Frontline Science: High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

From obesity to diabetes and cancer: epidemiological links and role of therapies

(2016) Custodia García-Jiménez et al.   BRITISH JOURNAL OF CANCER

Obesity and Cancer: The Oil that Feeds the Flame

(2016) Joan Font-Burgada et al.   Cell Metabolism

Multifaceted Breast Cancer: The Molecular Connection With Obesity

(2016) Antonia Feola et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

(2016) Daniel W. Beury et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: Myeloid-derived suppressor cells (MDSCs) facilitate maternal–fetal tolerance in mice

(2016) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Obesity and Cancer: Local and Systemic Mechanisms

(2015) Neil M. Iyengar et al.   Annual Review of Medicine

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

(2015) Yi Zhou et al.   Cell Metabolism

Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype

(2015) Natascha Köstlin et al.   JOURNAL OF IMMUNOLOGY

Obesity and cancer pathogenesis

(2014) Nathan A. Berger   Annals of the New York Academy of Sciences

The Microbiome and Obesity—An Established Risk for Certain Types of Cancer

(2014) Connie J. Rogers et al.   CANCER JOURNAL

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

(2014) Koji Taniguchi et al.   SEMINARS IN IMMUNOLOGY

Leptin Receptor Mutation Results in Defective Neutrophil Recruitment to the Colon during Entamoeba histolytica Infection

(2014) Caitlin Naylor et al.   mBio

Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway

(2013) Dehong Yan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells

(2013) Pedro M.M. Moraes-Vieira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

(2013) Moshe Sade-Feldman et al.   IMMUNITY

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

(2013) Chris P. Verschoor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

(2013) Nana-Maria Wagner et al.   Obesity

Obesity Is Associated with Neutrophil Dysfunction and Attenuation of Murine Acute Lung Injury

(2012) Lauren L. Kordonowy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC)

(2012) Suzanne Ostrand-Rosenberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice

(2012) Chi Ma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression

(2012) Suzanne Ostrand-Rosenberg et al.   SEMINARS IN CANCER BIOLOGY

Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions

(2011) Christiane D. Wrann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL

(2011) P. Sinha et al.   BLOOD

Gr-1+CD11b+Myeloid-derived Suppressor Cells Suppress Inflammation and Promote Insulin Sensitivity in Obesity

(2011) Sheng Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

A Role for Immature Myeloid Cells in Immune Senescence

(2010) E. Y. Enioutina et al.   JOURNAL OF IMMUNOLOGY

Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

(2009) R. C.M. van Kruijsdijk et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

(2009) E. M. Hanson et al.   JOURNAL OF IMMUNOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE