The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Manipulation of Interleukin-1β and Interleukin-18 Production byYersinia pestisEffectors YopJ and YopM and Redundant Impact on Virulence

(2016) Dmitry Ratner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of the innate immune response by the mevalonate pathway

(2016) Murali K Akula et al.   NATURE IMMUNOLOGY

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

(2016) Seth L. Masters et al.   Science Translational Medicine

Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever

(2016) Gayane Manukyan et al.   Frontiers in Microbiology

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

(2015) Man Lyang Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia

(2015) Daniel F. Aubert et al.   MICROBIOLOGY-SGM

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

(2015) Erin E. Zwack et al.   mBio

Identification of Mammalian Proteins That Collaborate with Type III Secretion System Function: Involvement of a Chemokine Receptor in Supporting Translocon Activity

(2015) Kerri-Lynn Sheahan et al.   mBio

Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function

(2014) M. G. Ghonime et al.   JOURNAL OF IMMUNOLOGY

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunological function of familial Mediterranean fever disease protein Pyrin

(2014) JieLing Yang et al.   Science China-Life Sciences

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

(2014) L. K. Chung et al.   mBio

The GAP Activity of Type III Effector YopE Triggers Killing of Yersinia in Macrophages

(2014) Xiaoying Wang et al.   PLoS Pathogens

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Regulation of the Yersinia type III secretion system: traffic control

(2013) Rebecca S. Dewoody et al.   Frontiers in Cellular and Infection Microbiology

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia

(2012) M. A. Gavrilin et al.   JOURNAL OF IMMUNOLOGY

YopK controls both rate and fidelity of Yop translocation

(2012) Rebecca Dewoody et al.   MOLECULAR MICROBIOLOGY

Burkholderia cenocepacia Type VI Secretion System Mediates Escape of Type II Secreted Proteins into the Cytoplasm of Infected Macrophages

(2012) Roberto Rosales-Reyes et al.   PLoS One

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

YopK regulates the Yersinia pestis type III secretion system from within host cells

(2011) Rebecca Dewoody et al.   MOLECULAR MICROBIOLOGY

Bacterial protein toxins that modify host regulatory GTPases

(2011) Klaus Aktories   NATURE REVIEWS MICROBIOLOGY

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

(2011) Ying Zheng et al.   PLoS Pathogens

Francisella Recognition by Inflammasomes: Differences between Mice and Men

(2011) Mikhail A. Gavrilin et al.   Frontiers in Microbiology

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages

(2010) Andrea J. McCoy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Delineation of Regions of the Yersinia YopM Protein Required for Interaction with the RSK1 and PRK2 Host Kinases and Their Requirement for Interleukin-10 Production and Virulence

(2010) J. B. McPhee et al.   INFECTION AND IMMUNITY

The C-Terminal Tail of Yersinia pseudotuberculosis YopM Is Critical for Interacting with RSK1 and for Virulence

(2010) M. W. McCoy et al.   INFECTION AND IMMUNITY

Yersinia Virulence Factor YopM Induces Sustained RSK Activation by Interfering with Dephosphorylation

(2010) Moritz Hentschke et al.   PLoS One

Yersinia outer protein YopE affects the actin cytoskeleton in Dictyostelium discoideum through targeting of multiple Rho family GTPases

(2009) Georgia Vlahou et al.   BMC MICROBIOLOGY

Pyrin Critical to Macrophage IL-1  Response to Francisella Challenge

(2009) M. A. Gavrilin et al.   JOURNAL OF IMMUNOLOGY