Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

Alphaherpesviral US3 Kinase Induces Cofilin Dephosphorylation To Reorganize the Actin Cytoskeleton

(2013) T. Jacob et al.   JOURNAL OF VIROLOGY

DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1

(2013) T. H. Pham et al.   JOURNAL OF VIROLOGY

Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

(2012) Václav Brázda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the small GTPase Rab27a during Herpes simplex virus infection of oligodendrocytic cells

(2012) Raquel Bello-Morales et al.   BMC MICROBIOLOGY

Endocytic tubules regulated by Rab GTPases 5 and 11 are used for envelopment of herpes simplex virus

(2012) Michael Hollinshead et al.   EMBO JOURNAL

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages

(2012) J. J. Miettinen et al.   JOURNAL OF VIROLOGY

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

(2012) T. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

(2012) Grazia Rosaria Gariano et al.   PLoS Pathogens

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Varicella-Zoster Virus Infection Triggers Formation of an Interleukin-1β (IL-1β)-processing Inflammasome Complex

(2011) Adel M. Nour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

(2011) Sudhakar Veeranki et al.   PLoS One

The Intrinsic Antiviral Defense to Incoming HSV-1 Genomes Includes Specific DNA Repair Proteins and Is Counteracted by the Viral Protein ICP0

(2011) Caroline E. Lilley et al.   PLoS Pathogens

The interferon-inducible HIN-200 gene family in apoptosis and inflammation: Implication for autoimmunity

(2010) Michele Mondini et al.   AUTOIMMUNITY

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein

(2010) I. M. Cristea et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus Immediate-Early ICP0 Protein Inhibits Toll-Like Receptor 2-Dependent Inflammatory Responses and NF-κB Signaling

(2010) Allison L. van Lint et al.   JOURNAL OF VIROLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

Myosin Va Enhances Secretion of Herpes Simplex Virus 1 Virions and Cell Surface Expression of Viral Glycoproteins

(2010) K. L. Roberts et al.   JOURNAL OF VIROLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

ICP0 Antagonizes ICP4-Dependent Silencing of the Herpes Simplex Virus ICP0 Gene

(2010) Mingyu Liu et al.   PLoS One

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Fungal pathogen recognition by the NLRP3 inflammasome

(2010) Sophie Joly et al.   Virulence

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

(2009) Jihan Akhtar et al.   FEBS Journal

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Oxidative damage to neurons caused by the induction of microglial NADPH oxidase in encephalomyocarditis virus infection

(2009) Yasuhisa Ano et al.   NEUROSCIENCE LETTERS

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

(2009) Julie Delaloye et al.   PLoS Pathogens

The microbial and danger signals that activate Nod-like receptors

(2008) Szilvia Benko et al.   CYTOKINE

Cellular Proteasome Activity Facilitates Herpes Simplex Virus Entry at a Postpenetration Step

(2008) M. G. Delboy et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus ICP0 Promotes both Histone Removal and Acetylation on Viral DNA during Lytic Infection

(2008) A. R. Cliffe et al.   JOURNAL OF VIROLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Hsc70 Focus Formation at the Periphery of HSV-1 Transcription Sites Requires ICP27

(2008) Ling Li et al.   PLoS One

Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling

(2008) Karen E. Johnson et al.   VIROLOGY

Silica binding and toxicity in alveolar macrophages

(2007) Raymond F. Hamilton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of IFI16 in DNA damage and checkpoint

(2007) Mutsuko Ouchi   Frontiers in Bioscience-Landmark

Interferon-inducible IFI16 protein in human cancers and autoimmune diseases

(2007) Divaker Choubey   Frontiers in Bioscience-Landmark