Article
Biology
Xing Li, Jie Chen, Yong-Jian Chen, Yi-Dan Qiao, Li-Yun Zhao, Nan Jiang, Xiang-Yuan Wu, Yan-Fang Xing
Summary: Li et al. demonstrate that dexamethasone and lactoferrin induced polymorphonuclear myeloid-derived suppressor cells relieve inflammatory conditions in mouse models with minimal effect on tumour growth, showing promise for combating inflammatory adverse events during anti-cancer treatments.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Yingying Sun, Yan Mo, Shu Jiang, Chao Shang, Yunpeng Feng, Xianlu Zeng
Summary: CXCL10 is significantly upregulated in melanoma mice and promotes the proliferation of MDSCs, leading to the abnormal accumulation of mo-MDSCs under tumor conditions. This finding provides a new understanding of the mechanism underlying the formation of a tumor-induced immunosuppressive microenvironment and suggests CXCL10 as a potential target for slowing tumor progression.
Article
Cell Biology
Xiaoqing Li, Yixue Li, Qinru Yu, Lin Xu, Shan Fu, Cong Wei, Limengmeng Wang, Yi Luo, Jimin Shi, Pengxu Qian, He Huang, Yu Lin
Summary: mTOR signaling regulates MDSCs' generation via the STAT3-C/EBP beta pathway. Infusion of mTOR(KO) PMN-MDSCs shows potential in preventing and treating aGVHD by alleviating cytokine storm and promoting the recovery of PMN-MDSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Haiyan Wang, Xuehui Li, Guanjun Dong, Fenglian Yan, Junfeng Zhang, Hui Shi, Zhaochen Ning, Min Gao, Dalei Cheng, Qun Ma, Changying Wang, Mingsheng Zhao, Jun Dai, Chunxia Li, Zhihua Li, Hui Zhang, Huabao Xiong
Summary: The study revealed that TAK-242 has a protective effect against explosive hepatitis by regulating MDSCs, suppressing inflammation, reducing oxidative stress, and increasing the proportion of MDSCs.
Article
Clinical Neurology
Benjamin T. Himes, Cori E. Fain, Zachariah P. Tritz, Cody L. Nesvick, Helen J. Jin-Lee, Philipp A. Geiger, Timothy E. Peterson, Mi-Yeon Jung, Ian F. Parney
Summary: This study investigates the immunosuppressive effects in glioblastoma (GBM) patients and finds that GBM-derived extracellular vesicles (EVs) can induce the formation of immunosuppressive monocytes. The researchers show that heparin can disrupt the interaction between GBM EVs and monocytes, thereby mitigating immune suppression. Additionally, they demonstrate that inhibiting MDSC formation with heparin partially rescues immune suppression.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Yael Delgado-Ramirez, Itzel Baltazar-Perez, Yamileth Martinez, Blanca E. Callejas, Itzel Medina-Andrade, Jonadab E. Olguin, Norma L. Delgado-Buenrostro, Yolanda Chirino, Luis Terrazas, Sonia Leon-Cabrera
Summary: The study demonstrates that the lack of STAT1 leads to increased tumorigenicity in colitis-associated colorectal cancer and this can be suppressed by neutralizing IL-17. The findings suggest that targeting IL-17 could potentially prevent tumor formation associated with STAT1 deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Yan Lu, Yi Xiao, Ming-Zhu Yin, Xing-Chen Zhou, Li-Sha Wu, Wang-Qing Chen, Yan Luo, Ye-Hong Kuang, Wu Zhu
Summary: The study found that PEG ointment improves IMQ-induced psoriasis-like inflammation by reducing the function of Th17 cells and MDSCs, alleviating the appearance of lesions and epidermal proliferation in psoriasis mice.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Zhiqian Zhang, Xu Huang, Enlin Wang, Yugang Huang, Rongcun Yang
Summary: The study revealed that two subsets of murine Gr1(+)CD11b(+) cells, B220(+) and B220(-), have differing effects on tumor metastasis and cancer cell motility. IL-6 signaling pathway plays opposing roles in the expansion of B220(-) MDSCs and B220(+) counterparts, indicating potential therapeutic implications for inducing MDSCs to B220(+) cells in cancer therapy.
Article
Virology
Yong Tan, Shuaiyao Lu, Bo Wang, Xuewen Duan, Yunkai Zhang, Xiaozhong Peng, Hangwen Li, Ang Lin, Zhenzhen Zhan, Xingguang Liu
Summary: The SW0123 mRNA vaccine protects against lung damage caused by SARS-CoV-2 infection by suppressing inflammatory responses, increasing the frequency of polymorphonuclear myeloid-derived suppressor cells, and inhibiting apoptosis in lung epithelial and endothelial cells.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Andrea Duminuco, Uros Markovic, Nunziatina Laura Parrinello, Luca Lo Nigro, Elisa Mauro, Calogero Vetro, Marina Parisi, Cinzia Maugeri, Paolo Fabio Fiumara, Giuseppe Milone, Alessandra Romano, Francesco Di Raimondo, Salvatore Leotta
Summary: Blinatumomab, a bispecific anti-CD3 and anti-CD19 antibody, shows potential in treating B-cell precursor acute lymphoblastic leukemia (Bcp-ALL). Preliminary results suggest that patients with higher baseline T-lymphocyte proportion achieve better molecular response. Further studies are needed to evaluate T-cell kinetics and potential synergy effects in targeting myeloid-derived suppressor cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hazel Quek, Carla Cuni-Lopez, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Tam Hong Nguyen, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Tara L. Roberts, Yi Chieh Lim, Lotta E. Oikari, Vincenzo La Bella, Anthony R. White
Summary: Researchers successfully recapitulated the pathological features of ALS using monocyte-derived microglia-like cells, and found significant cellular functional differences in ALS patients with different disease progression rates. These findings help to reveal patient heterogeneity in ALS and provide a basis for personalized treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Haitao Gu, Wensheng Deng, Zhong Zheng, Ke Wu, Feng Sun
Summary: The study indicates that PDAC cells produce CCL2, which promotes localized recruitment of M-MDSCs and immune suppression, thereby promoting tumor progression.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Medicine, Research & Experimental
Fengqi Li, Katarzyna Maria Okreglicka, Federica Piattini, Lea Maria Pohlmeier, Christoph Schneider, Manfred Kopf
Summary: This study demonstrates a method to rapidly differentiate fetal liver monocytes into alveolar macrophage-like population using GM-CSF. These cells, named CSF2-cFLiMo, retain the capacity to develop into functional alveolar macrophages, preventing the development of alveolar proteinosis and accumulation of apoptotic cells. Compared with macrophages derived from bone marrow cells, CSF2-cFLiMo more efficiently engraft empty alveolar macrophage niches and protect mice from severe pathology induced by respiratory viral infection.
Article
Chemistry, Analytical
Takashi Ozaki, Norikazu Ohta, Motohiro Fujiyoshi
Summary: Laser scanners with mechanically driven mirrors have the potential for various applications. Non-resonant scanners are necessary for point-to-point driving applications. This paper presents a two-axis scanner with a piezoelectric actuator, achieving high linearity and large deflection angles.
Article
Chemistry, Multidisciplinary
Hui Li
Summary: In this study, ammonium oxofluorotitanates were synthesized through the in situ hydrolysis of (NH4)2TiF6 produced in the field-assisted dissolution of fresh TiO2 during the high-field anodization of titanium. The obtained products can be converted to mesocrystalline anatase TiO2 upon thermal annealing.
Article
Multidisciplinary Sciences
Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W. Goodrich, Peter McCue, Andrew Kossenkov, Amy C. Mandigo, Karen E. Knudsen, Paul H. Weinreb, Eva Corey, William K. Kelly, Lucia R. Languino
Summary: The study demonstrates an upregulation of the α V β3 integrin in NEPrCa primary and metastatic lesions, while the α V β6 integrin is confined to prostate adenocarcinoma. The findings suggest that α V β3 integrin may promote a shift in lineage plasticity towards a NE phenotype and serve as a biomarker for early detection of NE differentiation in prostate cancer.
Article
Multidisciplinary Sciences
Marco Trizzino, Avery Zucco, Sandra Deliard, Fang Wang, Elisa Barbieri, Filippo Veglia, Dmitry Gabrilovich, Alessandro Gardini
Summary: Analyzing the EGR1 transcription factor can reveal the molecular determinants of monocytic and macrophagic commitment, with EGR1 being essential for monopoiesis but showing a different binding pattern in differentiating macrophages. The repressive activity of EGR1 on inflammatory genes is mediated by the NuRD corepressor complex, even in the absence of its binding motif.
Review
Cell Biology
Alessandra De Leo, Alessio Ugolini, Filippo Veglia
Summary: Glioblastoma (GBM) is a highly aggressive and malignant brain tumor with a unique immune microenvironment that is resistant to immunotherapy. Myeloid cells play a crucial role in regulating immune and therapeutic responses in GBM. Studying the characteristics and functions of different populations of myeloid cells in GBM offers new insights for targeting specific cells for therapeutic purposes.
Article
Immunology
Filippo Veglia, Ayumi Hashimoto, Harsh Dweep, Emilio Sanseviero, Alessandra De Leo, Evgenii Tcyganov, Andrew Kossenkov, Charles Mulligan, Brian Nam, Gregory Masters, Jaymala Patel, Vipul Bhargava, Patrick Wilkinson, Denis Smirnov, Manuel A. Sepulveda, Sunil Singhal, Evgeniy B. Eruslanov, Razvan Cristescu, Andrey Loboda, Yulia Nefedova, Dmitry I. Gabrilovich
Summary: In this study, the heterogeneity of polymorphonuclear neutrophils (PMNs) in cancer was characterized using various methods, revealing different populations of PMNs. Evidence was provided to show that PMN-MDSCs are a distinct population of PMNs with unique features and potential for selective targeting opportunities.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Virology
Fang Lu, Kayla A. Martin, Samantha S. Soldan, Andrew Kossenkov, Priyankara Wickramasinghe, Olga Vladimirova, Alessandra De Leo, Cindy Lin, Yulia Nefedova, Paul M. Lieberman
Summary: Aberrant viral genomes and lytic gene expression are found in rare B cells derived from multiple myeloma tumors, suggesting a potential role of Epstein-Barr virus (EBV) in the etiology of multiple myeloma. Further studies are needed to fully understand the mechanisms of EBV oncogenesis in this context.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Kevin Alicea-Torres, Emilio Sanseviero, Jun Gui, Jinyun Chen, Filippo Veglia, Qiujin Yu, Laxminarasimha Donthireddy, Andrew Kossenkov, Cindy Lin, Shuyu Fu, Charles Mulligan, Brian Nam, Gregory Masters, Fred Denstman, Joseph Bennett, Neil Hockstein, Agnieszka Rynda-Apple, Yulia Nefedova, Serge Y. Fuchs, Dmitry Gabrilovich
Summary: Type I interferon receptor signaling serves as a universal mechanism restricting MDSC suppressive activity, with downregulation of IFNAR1 required for activation of immune suppressive properties in MDSC. Modulating IFNAR1 undermines MDSC suppressive activity and has potent anti-tumor effects.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Ekta Agarwal, Aaron R. Goldman, Hsin-Yao Tang, Andrew V. Kossenkov, Jagadish C. Ghosh, Lucia R. Languino, Valentina Vaira, David W. Speicher, Dario C. Altieri
Summary: Parkin, an E3 ubiquitin ligase altered in Parkinson's disease, is shown to suppress tumor growth by shutting off mitochondrial dynamics and inhibiting the non-oxidative phase of the pentose phosphate pathway. This tumor suppression function of Parkin requires its E3 ligase activity and can be reversed by antioxidants, independently of mitophagy. Cancer metabolic networks are identified as potential oncogenes directly targeted by endogenous tumor suppression mechanisms.
Article
Biochemistry & Molecular Biology
Nicole M. Naranjo, Israa Salem, Maisha A. Harris, Lucia R. Languino
Summary: The reduction of the avi36 integrin subunit increases the expression of IFIT3 in prostate cancer cells and their derived sEVs. Cells lacking the i36 integrin subunit show high expression of IFIT3 and STAT1, with IFIT3 present in sEVs but not STAT1. Loss of IFIT3 leads to enriched STAT1 in sEVs as a compensatory mechanism.
BIOCHEMICAL JOURNAL
(2021)
Article
Oncology
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino
Summary: The alpha V beta 6 integrin is upregulated during prostate cancer progression and specifically expressed in androgen receptor-negative tumors. By delivering ITGB6-targeting siRNAs into PrCa cells using sEVs, the expression of beta 6 subunit can be downregulated, leading to reduced cell adhesion and migration in PrCa cells.
CANCER BIOLOGY & THERAPY
(2022)
Article
Multidisciplinary Sciences
Jagadish C. Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R. Goldman, Hsin-Yao Tang, Andrew Kossenkov, Catherine J. Libby, Lucia R. Languino, Edward F. Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W. Speicher, M. Cecilia Caino, Joel Cassel, Joseph M. Salvino, Marie E. Robert, Valentina Vaira, Dario C. Altieri
Summary: The study reveals that many human tumors have reduced levels of Mic60, an essential scaffold of mitochondrial structure, which leads to the disruption of mitochondrial integrity. Surprisingly, these tumors show decreased cell proliferation, resistance to cell death, and activation of a gene expression program related to innate immunity and cytokine/chemokine signaling. This process induces epithelial-mesenchymal transition, tumor cell movement, and promotes metastatic dissemination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Michael Xu, Latese Evans, Candice L. Bizzaro, Fabio Quaglia, Cecilia E. Verrillo, Li Li, Julia Stieglmaier, Matthew J. Schiewer, Lucia R. Languino, William K. Kelly
Summary: Despite therapeutic advances in prostate cancer treatment, metastatic castration-resistant prostate cancer remains a challenge. Highly expressed proteins STEAP1-4 have been identified as significant drivers of prostate cancer aggressiveness and metastasis. However, their other biological functions and understanding of heterotrimers and homotrimers are limited. This review highlights the importance of further research on the role of STEAP1-4 in prostate cancer and their potential clinical applications.
Article
Multidisciplinary Sciences
Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter McCue, Andrew Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, Lucia R. Languino
Summary: This study reveals a novel pathway activated by αVβ3 that promotes NEPrCa differentiation. NgR2 associates with αVβ3 and promotes NED and anchorage-independent growth in PrCa cells. These findings provide important insights into the mechanistic understanding of PrCa progression towards a NE phenotype.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Filippo Veglia, Emilio Sanseviero, Dmitry I. Gabrilovich
Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.
NATURE REVIEWS IMMUNOLOGY
(2021)