The paracaspase MALT1: biological function and potential for therapeutic inhibition

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Probes to Monitor Activity of the Paracaspase MALT1

(2015) Janna Hachmann et al.   CHEMISTRY & BIOLOGY

Activity-Based Probes for Detection of Active MALT1 Paracaspase in Immune Cells and Lymphomas

(2015) Andrea C. Eitelhuber et al.   CHEMISTRY & BIOLOGY

Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation

(2015) Divya Punwani et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphoma

(2015) Zilin Nie et al.   Nature Communications

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

(2015) Jong W. Yu et al.   PLoS One

A catalytic-independent role for the LUBAC in NF- B activation upon antigen receptor engagement and in lymphoma cells

(2014) S. M. Dubois et al.   BLOOD

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

(2014) Maike Jaworski et al.   EMBO JOURNAL

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation

(2014) Xue-Qiang Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

(2014) Andreas Schlundt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

(2014) Mathijs Baens et al.   PLoS One

Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

(2014) Y. Yang et al.   Cancer Discovery

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

(2014) Andreas Gewies et al.   Cell Reports

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

(2013) Florian Schlauderer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Epithelial Growth Factor Receptor–Activated Nuclear Factor κB Signaling and Its Role in Epithelial Growth Factor Receptor–Associated Tumors

(2013) Deng Pan et al.   CANCER JOURNAL

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

(2013) Haifa H. Jabara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

(2013) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination

(2013) C. Mc Guire et al.   JOURNAL OF IMMUNOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination

(2013) Christiane Pelzer et al.   NATURE IMMUNOLOGY

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

(2013) Rami Rahal et al.   NATURE MEDICINE

Diffuse large B-cell lymphoma—treatment approaches in the molecular era

(2013) Mark Roschewski et al.   Nature Reviews Clinical Oncology

Monoubiquitination and Activity of the Paracaspase MALT1 Requires Glutamate 549 in the Dimerization Interface

(2013) Katrin Cabalzar et al.   PLoS One

PSORS2 Is Due to Mutations in CARD14

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Role of ITAM signaling module in signal integration

(2012) Jelena S Bezbradica et al.   CURRENT OPINION IN IMMUNOLOGY

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

(2012) Anne Brüstle et al.   JOURNAL OF CLINICAL INVESTIGATION

A Two-Step Activation Mechanism of MALT1 Paracaspase

(2012) Jens Staal et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Determinants of MALT1 Protease Activity

(2012) Christian Wiesmann et al.   JOURNAL OF MOLECULAR BIOLOGY

T cell receptor/CARMA1/NF- B signaling controls T-helper (Th) 17 differentiation

(2012) L. L. Molinero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of T-Cell-Specific Nuclear Factor κB in Islet Allograft Rejection

(2012) Delia Lozano Porras et al.   TRANSPLANTATION

CARMA3 is Crucial for EGFR-Induced Activation of NF- B and Tumor Progression

(2011) T. Jiang et al.   CANCER RESEARCH

From MALT lymphoma to the CBM signalosome

(2011) Shaun Rosebeck et al.   CELL CYCLE

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma

(2011) R. A. Ramadas et al.   JOURNAL OF IMMUNOLOGY

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

(2011) Hiroshi I. Suzuki et al.   MOLECULAR CELL

Analysis of the coding genome of diffuse large B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE GENETICS

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region

(2011) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF- B Activation

(2011) S. Rosebeck et al.   SCIENCE

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

(2011) Sonja I. Gringhuis et al.   PLoS Pathogens

The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-dependent Vascular Inflammation and Atherogenesis

(2010) Linda M. McAllister-Lucas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin-dependent NF-κB Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3·Bcl10·MALT1 Signalosome

(2010) Phillip C. Delekta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

CXCL12/SDF‐1α Activates NF‐κB and Promotes Oral Cancer Invasion through the Carma3/Bcl10/Malt1 Complex

(2010) Aasia O Rehman et al.   International Journal of Oral Science

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Platelet-activating factor-induced NF-κB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent

(2009) Alip Borthakur et al.   INFLAMMATORY BOWEL DISEASES

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets

(2009) Michael W. Tusche et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

(2009) Uta Ferch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A20 Negatively Regulates T Cell Receptor Signaling to NF- B by Cleaving Malt1 Ubiquitin Chains

(2009) M. Duwel et al.   JOURNAL OF IMMUNOLOGY

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

(2009) Kazufumi Matsushita et al.   NATURE

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

(2009) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CARMA3 Mediates Lysophosphatidic Acid–Stimulated Cytokine Secretion by Bronchial Epithelial Cells

(2008) Benjamin D. Medoff et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF- B and MAPK activation to selectively control cytokine production

(2008) O. Gross et al.   BLOOD

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

The TREM-1/DAP12 pathway

(2008) Anja S. Tessarz et al.   IMMUNOLOGY LETTERS

CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex

(2008) Daniel Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF- B activation

(2008) C.-J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

(2008) G. Lenz et al.   SCIENCE