The evolution of regulated cell death pathways in animals and their evasion by pathogens

Activation mechanisms of inflammasomes by bacterial toxins

(2021) Weidong Jing et al.   CELLULAR MICROBIOLOGY

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

(2021) Zhijun Liu et al.   IMMUNITY

Lessons from the host defences of bats, a unique viral reservoir

(2021) Aaron T. Irving et al.   NATURE

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

(2021) Qin Gong et al.   Nature Communications

Diverse viral proteases activate the NLRP1 inflammasome

(2021) Brian V Tsu et al.   eLife

The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis

(2021) Xia-lian Wu et al.   Nature Communications

Key Components of Inflammasome and Pyroptosis Pathways Are Deficient in Canines and Felines, Possibly Affecting Their Response to SARS-CoV-2 Infection

(2021) Haoran Cui et al.   Frontiers in Immunology

SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation

(2021) Na-Eun Kim et al.   Microorganisms

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

(2021) Grant R. Campbell et al.   iScience

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

(2021) André C. Ferreira et al.   Cell Death Discovery

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

(2021) Menghang Huang et al.   NATURE

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

(2021) Teodora Oltean et al.   Cell Death & Disease

Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

(2021) Elke De Schutter et al.   TRENDS IN CELL BIOLOGY

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

(2021) Hin Chu et al.   Science Advances

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation

(2020) Graeme P. Sullivan et al.   DEVELOPMENTAL CELL

Death Receptors and Their Ligands in Inflammatory Disease and Cancer

(2020) Alessandro Annibaldi et al.   Cold Spring Harbor Perspectives in Biology

NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation

(2020) Fangwei Leng et al.   Scientific Reports

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation

(2020) Valentina C. Sladky et al.   CELL DEATH AND DIFFERENTIATION

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

(2020) Robin Schwarzer et al.   CURRENT OPINION IN CELL BIOLOGY

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

(2020) Bart Tummers et al.   IMMUNITY

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Controlling Cell Death through Post-translational Modifications of DED Proteins

(2020) Kamil Seyrek et al.   TRENDS IN CELL BIOLOGY

The Role of Caspase-2 in Regulating Cell Fate

(2020) Vasanthy Vigneswara et al.   Cells

Cellular Mechanisms of NETosis

(2020) Hawa Racine Thiam et al.   Annual Review of Cell and Developmental Biology

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8

(2020) Hiroshi Ashida et al.   EMBO JOURNAL

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Min Zheng et al.   IMMUNOLOGICAL REVIEWS

Increasing complexity of NLRP3 inflammasome regulation

(2020) Julien Moretti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting the NLRP3 Inflammasome in Severe COVID-19

(2020) Tracey L. Freeman et al.   Frontiers in Immunology

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

(2020) Rosalie Heilig et al.   Life Science Alliance

Necroptosis restricts influenza A virus as a stand-alone cell death mechanism

(2020) Maria Shubina et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

(2020) Venkat Giri Magupalli et al.   SCIENCE

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

(2020) Kim S. Robinson et al.   SCIENCE

Crystal structure of caspase-11 CARD provides insights into caspase-11 activation

(2020) Muziying Liu et al.   Cell Discovery

Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

(2020) Matteo Burigotto et al.   EMBO JOURNAL

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

(2020) Tamara S. Rodrigues et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human NLRP1 is a sensor for double-stranded RNA

(2020) Stefan Bauernfried et al.   SCIENCE

Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

(2020) Maria Jesús García-Murria et al.   Nature Communications

Coral gasdermin triggers pyroptosis

(2020) Shuai Jiang et al.   Science Immunology

Characterization of pyrin dephosphorylation and inflammasome activation in macrophages as triggered by the Yersinia effectors YopE and YopT

(2019) Natasha P. Medici et al.   INFECTION AND IMMUNITY

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

(2019) Matae Ahn et al.   Nature Microbiology

Interactions Between Enteroviruses and the Inflammasome: New Insights Into Viral Pathogenesis

(2019) Xia Xiao et al.   Frontiers in Microbiology

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin

(2019) Hao Xu et al.   EMBO JOURNAL

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1

(2019) Justin P. Ingram et al.   JOURNAL OF IMMUNOLOGY

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

(2019) Ayaz Najafov et al.   MOLECULAR CELL

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Suicidal selection: Programmed cell death can evolve in unicellular organisms due solely to kin selection

(2019) Anya E. Vostinar et al.   Ecology and Evolution

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

(2019) Emma J. Petrie et al.   Cell Reports

The Pyrin Inflammasome in Health and Disease

(2019) Oskar Schnappauf et al.   Frontiers in Immunology

Zebrafish in Inflammasome Research

(2019) Gabriel Forn-Cuní et al.   Cells

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

The Evolutionary Origins of Programmed Cell Death Signaling

(2019) Kay Hofmann   Cold Spring Harbor Perspectives in Biology

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

(2019) Saskia D. Günther et al.   Nature Microbiology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Functional and structural characterization of zebrafish ASC

(2018) Yajuan Li et al.   FEBS Journal

Coxiella burnetii Inhibits Neutrophil Apoptosis by Exploiting Survival Pathways and Antiapoptotic Protein Mcl-1

(2018) Rama Cherla et al.   INFECTION AND IMMUNITY

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

(2018) Teneema Kuriakose et al.   JOURNAL OF IMMUNOLOGY

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8

(2018) Vitaliya Sagulenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death

(2018) Mark Lötzerich et al.   Cell Death & Disease

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

(2018) Xiaolan Liu et al.   Cell Death & Disease

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

(2018) Brice Lagrange et al.   Nature Communications

Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation

(2018) Sarah N. Croft et al.   Scientific Reports

PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis

(2018) Eusondia Arnett et al.   PLoS Pathogens

Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen

(2018) Karina K. Sanchez et al.   CELL

Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates

(2018) Jiang-yuan Li et al.   JOURNAL OF IMMUNOLOGY

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

The CaspBase: A curated database for evolutionary biochemical studies of caspase functional divergence and ancestral sequence inference

(2018) Robert D. Grinshpon et al.   PROTEIN SCIENCE

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

(2018) Yuan Yue et al.   Cell Death & Disease

Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

(2018) Dahai Yang et al.   Nature Communications

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

(2018) Hideki Hara et al.   CELL

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)

(2017) Nichollas E. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

(2017) Kiyohiro Ando et al.   JOURNAL OF CELL BIOLOGY

The resurrection of the PIDDosome – emerging roles in the DNA-damage response and centrosome surveillance

(2017) Valentina Sladky et al.   JOURNAL OF CELL SCIENCE

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

(2017) Kimberley D. Gutierrez et al.   JOURNAL OF IMMUNOLOGY

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

(2017) Torsten Hartwig et al.   MOLECULAR CELL

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

(2017) Shu Zhu et al.   NATURE

Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice

(2017) Suzan L. Harris et al.   NEUROSCIENCE

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

(2017) Heather Koehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome

(2017) Yvan Jamilloux et al.   RHEUMATOLOGY

Evolutionary Convergence and Divergence in NLR Function and Structure

(2017) Etienne Meunier et al.   TRENDS IN IMMUNOLOGY

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

(2017) S. J. Anthony et al.   mBio

The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited

(2017) Qing Xu et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

(2017) Annette Fischer et al.   eLife

Bacterial Secretant from Pseudomonas aeruginosa Dampens Inflammasome Activation in a Quorum Sensing-Dependent Manner

(2017) Jungmin Yang et al.   Frontiers in Immunology

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

The Paracaspase MALT1

(2016) Janna Hachmann et al.   BIOCHIMIE

Functional conservation of the apoptotic machinery from coral to man: the diverse and complex Bcl-2 and caspase repertoires of Acropora millepora

(2016) Aurelie Moya et al.   BMC GENOMICS

Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism

(2016) Janelle S. Ayres   CELL

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Infection of epithelial cells withChlamydia trachomatisinhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact

(2016) Collins Waguia Kontchou et al.   CELLULAR MICROBIOLOGY

Just So Stories about the Evolution of Apoptosis

(2016) Douglas R. Green et al.   CURRENT BIOLOGY

Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system

(2016) Seamus J. Martin   FEBS Journal

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

(2016) Ine Jorgensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reassessing the Evolutionary Importance of Inflammasomes

(2016) Vivien I. Maltez et al.   JOURNAL OF IMMUNOLOGY

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

(2016) Miyu Moriyama et al.   JOURNAL OF VIROLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells

(2016) M A Pallett et al.   Mucosal Immunology

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis

(2016) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

An evolutionary perspective on the necroptotic pathway

(2016) Yves Dondelinger et al.   TRENDS IN CELL BIOLOGY

Global Patterns of Zoonotic Disease in Mammals

(2016) Barbara A. Han et al.   TRENDS IN PARASITOLOGY

Epstein-Barr viral microRNAs target caspase 3

(2016) Cecelia Harold et al.   Virology Journal

The HET-S/s Prion Motif in the Control of Programmed Cell Death

(2016) Roland Riek et al.   Cold Spring Harbor Perspectives in Biology

The inhibition of the apoptosis pathway by theCoxiella burnetiieffector protein CaeA requires the EK repetition motif, but is independent of survivin

(2016) Stephanie Bisle et al.   Virulence

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFNγ- and TNFα-Mediated Antiproliferative Effects and Necroptosis

(2016) Wenbo Ma et al.   Frontiers in Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

(2015) Sedigheh Delmaghani et al.   CELL

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

The paracaspase MALT1: biological function and potential for therapeutic inhibition

(2015) Maike Jaworski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT)

(2015) Dale Carpenter et al.   JOURNAL OF NEUROVIROLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Breakdown of coral colonial form under reduced pH conditions is initiated in polyps and mediated through apoptosis

(2015) Hagit Kvitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

(2015) P Geserick et al.   Cell Death & Disease

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome

(2015) Woo-Chang Cheong et al.   PLoS One

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

RIP kinases: key decision makers in cell death and innate immunity

(2014) F Humphries et al.   CELL DEATH AND DIFFERENTIATION

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

(2014) M. Andree et al.   EMBO JOURNAL

Human cytomegalovirus suppresses Fas expression and function

(2014) S. Seirafian et al.   JOURNAL OF GENERAL VIROLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

The Apoptotic Initiator Caspase-8: Its Functional Ubiquity and Genetic Diversity during Animal Evolution

(2014) Kazuhiro Sakamaki et al.   MOLECULAR BIOLOGY AND EVOLUTION

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of TNF-induced apoptosis reveals 550 My of functional conservation

(2014) Steven D. Quistad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many players in BCL-2 family affairs

(2014) Tudor Moldoveanu et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection

(2013) Taira Kobayashi et al.   Cell Host & Microbe

Revisiting Caspase-11 Function in Host Defense

(2013) Tessie M. Ng et al.   Cell Host & Microbe

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-2 at a glance

(2013) L. L. Fava et al.   JOURNAL OF CELL SCIENCE

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

(2013) K. E. Johnson et al.   JOURNAL OF VIROLOGY

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation

(2013) I. Paciello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

(2013) H. Walczak   Cold Spring Harbor Perspectives in Biology

Caspase Substrates and Inhibitors

(2013) M. Poreba et al.   Cold Spring Harbor Perspectives in Biology

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Calpain Activation by the Shigella flexneri Effector VirA Regulates Key Steps in the Formation and Life of the Bacterium's Epithelial Niche

(2012) Jean Bergounioux et al.   Cell Host & Microbe

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

TheCoxiella burnetiitype IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level

(2012) Leonie Klingenbeck et al.   CELLULAR MICROBIOLOGY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

(2012) Kuo-Chieh Liao et al.   INFECTION AND IMMUNITY

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial pathway of apoptosis is ancestral in metazoans

(2012) C. E. Bender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

(2012) G. Zhang et al.   SCIENCE

The pantheon of the fallen: why are there so many forms of cell death?

(2012) Douglas R. Green et al.   TRENDS IN CELL BIOLOGY

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL

(2012) M Grunert et al.   Cell Death & Disease

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

(2012) Carolin Seuring et al.   PLOS BIOLOGY

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

(2011) Cristina Pop et al.   BIOCHEMICAL JOURNAL

Metacaspases

(2011) L Tsiatsiani et al.   CELL DEATH AND DIFFERENTIATION

Fas death receptor signalling: roles of Bid and XIAP

(2011) T Kaufmann et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2: the orphan caspase

(2011) L Bouchier-Hayes et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cytochrome c: the Achilles’ heel in apoptosis

(2011) A. V. Kulikov et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIF-1α is involved in mediating apoptosis resistance to Chlamydia trachomatis-infected cells

(2011) Manu Sharma et al.   CELLULAR MICROBIOLOGY

Trans genomic capture and sequencing of primate exomes reveals new targets of positive selection

(2011) R. D. George et al.   GENOME RESEARCH

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1  Secretion

(2011) N. Komune et al.   JOURNAL OF VIROLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

(2011) Andrew Oberst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

(2011) S. M. Gregory et al.   SCIENCE

The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8

(2010) Florent Dufour et al.   APOPTOSIS

Activation and Specificity of Human Caspase-10

(2010) Katherine Wachmann et al.   BIOCHEMISTRY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins

(2010) Margherita Lasi et al.   CELL RESEARCH

A whodunit: an appointment with death

(2010) Alessandra Giodini et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein

(2010) A. Luhrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo

(2010) Linda Zane et al.   Retrovirology

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

Anaplasma phagocytophilum Ats-1 Is Imported into Host Cell Mitochondria and Interferes with Apoptosis Induction

(2010) Hua Niu et al.   PLoS Pathogens

Apoptosis in pre-Bilaterians: Hydra as a model

(2009) Margherita Lasi et al.   APOPTOSIS

The zebrafish as a model organism for the study of apoptosis

(2009) Peter M. Eimon et al.   APOPTOSIS

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins

(2009) M Çam et al.   CELL DEATH AND DIFFERENTIATION

Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells

(2009) Leticia A.M. Carneiro et al.   Cell Host & Microbe

Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments

(2009) Yadunanda Kumar et al.   Cell Host & Microbe

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

(2009) Fang Yan et al.   GASTROENTEROLOGY

Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor

(2009) Dayong Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Caspases: evolutionary aspects of their functions in vertebrates

(2009) K. Sakamaki et al.   JOURNAL OF FISH BIOLOGY

The Full-Length Isoform of Human Papillomavirus 16 E6 and Its Splice Variant E6* Bind to Different Sites on the Procaspase 8 Death Effector Domain

(2009) S. S. Tungteakkhun et al.   JOURNAL OF VIROLOGY

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Life on the inside: the intracellular lifestyle of cytosolic bacteria

(2009) Katrina Ray et al.   NATURE REVIEWS MICROBIOLOGY

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

(2009) A. L. Desbien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of procaspase-8 activation by c-FLIPL

(2009) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Evolution of Intracellular Pathogens

(2008) Arturo Casadevall   Annual Review of Microbiology

The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization

(2008) Damien Arnoult et al.   APOPTOSIS

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis

(2008) Zhongde Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of apoptosis in Drosophila

(2008) H Steller   CELL DEATH AND DIFFERENTIATION

Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1

(2008) Jason W. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire

(2008) L. Eckhart et al.   MOLECULAR BIOLOGY AND EVOLUTION

Intracellular pathogenic bacteria and fungi — a case of convergent evolution?

(2008) James B. Bliska et al.   NATURE REVIEWS MICROBIOLOGY

Cytochrome c: functions beyond respiration

(2008) Yong-Ling P. Ow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expansion and evolution of cell death programmes

(2008) Alexei Degterev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of apoptosis in human laryngeal cancer cells by E6 and E7 oncoproteins of human papillomavirus 16

(2007) Han Ching Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY