Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Control of the innate immune response by the mevalonate pathway

(2016) Murali K Akula et al.   NATURE IMMUNOLOGY

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

(2016) Hanne Van Gorp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

(2016) Seth L. Masters et al.   Science Translational Medicine

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers

(2015) Silvia Federici et al.   ANNALS OF THE RHEUMATIC DISEASES

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

(2015) Man Lyang Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Ex vivo PBMC cytokine profile in familial Mediterranean fever patients: Involvement of IL-1β, IL-1α and Th17-associated cytokines and decrease of Th1 and Th2 cytokines

(2014) José-Noel Ibrahim et al.   CYTOKINE

Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever

(2014) Pinar Cetin et al.   INFLAMMATION

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Rilonacept for Colchicine-Resistant or -Intolerant Familial Mediterranean Fever

(2013) Philip J. Hashkes et al.   ANNALS OF INTERNAL MEDICINE

Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation withMEFVgenotype

(2013) Alessia Omenetti et al.   ANNALS OF THE RHEUMATIC DISEASES

Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activatesin Vitrothe Human Pyrin Inflammasome

(2013) Je-Wook Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Risk of Familial Mediterranean Fever in MEFV Heterozygotes: A Statistical Approach

(2013) Isabelle Jéru et al.   PLoS One

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical impact ofMEFVmutations in children with periodic fever in a prevalent western European Caucasian population

(2012) Silvia Federici et al.   ANNALS OF THE RHEUMATIC DISEASES

Guidelines for the genetic diagnosis of hereditary recurrent fevers

(2012) Y Shinar et al.   ANNALS OF THE RHEUMATIC DISEASES

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens

(2009) Igor E. Brodsky et al.   SEMINARS IN IMMUNOLOGY

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA