IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

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Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

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Interferon Regulatory Factor 1 Protects against Chikungunya Virus-Induced Immunopathology by Restricting Infection in Muscle Cells

(2017) Sharmila Nair et al.   JOURNAL OF VIROLOGY

Regulation and functions of NLRP3 inflammasome during influenza virus infection

(2017) Teneema Kuriakose et al.   MOLECULAR IMMUNOLOGY

The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection

(2017) Bibhabasu Hazra et al.   Science Signaling

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection

(2017) Bibhabasu Hazra et al.   Science Signaling

Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

(2017) Jun Yang et al.   Nature Microbiology

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

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Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

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The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production

(2014) April Kalinowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival

(2014) Ian Gaël Rodrigue-Gervais et al.   Cell Host & Microbe

Tick-Borne Flaviviruses Antagonize Both IRF-1 and Type I IFN Signaling To Inhibit Dendritic Cell Function

(2014) S. J. Robertson et al.   JOURNAL OF IMMUNOLOGY

Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells

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Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

(2014) Sharmila Nair et al.   PLoS Pathogens

Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels

(2013) Catherine J. Sanders et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

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Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium

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Interferon Regulatory Factor 1 Polymorphisms Previously Associated with Reduced HIV Susceptibility Have No Effect on HIV Disease Progression

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Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Interferon Regulatory Factor-1 (IRF-1) Shapes Both Innate and CD8+ T Cell Immune Responses against West Nile Virus Infection

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DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

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Inflammasome recognition of influenza virus is essential for adaptive immune responses

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The Pathology of Influenza Virus Infections

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

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