Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

Continuous monitoring of neutrophils to lymphocytes ratio for estimating the onset, severity, and subsequent prognosis of immune related adverse events

(2021) Ryosuke Matsukane et al.   Scientific Reports

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

(2021) Sijin Cheng et al.   CELL

Chemotherapy-associated steatohepatitis

(2020) Lucy Meunier et al.   Annals of Hepatology

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity

(2020) Alexander H. Morrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Durable and controlled depletion of neutrophils in mice

(2020) Gael Boivin et al.   Nature Communications

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity

(2020) Caroline Bonnans et al.   Journal for ImmunoTherapy of Cancer

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

(2020) Adrienne M. Luoma et al.   CELL

Line-selective macrophage activation with an anti-CD40 antibody drives a hemophagocytic syndrome in mice

(2020) Giada Ingoglia et al.   Blood Advances

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

(2020) Catherine S. Grasso et al.   CANCER CELL

Tumor-infiltrating dendritic cell states are conserved across solid human cancers

(2020) Genevieve M. Gerhard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

(2019) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

(2019) E. Antonio Chiocca et al.   Science Translational Medicine

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Immune Checkpoint Inhibitor Therapy in Patients With Preexisting Inflammatory Bowel Disease

(2019) Hamzah Abu-Sbeih et al.   JOURNAL OF CLINICAL ONCOLOGY

Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses

(2019) Samantha K. Greaney et al.   Cancer Immunology Research

Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2018) J B A G Haanen et al.   ANNALS OF ONCOLOGY

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adverse Events Associated with Immune Checkpoint Blockade

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Association of Immune-Related Adverse Events With Nivolumab Efficacy in Non–Small-Cell Lung Cancer

(2018) Koji Haratani et al.   JAMA Oncology

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Identification of pro-inflammatory CD205+ macrophages in livers of hepatitis B virus transgenic mice and patients with chronic hepatitis B

(2017) Liang Yong et al.   Scientific Reports

CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells

(2016) Xin Hou et al.   Cellular & Molecular Immunology

CSF-1R–Dependent Lethal Hepatotoxicity When Agonistic CD40 Antibody Is Given before but Not after Chemotherapy

(2016) Katelyn T. Byrne et al.   JOURNAL OF IMMUNOLOGY

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Single-cell barcoding and sequencing using droplet microfluidics

(2016) Rapolas Zilionis et al.   Nature Protocols

Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1 STEM Mouse

(2016) Francois E. Mercier et al.   Stem Cell Reports

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study

(2015) P. Johnson et al.   CLINICAL CANCER RESEARCH

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Interleukin 12: still a promising candidate for tumor immunotherapy?

(2014) Witold Lasek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

(2013) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events

(2013) Vafa Shahabi et al.   Journal of Translational Medicine

Qualimap: evaluating next-generation sequencing alignment data

(2012) Fernando García-Alcalde et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Ly6G ligation blocks recruitment of neutrophils via a  2-integrin-dependent mechanism

(2012) J.-X. Wang et al.   BLOOD

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

(2012) Matthew M. Meredith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of hepatocyte fate by interferon-γ

(2011) Christopher J. Horras et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Specific depletion reveals a novel role for neutrophil-mediated protection in the liver during Listeria monocytogenes infection

(2011) Karen D. Carr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE