MDSC: Markers, development, states, and unaddressed complexity

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

(2020) Zhihao Lu et al.   NATURE

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

(2020) Ashley M. Laughney et al.   NATURE MEDICINE

Lineage tracing on transcriptional landscapes links state to fate during differentiation

(2020) Caleb Weinreb et al.   SCIENCE

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

(2020) Hamad Alshetaiwi et al.   Science Immunology

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

(2020) Sarah Bowling et al.   CELL

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

(2020) Eslam Mohamed et al.   IMMUNITY

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Mouse models of neutropenia reveal progenitor-stage-specific defects

(2020) David E. Muench et al.   NATURE

Common germline variants of the human APOE gene modulate melanoma progression and survival

(2020) Benjamin N. Ostendorf et al.   NATURE MEDICINE

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

(2020) Yonatan Katzenelenbogen et al.   CELL

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

(2020) Martina Molgora et al.   CELL

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

(2020) Immanuel Kwok et al.   IMMUNITY

Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations

(2020) Patricia J. Ahl et al.   Communications Biology

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

(2019) Leif S. Ludwig et al.   CELL

Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates

(2019) Luca Cassetta et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells

(2019) Eleni P. Mimitou et al.   NATURE METHODS

Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation

(2019) Denise E. de Almeida Nagata et al.   Cell Reports

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

(2019) Jin Xu et al.   eLife

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs

(2019) Jérôme Mastio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes

(2019) Wurood Hantoosh Neamah et al.   JOURNAL OF IMMUNOLOGY

Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue

(2019) Yu Si et al.   Science Immunology

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

(2019) Marie Jo Halaby et al.   Science Immunology

Clonal analysis of lineage fate in native haematopoiesis

(2018) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

(2018) Sachin Pundhir et al.   Cell Reports

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

(2018) Takanori Kitamura et al.   Frontiers in Immunology

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases

(2018) Luana de Mendonça Oliveira et al.   MEDIATORS OF INFLAMMATION

Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells

(2018) Lintao Zhao et al.   NATURE MEDICINE

Developmental barcoding of whole mouse via homing CRISPR

(2018) Reza Kalhor et al.   SCIENCE

T-cell–Secreted TNFα Induces Emergency Myelopoiesis and Myeloid-Derived Suppressor Cell Differentiation in Cancer

(2018) Mohamad F. Al Sayed et al.   CANCER RESEARCH

Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

(2018) Aleksandra Wroblewska et al.   CELL

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

(2018) Marion Orsini et al.   CELL DEATH AND DIFFERENTIATION

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

(2018) Vincent Bernard et al.   CLINICAL CANCER RESEARCH

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

(2018) Benjamin Knier et al.   NATURE IMMUNOLOGY

Neutrophils in Homeostasis, Immunity, and Cancer

(2017) José Ángel Nicolás-Ávila et al.   IMMUNITY

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

(2017) Alberto Yáñez et al.   IMMUNITY

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

(2017) Wen Pan et al.   IMMUNITY

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production

(2017) Colleen S. Netherby et al.   JOURNAL OF IMMUNOLOGY

Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow

(2017) Mikael Roussel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages

(2017) Derek R. Clements et al.   JOURNAL OF PROTEOME RESEARCH

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

(2017) Aurélie Hérault et al.   NATURE

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

(2017) Weike Pei et al.   NATURE

Mapping the human DC lineage through the integration of high-dimensional techniques

(2017) Peter See et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Regulation of Inflammation- and Infection-Driven Hematopoiesis

(2017) Steffen Boettcher et al.   TRENDS IN IMMUNOLOGY

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

(2017) Jingjing Zhu et al.   Nature Communications

Dual negative roles of C/EBPα in the expansion and pro-tumor functions of MDSCs

(2017) John R. Mackert et al.   Scientific Reports

Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2

(2017) Justine Newson et al.   Cell Reports

Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells

(2017) Javier Rodríguez-Ubreva et al.   Cell Reports

All-Trans Retinoic Acid Prevents Osteosarcoma Metastasis by Inhibiting M2 Polarization of Tumor-Associated Macrophages

(2017) Qian Zhou et al.   Cancer Immunology Research

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells

(2017) Branko Cirovic et al.   Stem Cell Reports

IFN-γ–STAT1–iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity

(2017) Shu-Han Yang et al.   Frontiers in Immunology

Issues with anti-Gr1 antibody-mediated myeloid-derived suppressor cell depletion

(2016) Yan-Fang Xing et al.   ANNALS OF THE RHEUMATIC DISEASES

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

(2016) Diego Adhemar Jaitin et al.   CELL

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients

(2016) Kilian Wistuba-Hamprecht et al.   JOURNAL OF IMMUNOLOGY

Editorial: “Invisible” MDSC in tumor-bearing individuals after antibody depletion: fact or fiction?

(2016) Chi Ma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of an atypical monocyte and committed progenitor involved in fibrosis

(2016) Takashi Satoh et al.   NATURE

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

Identification of early myeloid progenitors as immunosuppressive cells

(2016) Shiming Pu et al.   Scientific Reports

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production

(2015) A. Yanez et al.   BLOOD

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

(2015) Amber Jin Giles et al.   CANCER RESEARCH

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity

(2014) Ingunn M Stromnes et al.   GUT

The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

(2014) Paul T. Thevenot et al.   IMMUNITY

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

“Of Mice and Men”: Arginine Metabolism in Macrophages

(2014) Anita C. Thomas et al.   Frontiers in Immunology

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

(2013) Janesh Pillay et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+T-cell activation events

(2013) Elio Schouppe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancer

(2013) Robert Wesolowski et al.   Journal for ImmunoTherapy of Cancer

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

(2012) Thibault Griseri et al.   IMMUNITY

S100A9 a new marker for monocytic human myeloid-derived suppressor cells

(2012) Fei Zhao et al.   IMMUNOLOGY

Zbtb46expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

(2012) Ansuman T. Satpathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

(2012) Matthew M. Meredith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

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(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Myeloid-derived suppressor cell activation by combined LPS and IFN-γ treatment impairs DC development

(2009) Verena Greifenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics

(2008) Naoki Umemura et al.   JOURNAL OF LEUKOCYTE BIOLOGY