Human NLRP1 is a sensor for double-stranded RNA

CARD8 inflammasome activation triggers pyroptosis in human T cells

(2020) Andreas Linder et al.   EMBO JOURNAL

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

(2020) Kim S. Robinson et al.   SCIENCE

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

(2019) Scott B. Drutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

(2019) Kuo Gai et al.   Cell Death & Disease

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

(2019) Patrick S Mitchell et al.   CURRENT OPINION IN IMMUNOLOGY

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

(2018) Jingtao Lilue et al.   NATURE GENETICS

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

(2018) Franklin L. Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

(2016) Franklin L. Zhong et al.   CELL

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

(2016) Joseph Chavarría-Smith et al.   PLoS Pathogens

High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome

(2015) Philip A. Harris et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Establishing the role of ATP for the function of the RIG-I innate immune sensor

(2015) David C Rawling et al.   eLife

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Trans genomic capture and sequencing of primate exomes reveals new targets of positive selection

(2011) R. D. George et al.   GENOME RESEARCH

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY