The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer

(2017) Siker Kimbung et al.   ENDOCRINE-RELATED CANCER

Cholesterol, Cholesterol-Lowering Medication Use, and Breast Cancer Outcome in the BIG 1-98 Study

(2017) Signe Borgquist et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study

(2017) Florence Dalenc et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects

(2016) Wei Wei et al.   Cell Metabolism

Tumor Cell–Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells

(2016) Nikolaos Svoronos et al.   Cancer Discovery

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis

(2014) D. P. McDonnell et al.   CANCER RESEARCH

The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha

(2014) Michihisa Umetani et al.   Cell Metabolism

Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression

(2014) Regina Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol and Cancer, in the Balance

(2014) S. Silvente-Poirot et al.   SCIENCE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Cholesterol and breast cancer pathophysiology

(2014) Erik R. Nelson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients

(2013) S. Jiralerspong et al.   ANNALS OF ONCOLOGY

5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells

(2013) Gregory Segala et al.   BIOCHEMICAL PHARMACOLOGY

Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial

(2013) Olöf Bjarnadottir et al.   BREAST CANCER RESEARCH AND TREATMENT

Transcription factor ATF3 links host adaptive response to breast cancer metastasis

(2013) Chris C. Wolford et al.   JOURNAL OF CLINICAL INVESTIGATION

The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

(2013) Laura Raccosta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

(2013) Philippe de Medina et al.   Nature Communications

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

Statin use and risk of breast cancer: a meta-analysis of observational studies

(2012) Krishna Undela et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

(2012) Thomas Jamieson et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Infiltrating    T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

(2012) C. Ma et al.   JOURNAL OF IMMUNOLOGY

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

(2012) N Alikhani et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Role of Cholesterol in the Development and Progression of Breast Cancer

(2011) Gemma Llaverias et al.   AMERICAN JOURNAL OF PATHOLOGY

The Oxysterol, 27-Hydroxycholesterol, Links Cholesterol Metabolism to Bone Homeostasis Through Its Actions on the Estrogen and Liver X Receptors

(2011) Erik R. Nelson et al.   ENDOCRINOLOGY

Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study

(2011) T. P. Ahern et al.   JNCI-Journal of the National Cancer Institute

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism

(2010) Ratna Karuna et al.   ATHEROSCLEROSIS

The Endogenous Selective Estrogen Receptor Modulator 27-Hydroxycholesterol Is a Negative Regulator of Bone Homeostasis

(2010) Carolyn D. DuSell et al.   ENDOCRINOLOGY

Efficient Killing of Human Colon Cancer Stem Cells by    T Lymphocytes

(2009) M. Todaro et al.   JOURNAL OF IMMUNOLOGY

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator

(2007) Carolyn D. DuSell et al.   MOLECULAR ENDOCRINOLOGY