Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

(2020) Valentina C. Sladky et al.   DEVELOPMENTAL CELL

TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating

(2020) Hao Yan et al.   Nature Communications

A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest

(2020) Michael Tsabar et al.   Cell Reports

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

(2019) Mathew Bowler et al.   Nature Communications

Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability

(2019) Jiajia Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

(2019) Claudia Contadini et al.   Cell Death & Disease

Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis

(2018) Carla A.M. Lopes et al.   JOURNAL OF CELL BIOLOGY

Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components

(2018) T. Tony Yang et al.   Nature Communications

Who are you, subdistal appendages of centriole?

(2018) Rustem Uzbekov et al.   Open Biology

Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

(2018) Teresa Arnandis et al.   DEVELOPMENTAL CELL

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

(2017) Kiyohiro Ando et al.   JOURNAL OF CELL BIOLOGY

The resurrection of the PIDDosome – emerging roles in the DNA-damage response and centrosome surveillance

(2017) Valentina Sladky et al.   JOURNAL OF CELL SCIENCE

DiAna, an ImageJ tool for object-based 3D co-localization and distance analysis

(2017) Jean-François Gilles et al.   METHODS

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia

(2016) Gregory Mazo et al.   DEVELOPMENTAL CELL

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

(2016) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

(2016) Franz Meitinger et al.   JOURNAL OF CELL BIOLOGY

The Centrosome, a Multitalented Renaissance Organelle

(2016) Anastassiia Vertii et al.   Cold Spring Harbor Perspectives in Biology

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

(2016) Chii Shyang Fong et al.   eLife

Centrosomes in the DNA damage response—the hub outside the centre

(2015) Lisa I. Mullee et al.   CHROMOSOME RESEARCH

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

Flexible Stoichiometry and Asymmetry of the PIDDosome Core Complex by Heteronuclear NMR Spectroscopy and Mass Spectrometry

(2015) Lily A. Nematollahi et al.   JOURNAL OF MOLECULAR BIOLOGY

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

The Centrosomal Linker and Microtubules Provide Dual Levels of Spatial Coordination of Centrosomes

(2015) Marko Panic et al.   PLoS Genetics

Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles

(2014) Dong Kong et al.   JOURNAL OF CELL BIOLOGY

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation

(2014) Dominique Bluteau et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centriole distal appendages promote membrane docking, leading to cilia initiation

(2013) B. E. Tanos et al.   GENES & DEVELOPMENT

Primary ciliogenesis requires the distal appendage component Cep123

(2013) J. E. Sillibourne et al.   Biology Open

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast

(2012) Agnes Grallert et al.   NATURE CELL BIOLOGY

Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families

(2011) P. Noris et al.   BLOOD

The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade

(2011) L X Heinz et al.   CELL DEATH AND DIFFERENTIATION

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

(2011) Lis Jakobsen et al.   EMBO JOURNAL

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly

(2010) Moe R. Mahjoub et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

A one-step SYBR Green I-based product-enhanced reverse transcriptase assay for the quantitation of retroviruses in cell culture supernatants

(2008) Massimo Pizzato et al.   JOURNAL OF VIROLOGICAL METHODS