A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8

Cell death–mediated cytokine release and its therapeutic implications

(2019) David E. Place et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

(2019) Saskia D. Günther et al.   Nature Microbiology

Synthetic bottom-up approach reveals the complex interplay ofShigellaeffectors in regulation of epithelial cell death

(2018) Xiangyu Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors

(2018) Laurie Pinaud et al.   TRENDS IN MICROBIOLOGY

RIP kinases as modulators of inflammation and immunity

(2018) Sudan He et al.   NATURE IMMUNOLOGY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses

(2016) Mary K. Stewart et al.   NATURE REVIEWS MICROBIOLOGY

The Commonalities in Bacterial Effector Inhibition of Apoptosis

(2016) Keith S. Robinson et al.   TRENDS IN MICROBIOLOGY

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Necroptosis: The Trojan horse in cell autonomous antiviral host defense

(2015) Edward S. Mocarski et al.   VIROLOGY

Shigella Manipulates Host Immune Responses by Delivering Effector Proteins with Specific Roles

(2015) Hiroshi Ashida et al.   Frontiers in Immunology

Manipulation of the host cell death pathway byShigella

(2014) Hiroshi Ashida et al.   CELLULAR MICROBIOLOGY

The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection

(2013) Taira Kobayashi et al.   Cell Host & Microbe

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

EspO1-2 Regulates EspM2-Mediated RhoA Activity to Stabilize Formation of Focal Adhesions in Enterohemorrhagic Escherichia coli-Infected Host Cells

(2013) Tomoko Morita-Ishihara et al.   PLoS One

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

Calpain Activation by the Shigella flexneri Effector VirA Regulates Key Steps in the Formation and Life of the Bacterium's Epithelial Niche

(2012) Jean Bergounioux et al.   Cell Host & Microbe

Cell death and infection: A double-edged sword for host and pathogen survival

(2011) Hiroshi Ashida et al.   JOURNAL OF CELL BIOLOGY

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

A Soluble Form of the Pilus Protein FimA Targets the VDAC-Hexokinase Complex at Mitochondria to Suppress Host Cell Apoptosis

(2010) Sunil K. Sukumaran et al.   MOLECULAR CELL

Interactions between bacterial pathogens and mitochondrial cell death pathways

(2010) Thomas Rudel et al.   NATURE REVIEWS MICROBIOLOGY

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

(2010) C. Hemrajani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

(2009) Nicolas Dupont et al.   Cell Host & Microbe

Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells

(2009) Leticia A.M. Carneiro et al.   Cell Host & Microbe

Spa15 of Shigella flexneri Is Secreted through the Type III Secretion System and Prevents Staurosporine-Induced Apoptosis

(2009) C. S. Faherty et al.   INFECTION AND IMMUNITY

Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment

(2009) Minsoo Kim et al.   NATURE

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade

(2008) Rheinallt M. Jones et al.   Cell Host & Microbe