Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

(2020) Linbin Yang et al.   NATURE

Cancer cell–induced neutrophil extracellular traps promote both hypercoagulability and cancer progression

(2019) Hye Soo Jung et al.   PLoS One

Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis

(2019) Xueqian Zhuang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

(2019) Ik Sun Kim et al.   NATURE CELL BIOLOGY

DNA Area and NETosis Analysis (DANA): a High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images

(2018) Ryan Rebernick et al.   BIOLOGICAL PROCEDURES ONLINE

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

(2018) Robert Palmér et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

(2018) Brice Korkmaz et al.   PHARMACOLOGY & THERAPEUTICS

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

(2018) WonJae Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1

(2017) Xueqian Zhuang et al.   NATURE CELL BIOLOGY

A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity

(2017) Jing Hu et al.   Cell Death & Disease

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

(2017) Vidal Delgado-Rizo et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

(2016) Yveline Hamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model

(2016) Bethany M. Biron et al.   Journal of Innate Immunity

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

(2016) Kevin Doyle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

Lysyl Oxidase Contributes to Mechanotransduction-Mediated Regulation of Transforming Growth Factor-β Signaling in Breast Cancer Cells

(2015) Molly A. Taylor et al.   NEOPLASIA

Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D

(2014) Rachel E. Sutherland et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isolation of plasma membrane–associated membranes from rat liver

(2014) Jan M Suski et al.   Nature Protocols

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

(2013) B. Ruffell et al.   GENES & DEVELOPMENT

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

The secretion of IL-1β and options for release

(2013) Patrizia Piccioli et al.   SEMINARS IN IMMUNOLOGY

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)

(2013) Brice Korkmaz et al.   Seminars in Immunopathology

Bone Marrow–Derived Gr1 + Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1

(2013) Raúl Catena et al.   Cancer Discovery

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors

(2012) Peter Sjö   Future Medicinal Chemistry

Neutrophil Serine Proteases Promote IL-1  Generation and Injury in Necrotizing Crescentic Glomerulonephritis

(2012) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

IL-6 plays an essential role in neutrophilia under inflammation

(2011) Misato Hashizume et al.   CYTOKINE

Molecular analysis of the membrane insertion domain of proteinase 3, the Wegenerˈs autoantigen, in RBL cells: implication for its pathogenic activity

(2011) Chahrazade Kantari et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function

(2010) Christopher E Andoniou et al.   IMMUNOLOGY AND CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Catalytic Activity and Inhibition of Wegener Antigen Proteinase 3 on the Cell Surface of Human Polymorphonuclear Neutrophils

(2009) Brice Korkmaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates

(2008) Brice Korkmaz et al.   Nature Protocols