Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass

(2018) Lei Hou et al.   LABORATORY INVESTIGATION

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

(2017) Boris M. Hartmann et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Soluble Uric Acid Activates the NLRP3 Inflammasome

(2017) Tarcio Teodoro Braga et al.   Scientific Reports

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

(2017) Danielle P. A. Mascarenhas et al.   PLoS Pathogens

Apoptotic Cells Induced Signaling for Immune Homeostasis in Macrophages and Dendritic Cells

(2017) Uriel Trahtemberg et al.   Frontiers in Immunology

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model

(2017) Daniela Carlos et al.   Frontiers in Immunology

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

Self-extracellular RNA acts in synergy with exogenous danger signals to promote inflammation

(2017) Frederik Noll et al.   PLoS One

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The killer protein Gasdermin D

(2016) John A Wright et al.   CELL DEATH AND DIFFERENTIATION

Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes

(2016) C B Medina et al.   CELL DEATH AND DIFFERENTIATION

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

An outline of necrosome triggers

(2016) Tom Vanden Berghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis

(2016) Ine Jorgensen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Monocytes Take Their Own Path to IL-1β

(2016) Eric I. Elliott et al.   IMMUNITY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo

(2016) Isabella Rauch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice

(2016) Yue Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

(2016) Ine Jorgensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peroxiredoxin 1 Contributes to Host Defenses againstMycobacterium tuberculosis

(2016) Kazunori Matsumura et al.   JOURNAL OF IMMUNOLOGY

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Release mechanism of high mobility group nucleosome binding domain 1 from lipopolysaccharide-stimulated macrophages

(2016) TAISUKE MURAKAMI et al.   Molecular Medicine Reports

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Apoptosis in response to microbial infection induces autoreactive TH17 cells

(2016) Laura Campisi et al.   NATURE IMMUNOLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells

(2016) Valentina Salvestrini et al.   Oncotarget

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity

(2016) Stuart K. Calderwood et al.   Frontiers in Immunology

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection

(2015) Isa Muñoz-Arias et al.   Cell Host & Microbe

RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice

(2015) Zhe Huang et al.   Cell Host & Microbe

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Mechanisms of unconventional secretion of IL-1 family cytokines

(2015) Mercedes Monteleone et al.   CYTOKINE

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

S100A9 Induced Inflammatory Responses Are Mediated by Distinct Damage Associated Molecular Patterns (DAMP) Receptors In Vitro and In Vivo

(2015) Bo Chen et al.   PLoS One

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

(2014) S Orozco et al.   CELL DEATH AND DIFFERENTIATION

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis

(2014) Gaurav D. Gaiha et al.   IMMUNITY

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux

(2014) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Toll-Like Receptor (TLR)-1/2 Triggering of Multiple Myeloma Cells Modulates Their Adhesion to Bone Marrow Stromal Cells and Enhances Bortezomib-Induced Apoptosis

(2014) Jahangir Abdi et al.   PLoS One

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals

(2014) A Maeda et al.   Cell Death & Disease

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Correction: Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2014) Marina Tiemi Shio et al.   PLoS Pathogens

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

The HMGB1–TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis

(2013) Hua-Sheng Ding et al.   GENE

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

MyD88 mediates the decision to die by apoptosis or necroptosis after UV irradiation

(2013) Erin Harberts et al.   Innate Immunity

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages

(2013) Qiang Wang et al.   INTERNATIONAL IMMUNOLOGY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin

(2013) Silvia L. Lage et al.   METHODS

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Annexin A1 on the Surface of Early Apoptotic Cells Suppresses CD8+ T Cell Immunity

(2013) Heiko Weyd et al.   PLoS One

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients

(2013) Fu-fan Zhu et al.   OncoTargets and Therapy

Mitochondrial Regulation of Cell Death

(2013) S. W. G. Tait et al.   Cold Spring Harbor Perspectives in Biology

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Type 1 interferon-associated necroptosis: a novel mechanism for Salmonella enterica Typhimurium to induce macrophage death

(2012) Zhi-Qing Hu et al.   Cellular & Molecular Immunology

Pattern recognition receptors—Molecular orchestrators of inflammation in inflammatory bowel disease

(2012) David Walsh et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis

(2012) Sanna Nyström et al.   EMBO JOURNAL

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

Generation of aListeriavaccine strain by enhanced caspase-1 activation

(2011) Sarah E. Warren et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

(2011) Marion C. Bonnet et al.   IMMUNITY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Toll-like Receptor 3 (TLR3) Induces Apoptosis via Death Receptors and Mitochondria by Up-regulating the Transactivating p63 Isoform α (TAP63α)

(2011) Ruili Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses

(2011) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

(2011) J. W. Dear et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

(2011) P Liu et al.   LEUKEMIA

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

(2011) J.-D. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis: A Programme of Cell Death or Cell Disposal?

(2011) W. O. Pereira et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Short RNA Duplexes Elicit RIG-I-Mediated Apoptosis in a Cell Type- and Length-Dependent Manner

(2011) O. Ishibashi et al.   Science Signaling

Decoding Cell Death Signals in Inflammation and Immunity

(2010) Laurence Zitvogel et al.   CELL

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Control of infection by pyroptosis and autophagy: role of TLR and NLR

(2010) Karina R. Bortoluci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Separation of supercoiled from open circular forms of plasmid DNA, and biological activity detection

(2010) Huangjin Li et al.   CYTOTECHNOLOGY

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

(2010) Kodi S. Ravichandran   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

BCR–ABL-mediated upregulation of PRAME is responsible for knocking down TRAIL in CML patients

(2010) D D De Carvalho et al.   ONCOGENE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Regulation of death receptor signaling by the ubiquitin system

(2009) I E Wertz et al.   CELL DEATH AND DIFFERENTIATION

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

(2009) A Weber et al.   CELL DEATH AND DIFFERENTIATION

Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

(2009) Elliott D. Crouser et al.   CRITICAL CARE MEDICINE

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of  -Defensins

(2009) K. Miles et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

(2009) Miriam Beer Torchinsky et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

FLIP and the death effector domain family

(2008) J W Yu et al.   ONCOGENE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE