NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

(2016) Michael C. Gundry et al.   Cell Reports

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

(2016) Diana M Mitrea et al.   eLife

An Inhibitor of PIDDosome Formation

(2015) Ruth Thompson et al.   MOLECULAR CELL

CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

(2015) Miguel A Moreno-Mateos et al.   NATURE METHODS

Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo

(2014) M R Terry et al.   CELL DEATH AND DIFFERENTIATION

Emerging Roles of the Nucleolus in Regulating the DNA Damage Response: The Noncanonical DNA Repair Enzyme APE1/Ref-1 as a Paradigmatical Example

(2013) Giulia Antoniali et al.   ANTIOXIDANTS & REDOX SIGNALING

PIDD mediates and stabilizes the interaction between RAIDD and Caspase-2 for the PIDDosome assembly

(2013) Tae-Ho Jang et al.   BMB Reports

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

(2013) M J Parsons et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 as a tumour suppressor

(2013) J Puccini et al.   CELL DEATH AND DIFFERENTIATION

Regulated unfolding of proteins in signaling

(2013) Diana M. Mitrea et al.   FEBS LETTERS

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice

(2013) J. Puccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

(2013) C Manzl et al.   Cell Death & Disease

PIDDosome-independent tumor suppression by Caspase-2

(2012) C Manzl et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

(2012) L Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

Degradomics Reveals That Cleavage Specificity Profiles of Caspase-2 and Effector Caspases Are Alike

(2012) Magdalena Wejda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

P53-induced protein with a death domain (PIDD): master of puppets?

(2012) F J Bock et al.   ONCOGENE

Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1

(2011) R. Balusu et al.   BLOOD

Caspase-2: the orphan caspase

(2011) L Bouchier-Hayes et al.   CELL DEATH AND DIFFERENTIATION

The PIDDosome, DNA-damage-induced apoptosis and beyond

(2011) S Janssens et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis

(2010) Yu Pan et al.   CANCER BIOLOGY & THERAPY

High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells

(2009) Hyung-song Nam et al.   Cell Stem Cell

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity

(2009) Lisa Bouchier-Hayes et al.   MOLECULAR CELL

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

(2009) Katie Myers et al.   PLoS Genetics

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing

(2008) Sean P. Cullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells

(2008) W Qi et al.   ONCOGENE