Review
Biochemistry & Molecular Biology
Khetam Sounbuli, Nadezhda Mironova, Ludmila Alekseeva
Summary: Neutrophils, the most abundant leukocytes in human blood, have been recognized as important players in the innate immune system and the first line of defense against invading pathogens. Recent studies have revealed their active involvement in the immune response during cancer development. They exhibit both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Furthermore, the existence of different subpopulations of neutrophils challenges the traditional concept of their homogeneity and opens new possibilities for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Man Yan, Minying Zheng, Rui Niu, Xiaohui Yang, Shifeng Tian, Linlin Fan, Yuwei Li, Shiwu Zhang
Summary: This review article describes the potential mechanisms of tumor-associated neutrophils (TANs) in tumor metastasis and the promising future of cancer immunotherapy through targeting TANs with chemotherapeutic drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zebin Yang, Yu Luo, Huizhu Yu, Kaicheng Liang, Miao Wang, Qigang Wang, Bo Yin, Hangrong Chen
Summary: This study has constructed a novel nanomaterial to reshape the immunosuppressive tumor microenvironment. The nanomaterial can generate reactive oxygen species to alleviate tumor hypoxia and promote the polarization of tumor-associated macrophages. The light-activated nanoplatform can activate and recruit immune cells in combination with radiotherapy, reversing the immunosuppressive tumor microenvironment and enhancing immune responses.
ADVANCED MATERIALS
(2022)
Review
Immunology
Junjie Zhao, Jiaqi Jin
Summary: This review discusses recent investigations into NETs and their roles in tumor biology, as well as explores their potential as therapeutic targets in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Charlotte R. Bell, Victoria S. Pelly, Agrin Moeini, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Christopher Clark, Charles H. Earnshaw, Maria A. Koufaki, Eduardo Bonavita, Santiago Zelenay
Summary: The release of PGE2 from dying cancer cells, mediated by COX-2, contributes to resistance against cytotoxic therapy. This study shows that cytotoxic drugs only induce PGE2 release in cancer cells with basal COX-2 activity, and that pharmacological COX-2 inhibition can enhance the efficacy of chemotherapy and PD-1 blockade combination. Additionally, all types of chemotherapy drugs enhance COX-2 transcription and inhibit cancer cell proliferation.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Haiying Que, Qianmei Fu, Tianxia Lan, Xiaohe Tian, Xiawei Wei
Summary: This review discusses the complex roles of neutrophils in the tumor microenvironment and highlights the progress in neutrophil-targeted therapies in ongoing clinical trials.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Immunology
Merav E. Shaul, Zvi G. Fridlender
Summary: Neutrophils play a dual role in cancer, supporting tumor growth while also inhibiting cancer development. They exhibit plasticity and diversity, allowing them to perform various and sometimes opposing functions simultaneously. The net impact of neutrophils in cancer is a complex balance between contradicting effects occurring simultaneously.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Immunology
Abhishek Dutta, Shrikrishna Bhagat, Swastika Paul, Jonathan P. Katz, Debomita Sengupta, Dharmendra Bhargava
Summary: Neutrophils, the most abundant immune cells in human blood, play a critical role in the innate immune response. However, in cancer, tumors can manipulate neutrophils to either promote or hinder tumor growth. These tumor-induced neutrophils can secrete exosomes that deliver various cargos, contributing to tumor growth and degradation of the extracellular matrix.
Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Hao Zhou, Xiaoyun He, Yuxiang He, Chunlin Ou, Pengfei Cao
Summary: Exosomes play crucial roles in a range of human diseases, especially malignant tumors, by transmitting cargo for intercellular communication. Exosomal circRNAs have the potential to regulate tumor cell metastasis and serve as valuable diagnostic biomarkers and therapeutic targets in cancer patients. The mechanism by which exosomal circRNAs modulate metastatic phenomena and the prospects of their clinical applications in tumor therapy are discussed in this review.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim
Summary: IL-32 plays a contradictory role in cancer development, with its high expression typically associated with tumor proliferation and progression. However, different isoforms of IL-32 may have different effects in cancer, such as IL-32 beta promoting cancer expansion and IL-32 theta inhibiting epithelial-mesenchymal transition. Further research is needed to understand the role of IL-32 in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Christiana M. Neophytou, Myrofora Panagi, Triantafyllos Stylianopoulos, Panagiotis Papageorgis
Summary: The tumor microenvironment (TME) plays a crucial role in cancer progression, influencing tumor aggressiveness, dissemination, and immune evasion. Interactions between cellular and structural TME components enable cancer cells to invade and spread, and the extracellular matrix (ECM) also affects cancer cell migration and therapy response. Current and future strategies aim to target these components to block metastasis.
Review
Biology
Justin K. Messex, Geou-Yarh Liou
Summary: Prostate cancer is the most common cancer in senior American men. Although the five-year survival rate after initial diagnosis is high, metastatic prostate cancer remains the second leading cause of cancer death in senior men. The tumor microenvironment, including immune cells, plays a crucial role in the development and progression of prostate cancer. This article summarizes the mechanisms by which infiltrating immune cells regulate prostate cancer metastasis and suggests potential strategies for treatment and prevention by targeting the tumor microenvironment.