Article
Multidisciplinary Sciences
Marlene Cervantes, Robert G. Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Corsi
Summary: The circadian clock and metabolism are closely linked, relying on interactions between organ systems for proper timing. Substance use disrupts communication between organs and alters rhythmic activities. This study finds that alterations in dopamine signaling in the brain can affect circadian metabolism in peripheral organs. Drugs like cocaine that increase dopamine levels disrupt circadian metabolic profiles in the liver, especially when dopamine D2 receptors are lost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Ning Qin, Shuijing Yi, Chanyuan Dai, Xiangyu Liu, Yinglong Duan, Yi Zhou, Ziyu Wan, Yue Kang, Xing Zhou, Jianfei Xie, Andy S. K. Cheng
Summary: There are associations between various features of serum cortisol and inflammatory markers and depression and anxiety in young women with gynecologic cancer.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Immunology
Krisztina Ella, Agnes R. Sudy, Zsofia Bur, Bence Koos, Armin S. Kisiczki, Attila Mocsai, Krisztina Kaldi
Summary: Time restricted eating can reduce the symptoms of autoinflammatory joint arthritis and modulate the rhythm and inflammatory potential of leukocytes, leading to a milder reactivity of the immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jan Kroon, Maaike Schilperoort, Wietse In Het Panhuis, Rosa van den Berg, Lotte van Doeselaar, Cristy R. C. Verzijl, Nikki van Trigt, Isabel M. Mol, Hetty H. C. M. Sips, Jose K. van den Heuvel, Lisa L. Koorneef, Ronald J. van der Sluis, Anna Fenzl, Florian W. Kiefer, Sabine Vettorazzi, Jan P. Tuckermann, Nienke R. Biermasz, Onno C. Meijer, Patrick C. N. Rensen, Sander Kooijman
Summary: This study demonstrates that the physiological rhythm of glucocorticoids plays a crucial role in regulating BAT function, and long-term flattening of corticosterone levels can lead to adiposity.
MOLECULAR METABOLISM
(2021)
Review
Allergy
Koichi Ikuta, Aki Ejima, Shinya Abe, Akihiro Shimba
Summary: Steroid hormones, especially glucocorticoids, androgens, and estrogens, have significant effects on the immune system, with glucocorticoids exhibiting anti-inflammatory and immunosuppressive effects while also enhancing adaptive immunity, and androgens alleviating allergic airway inflammation through the suppression of cell activation and differentiation.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Joseph R. Knoedler, Cristina Saenz de Miera, Arasakumar Subramani, Robert J. Denver
Summary: The gene KLF9 plays an important role in the liver's response to stress-induced Per1 mRNA, while the potential role of B in this response needs further investigation.
Article
Biochemistry & Molecular Biology
Paul Kwangho Kwon, Hyo-Min Kim, Byunghee Kang, Sung Wook Kim, Sung-Min Hwang, Sin-Hyeog Im, Tae-Young Roh, Kyong-Tai Kim
Summary: This study demonstrates that hnRNP K activates the transcription of ROR gamma through the poly(C) motif within its proximal promoter, affecting the circadian rhythms of its downstream genes. The findings also suggest that time-dependent ERK activation controls the oscillation of ROR gamma and metabolic genes through hnRNP K.
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yu-Chen Pai, Yi-Hsuan Li, Jerrold R. Turner, Linda Chia-Hui Yu
Summary: Factors contributing to inflammatory bowel disease (IBD) include genetic polymorphisms, barrier loss, and microbial dysbiosis. This study found that barrier dysfunction leads to dysbiosis, expansion of invasive microbes, circadian disruption, and mucosal inflammation. This suggests that barrier-protective or bacterium-targeted precision medicine approaches may be beneficial for IBD patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Cell Biology
Austin E. Gillen, L. Elaine Epperson, David J. Orlicky, Rui Fu, Sandra L. Martin
Summary: This study utilized RNA-seq to analyze the gene expression dynamics of adrenal glands in hibernating ground squirrels and found that seasonal differentiation affected the expression of multiple genes involved in steroidogenesis. Additionally, during each short arousal period, an immediate early response gene was activated, which further activated a cellular stress response program to restore protein homeostasis and tissue-specific gene expression.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Immunology
Christophe M. Capelle, Anna Chen, Ni Zeng, Alexandre Baron, Kamil Grzyb, Thais Arns, Alexander Skupin, Markus Ollert, Feng Q. Hefeng
Summary: The stress hormones have an intrinsic role in regulating the differentiation balance of CD4 T cells through inhibiting mTORC1 signaling via effects on the PI3K/AKT pathway and the expression of PER1, a circadian rhythm gene.
Article
Cardiac & Cardiovascular Systems
Chongxu Shi, Danyang Zhao, Lyuben Lyubenov, Manga Motrapu, Na Li, Stefanie Steiger, Elmina Mammadova-Bach, Luying Yang, Dong Liu, Hans-Joachim Anders
Summary: Cholesterol crystal embolism-induced acute kidney injury is dependent on circadian rhythm and associated with cyclic differences in neutrophil function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Seung Hyun Kim, Chul Ho Chang, Jeong-Rim Lee, Seok Kyo Seo, Young In Kwon, Jae Hoon Lee
Summary: The effect of ANI monitor-based intraoperative nociception control was evaluated in laparoscopic surgeries in the Trendelenburg position. The study found that ANI group had significantly higher levels of serum cortisol at the end of surgery compared to the control group, although more remifentanil was administered in the ANI group. Changes in other estimators' levels and postoperative clinical outcomes were comparable between the two groups. However, differences in hemodynamic profiles were observed.
FRONTIERS IN MEDICINE
(2023)
Review
Cell Biology
Deepak Kumar, Ashish Sharma, Rajeev Taliyan, Maiko T. Urmera, Oscar Herrera-Calderon, Thomas Heinbockel, Shafiqur Rahman, Rohit Goyal
Summary: Circadian rhythms are regulated by the master clock in the suprachiasmatic nucleus, entrained to the light-dark cycle by the retino-hypothalamic tract. Disruption of circadian rhythms due to unhealthy lifestyle and chronic photic disturbances has been linked to Alzheimer's disease. The presence of endocannabinoids in CRd-induced Alzheimer's disease has been identified as a potential target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Public, Environmental & Occupational Health
Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschueren, Wing-Yee Lo, Pascal Guenel, Therese Truong, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L. Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Jonine D. Figueroa, Montserrat Garcia-Closas, Mark S. Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L. Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubinski, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C. Southey, Wei Zheng, Alison M. Dunning, Paul D. P. Pharoah, Per Hall, Douglas F. Easton, Thomas Bruening, Hiltrud Brauch, Volker Harth, Sylvia Rabstein
Summary: Light-at-night affects the biosynthesis and secretion of melatonin, which may increase the risk of breast cancer. This study used a large-scale molecular epidemiology approach to investigate the associations between polymorphisms in melatonin biosynthesis/signaling genes and breast cancer risk. The results suggest that SNPs in TPH2 and MAPK genes may impact the circadian regulation network and contribute to elevated breast cancer risks.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Immunology
Guillaume Harle, Camille Kowalski, Juan Dubrot, Dale Brighouse, Gaelle Clavel, Robert Pick, Natacha Bessis, Jennifer Niven, Christoph Scheiermann, Monique Gannage, Stephanie Hugues
Summary: The study reveals that autophagy in LECs plays a crucial role in modulating T cell activation in arthritis, potentially affecting T reg cell populations and S1P production to influence the migration of pathogenic T cells and inflammation development.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Anastasia O. Gkountidi, Laure Garnier, Juan Dubrot, Julien Angelillo, Guillaume Harle, Dale Brighouse, Ludovic J. Wrobel, Robert Pick, Christoph Scheiermann, Melody A. Swartz, Stephanie Hugues
Summary: This study demonstrates that tumoral lymphatic endothelial cells (LEC) can promote tumor growth by upregulating MHC class II and antigen-processing machinery, leading to Treg expansion and suppression of effector T-cell infiltration. Lack of MHC class II expression in LECs impairs tumor growth, increases effector T-cell infiltration, and alters Treg-suppressive functions. Antigen presentation by LECs locally in the tumor microenvironment is crucial for promoting Treg-mediated immunosuppression.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Alexander C. West, Yasutaka Mizoro, Shona H. Wood, Louise M. Ince, Marianne Iversen, Even H. Jorgensen, Torfinn Nome, Simen Rod Sandve, Samuel A. M. Martin, Andrew S. I. Loudon, David G. Hazlerigg
Summary: Using single-nuclei RNAseq, this study characterizes the cytological changes in the gill of Atlantic salmon during the smoltification process and seawater transfer. The results reveal a complex cellular composition in the gill during smoltification, with an increase in seawater-adapted cells and a decrease in immune-related cell types. This study provides new insights into the cellular complexity of gill development and suggests unexpected immune reprogramming during smoltification.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Coline Barnoud, Chen Wang, Christoph Scheiermann
Article
Immunology
Chien-Sin Chen, Jasmin Weber, Stephan Jonas Holtkamp, Louise Madeleine Ince, Alba de Juan, Chen Wang, Lydia Lutes, Coline Barnoud, Burak Kizil, Sophia Martina Hergenhan, Johanna Salvermoser, Manuel Lasch, Elisabeth Deindl, Barbara Schraml, Dirk Baumjohann, Christoph Scheiermann
Summary: Peripheral nerve injury can cause immune cell-mediated destruction of the affected nerve, leading to pro-inflammatory effect on lymph node function and expansion. This effect can be rescued by beta 2 adrenergic receptor agonists.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Stephan J. Holtkamp, Louise M. Ince, Coline Barnoud, Madeleine T. Schmitt, Flore Sinturel, Violetta Pilorz, Robert Pick, Stephane Jemelin, Michael Muehlstaedt, Wolf-Henning Boehncke, Jasmin Weber, David Laubender, Julia Philippou-Massier, Chien-Sin Chen, Leonie Holtermann, Dietmar Vestweber, Markus Sperandio, Barbara U. Schraml, Cornelia Halin, Charna Dibner, Henrik Oster, Joerg Renkawitz, Christoph Scheiermann
Summary: The study demonstrates that circadian clocks regulate the infiltration of dendritic cells into skin lymphatics, which is crucial for adaptive immune responses. The migration pattern of dendritic cells is influenced by rhythmic gradients in the expression of chemokines and adhesion molecules in both mice and humans. Targeting the circadian oscillations in skin lymphatic endothelial cells and dendritic cells disrupts the circadian trafficking of dendritic cells.
Review
Immunology
Louise Madeleine Ince
Summary: Biological rhythms play a crucial role in regulating physiological activities and helping organisms adapt to environmental changes for survival advantage. Recent studies have shown circadian rhythms in parasite infections, parasite schizogony, and the manipulation of host rhythms by certain parasites.
PARASITE IMMUNOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Coline Barnoud, Chen Wang, Louise M. Ince, Christoph Scheiermann
Meeting Abstract
Biochemistry & Molecular Biology
Coline Barnoud, Louise M. Ince, Lydia K. Lutes, Robert Pick, Chen Wang, Stephane Jemelin, Christoph Scheiermann
Review
Immunology
Chen Wang, Lydia Kay Lutes, Coline Barnoud, Christoph Scheiermann
Summary: The immune system is regulated by circadian rhythms, and recent advances have identified molecular factors governing these rhythms. The interconnectivity between immune cells and their environment has been found to be highly complex.
SCIENCE IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
C. Wang, C. Barnoud, B. Kizil, C. Scheiermann
ANNALS OF ONCOLOGY
(2022)
Review
Neurosciences
Francesco De Virgiliis, Valeria Maria Oliva, Burak Kizil, Christoph Scheiermann
Summary: The nervous system communicates with immune cells through neurotransmitters and neuropeptides to respond to immune threats and maintain system homeostasis. Lymph nodes, as the sites of adaptive immune responses, are extensively innervated by peripheral nerves that secrete neurotransmitters and neuropeptides. Time-dependent fluctuations in nerve activity may play a role in coordinating immunity in a circadian fashion.
TRENDS IN NEUROSCIENCES
(2022)
Article
Multidisciplinary Sciences
Louise Madeleine Ince, Coline Barnoud, Lydia Kay Lutes, Robert Pick, Chen Wang, Flore Sinturel, Chien-Sin Chen, Alba de Juan, Jasmin Weber, Stephan J. Holtkamp, Sophia Martina Hergenhan, Jennifer Geddes-McAlister, Stefan Ebner, Paola Fontannaz, Benjamin Meyer, Maria Vono, Stephane Jemelin, Charna Dibner, Claire-Anne Siegrist, Felix Meissner, Frederik Graw, Christoph Scheiermann
Summary: The study shows that circadian rhythms affect immune responses, including responses to vaccines. Dendritic cells migrate in a time-of-day-dependent manner, altering interactions with T cells and influencing vaccine responses. The findings provide a mechanistic understanding of the development and maintenance of an adaptive immune response under circadian control, offering a strategy for optimizing vaccination regimes based on time-of-day.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Laure Garnier, Robert Pick, Julien Montorfani, Mengzhu Sun, Dale Brighouse, Nicolas Liaudet, Thomas Kammertoens, Thomas Blankenstein, Nicolas Page, Jeremiah Bernier-Latamani, Ngoc Lan Tran, Tatiana Petrova, Doron Merkler, Christoph Scheiermann, Stephanie Hugues
Summary: A study found that cytotoxic T cells can reduce lymphatic flow and lymph node metastasis by affecting the tumor lymphatic vessel system. This is achieved through the induction of apoptosis in tumor-associated lymphatic endothelial cells (LECs) by T cells, which is triggered by the release of tumor antigens from dying tumor cells and cross-presentation by LECs.
Letter
Multidisciplinary Sciences
Lucrecia K. Aguilar