Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

(2017) Mark A Wacker et al.   Innate Immunity

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

(2017) Eric M. Feeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia

(2016) Sivakumar Periasamy et al.   PLoS Pathogens

Interferon-inducible GTPases in cell autonomous and innate immunity

(2015) Etienne Meunier et al.   CELLULAR MICROBIOLOGY

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages

(2015) Ryan Finethy et al.   INFECTION AND IMMUNITY

cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection

(2015) Kelly M. Storek et al.   JOURNAL OF IMMUNOLOGY

Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity

(2015) Flaviana Di Lorenzo et al.   MOLECULAR IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

A Critical Role for Human Caspase-4 in Endotoxin Sensitivity

(2014) Y. Kajiwara et al.   JOURNAL OF IMMUNOLOGY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Human NLRP3 inflammasome senses multiple types of bacterial RNAs

(2014) Wenwen Sha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response

(2014) Ting Liu et al.   Cell Reports

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells

(2011) Kamila Belhocine et al.   CELLULAR MICROBIOLOGY

Francisella tularensisReveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation

(2011) Maninjay K. Atianand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

(2010) Jianghong Wu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling

(2010) Jeanette E. Bröms et al.   Frontiers in Microbiology

Listeria monocytogenes-Infected Human Peripheral Blood Mononuclear Cells Produce IL-1 , Depending on Listeriolysin O and NLRP3

(2009) K. Meixenberger et al.   JOURNAL OF IMMUNOLOGY

Pyrin Critical to Macrophage IL-1  Response to Francisella Challenge

(2009) M. A. Gavrilin et al.   JOURNAL OF IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies

(2008) Alexandra Kresse et al.   BMC GENOMICS