity of neutrophils in the context of radiotherapy. Activated neutrophils enhance tumor cell growth in the lung by promoting regenerative Notch signaling. Additionally, radiation exposure enhances the stemness phenotype of arriving cancer cells. Blocking neutrophil-dependent Notch activation significantly offsets radiation-enhanced metastases.
Review
Immunology
Catherine C. Hedrick, Ilaria Malanchi
Summary: Neutrophils have emerged as important regulators of cancer, revealing their diverse and plastic contributions in tumor development and growth, influencing positively and negatively depending on time, place, and disease context. Their functional importance in cancer has been overlooked due to their short-lived, terminally differentiated, and non-proliferative characteristics, but recent studies have led to a paradigm shift in understanding their roles.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Oncology
Luis Augusto Aguirre, Karla Montalban-Hernandez, Jose Avendano-Ortiz, Elvira Marin, Roberto Lozano, Victor Toledano, Laura Sanchez-Maroto, Veronica Terron, Jaime Valentin, Elisa Pulido, Jose Carlos Casalvilla, Carolina Rubio, Luke Diekhorst, Fernando Laso-Garcia, Carlos del Fresno, Ana Collazo-Lorduy, Beatriz Jimenez-Munarriz, Paloma Gomez-Campelo, Emilio Llanos-Gonzalez, Maria Fernandez-Velasco, Carlos Rodriguez-Antolin, Rebeca Perez de Diego, Ramon Cantero-Cid, Enrique Hernadez-Jimenez, Enrique Alvarez, Rocio Rosas, Blanca Dies Lopez-Ayllon, Javier de Castro, Stefanie K. Wculek, Carolina Cubillos-Zapata, Inmaculada Ibanez de Caceres, Prudencio Diaz-Agero, Maria Gutierrez Fernandez, Maria Paz de Miguel, David Sancho, Leon Schulte, Rosario Perona, Cristobal Belda-Iniesta, Lisardo Bosca, Eduardo Lopez-Collazo
Review
Immunology
Stefanie K. Wculek, Francisco J. Cueto, Adriana M. Mujal, Ignacio Melero, Matthew F. Krummel, David Sancho
NATURE REVIEWS IMMUNOLOGY
(2020)