Review
Immunology
Kellie A. Mouchemore, Robin L. Anderson
Summary: G-CSF has been reported to play a pro-tumour role in cancer by mainly affecting neutrophils and MDSCs, suppressing T cells in the presence of G-CSF. Recent studies have also highlighted other tumour-promoting effects of G-CSF on myeloid cells, raising concerns about its impact on anti-cancer treatments like immune checkpoint blockade.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Oncology
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang
Summary: Chronic stress promotes lung metastasis in breast cancer by remodeling the pre-metastatic niche through increased expression of vesicular acetylcholine transporter, acetylcholine, and peptidylarginine deiminase 4. Chronic stress also alters lung immune cell subsets, increases neutrophils, promotes NETosis, and enhances neutrophil capture of cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Sergi Masgrau-Alsina, Lou Martha Wackerbarth, Dae-sik Lim, Markus Sperandio
Summary: This study identifies MST1 as a critical regulator of neutrophil homeostasis and mobilization from the bone marrow, shedding light on its complex role in regulating innate immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Maria Mulet, Ruben Osuna-Gomez, Carlos Zamora, Jose M. Porcel, Juan C. Nieto, Lidia Perea, Virginia Pajares, Ana M. Munoz-Fernandez, Nuria Calvo, Maria Alba Sorolla, Silvia Vidal
Summary: This study provides novel information about the role of neutrophils in malignant pleural effusion (MPE) and their clinical relevance. Neutrophils contribute to tumor progression through the release of neutrophil extracellular traps (NETs) and are associated with worse outcomes in lung adenocarcinoma patients with MPE.
Article
Immunology
Sara Artigas-Jeronimo, Almudena Gonzalez-Garcia, Jose de la Fuente, Valeria Blanda, Mojtaba Shekarkar Azgomi, Margarita Villar, Leila Mohammadnezhad, Francesca Grippi, Alessandra Torina, Guido Sireci
Summary: This study conducted bioinformatics analysis to further characterize the interactions between Anaplasma phagocytophilum and its host. The results revealed the overrepresentation of proteins involved in the reactive oxygen species pathway and cell surface monocyte markers in infected human cells. This may induce cell death and the formation of neutrophil extracellular traps as defense mechanisms against invading microorganisms.
Article
Chemistry, Multidisciplinary
Penghui Cheng, Shasha He, Chi Zhang, Jing Liu, Kanyi Pu
Summary: A tandem-locked NETosis reporter was developed for specific imaging of NETosis. This reporter can differentiate NETosis from neutrophil activation and provide prognosis for cancer immunotherapy. The study demonstrates a sensitive optical reporter for noninvasive monitoring of NETosis levels and evaluation of cancer immunotherapeutic efficacy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Supriya Chakraborty, Zeynab Tabrizi, Nairuti Nikhil Bhatt, Sofia Andrea Franciosa, Oliver Bracko
Summary: Neutrophils, the most prevalent leukocytes in the bloodstream, play a crucial role in the initial defense against infections or injuries. They perform various functions, such as engulfing microorganisms, releasing inflammatory molecules, generating oxidative burst, and forming neutrophil extracellular traps. Recent studies have challenged the traditional view of neutrophils as static responders with a short lifespan, revealing their heterogeneity and dynamic response. This article focuses on discussing their involvement in aging and neurological disorders, particularly emphasizing their impact on chronic inflammation and contribution to neurological diseases. It concludes that reactive neutrophils directly contribute to increased vascular inflammation and age-related diseases.
Article
Biochemistry & Molecular Biology
Stavros Giaglis, Chanchal Sur Chowdhury, Shane Vontelin van Breda, Maria Stoikou, Andre N. Tiaden, Douglas Daoudlarian, Guenther Schaefer, Andreas Buser, Ulrich A. Walker, Olav Lapaire, Irene Hoesli, Paul Hasler, Sinuhe Hahn
Summary: Pregnancy is associated with increased levels of cell-free DNA of neutrophil extracellular trap (NET) origin, mainly driven by G-CSF and sex hormones. In contrast, the postpartum period is characterized by elevated markers of neutrophil degranulation and NET release, indicating a pro-NETotic and potentially procoagulant nature of postpartum neutrophils which may lead to harmful thrombotic incidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hannah D. Stacey, Diana Golubeva, Alyssa Posca, Jann C. Ang, Kyle E. Novakowski, Muhammad Atif Zahoor, Charu Kaushic, Ewa Cairns, Dawn M. E. Bowdish, Caitlin E. Mullarkey, Matthew S. Miller
Summary: IgA plays a key role in protecting against viral infections by potentiating NETosis through neutrophils, which release neutrophil extracellular traps (NETs) to trap and inactivate viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Zimam Mahmud, Atiqur Rahman, Israt Dilruba Mishu, Yearul Kabir
Summary: Cancer is a major global public health issue characterized by uncontrolled division of abnormal cells. Neutrophils, the most abundant leukocytes in human blood, play a crucial role in immune defense but can also promote tumor metastasis, angiogenesis, and immunosuppression.
CANCER AND METASTASIS REVIEWS
(2022)
Review
Immunology
Ziming Cao, Meng Zhao, Hao Sun, Liang Hu, Yunfeng Chen, Zhichao Fan
Summary: This review focuses on the significant role of mitochondria in neutrophil functions and related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Andrea Murru, Marie-eve Allard, Guillaume Pare, Myriam Vaillancourt, Lucie Boyer, Marie-Pierre Cayer, Julien Vitry, Patricia Landry, Marie-Michele Labrecque, Nancy Robitaille, Donald R. Branch, Melissa Girard, Maria J. Fernandes
Summary: This study compared the functional differences of neutrophils in prednisone and G-CSF GCs prepared by leukapheresis. The results showed that G-CSF GCs contained a higher number of neutrophils, but 40% of them were immature. Prednisone GC neutrophils showed enhanced phagocytosis compared to healthy donors, while G-CSF GC neutrophils exhibited decreased chemotaxis but increased IL-8 production. Leukapheresis and storage had significant impacts on the function of prednisone and G-CSF GC neutrophils.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Lydia C. Powell, Jason K. Cullen, Glen M. Boyle, Tom De Ridder, Pei-Yi Yap, Wenya Xue, Carly J. Pierce, Manon F. Pritchard, Georgina E. Menzies, Muthanna Abdulkarim, Jennifer Y. M. Adams, Joana Stokniene, Lewis W. Francis, Mark Gumbleton, Jenny Johns, Katja E. Hill, Adam V. Jones, Peter G. Parsons, Paul Reddell, David W. Thomas
Summary: This study reports a non-antibiotic approach using naturally occurring and semisynthetic compounds to treat chronic skin wounds by modifying bacterial growth and inducing biofilm disruption. The compounds were found to stimulate immune responses and exhibit antimicrobial activity, leading to the resolution of infection and wound healing.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Hrishikesh M. Mehta, Seth J. Corey
Summary: A significant amount of continuous proliferation and differentiation is needed in adults to generate a billion new neutrophils daily, with G-CSF playing a crucial role in controlling granulopoiesis. CSF3R mutations are linked to various human disorders related to neutrophil production, including severe congenital neutropenia and myeloid malignancies. Despite more than thirty years since the discovery and characterization of G-CSF and G-CSF receptor, there are still fundamental questions about their physiological functions that remain unanswered.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hai Zhong, Huiyi Liang, Yanzi Yan, Lei Chen, Tianyu Zhao, Lixin Liu, Yongming Chen
Summary: Chronic inflammation is a major obstacle in refractory diabetic foot ulcers, with high levels of cfDNA playing a crucial role in inflammation. Using cationic hydrogels can significantly reduce cfDNA levels, eliminate inflammation, promote wound closure, and does not introduce systemic toxicity.
Review
Oncology
Merav E. Shaul, Zvi G. Fridlender
NATURE REVIEWS CLINICAL ONCOLOGY
(2019)
Article
Respiratory System
Arschang Valipour, Michael Tamm, Jana Kocianova, Valentina Bayer, Maria Sanzharovskaya, Alexey Medvedchikov, Monika Haaksma-Herczegh, Janos Mucsi, Zvi Fridlender, Claudia Toma, Andrey Belevskiy, Bohumil Matula, Jurij Sorli
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2019)
Article
Cell Biology
Dmytro Petukhov, Mark Richter-Dayan, Zvi Fridlender, Raphael Breuer, Shulamit B. Wallach-Dayan
Article
Respiratory System
Arschang Valipour, Sergey Avdeev, Adam Barczyk, Valentina Bayer, Zvi Fridlender, Mariela Georgieva, Alexey Medvedchikov, Ramona Miron, Maria Sanzharovskaya, Jurij Sorli, Marc Spielmanns, Zsuzsanna Szalai, Ondrej Kudela, Virginija Sileikiene
Summary: The study investigated changes in CCQ score during treatment with tiotropium/olodaterol in clinical practice, showing a therapeutic success rate of 81.4% and an improvement of 1.02 points in CCQ score after treatment.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Oncology
Christopher Groth, Ludovica Arpinati, Merav E. Shaul, Nina Winkler, Klara Diester, Nicolas Gengenbacher, Rebekka Weber, Ihor Arkhypov, Samantha Lasser, Vera Petrova, Hellmut G. Augustin, Peter Altevogt, Jochen Utikal, Zvi G. Fridlender, Viktor Umansky
Summary: Myeloid-derived suppressor cells (MDSC) are a heterogeneous myeloid cell population expanded in tumor-bearing hosts and contribute to immunosuppression, making them a valuable therapeutic target. In melanoma, both polymorphonuclear (PMN) and monocytic (M) MDSC subsets have comparable immunosuppressive activities, with PMN-MDSC recruitment mediated by the CXCR2/CXCL1 axis. Inhibiting CXCR2 decreases PMN-MDSC infiltration, improves survival, and reduces metastasis, suggesting a critical role of PMN-MDSC in suppressing the NK cell-mediated anti-tumor response.
Review
Immunology
Daniela F. Quail, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andres Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Irina A. Udalova, Timo K. van den Berg, Denisa D. Wagner, Ping Wang, Arturo Zychlinsky, Karin E. de Visser, Mikala Egeblad, Paul Kubes
Summary: This article discusses the functional states and heterogeneity of neutrophils in cancer and provides a consensus statement on the controversies and solutions in neutrophil research. Further research is needed to understand the role of neutrophils in cancer and explore potential novel opportunities for cancer treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Medicine, General & Internal
Roukhama Fedidat, Anna Elia, Alon Hershko, Zvi Fridlender
Summary: Kaposiform lymphangiomatosis (KLA) is a rare lymphatic anomaly that mainly affects the mediastinum and lungs, but can also involve other extrathoracic organs. There is limited understanding of its pathophysiology, natural history, treatment response, and long-term outcome. We present a case of an adult male with 13 years of recurrent episodes of haemoptysis who was diagnosed with KLA. A comprehensive literature review is provided.