The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke

Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential

(2021) Evandro Manoel Neto-Neves et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review

(2021) Jéssica Silva dos Santos et al.   Frontiers in Pharmacology

MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway

(2020) Shuhuan Song et al.   NEUROCHEMICAL RESEARCH

Glial Cells: Role of the Immune Response in Ischemic Stroke

(2020) Shenbin Xu et al.   Frontiers in Immunology

Effect of Luteolin and Apigenin on the Production of Il-31 and Il-33 in Lipopolysaccharides-Activated Microglia Cells and Their Mechanism of Action

(2020) Denis Nchang Che et al.   Nutrients

The Presence of Caffeic Acid in Cerebrospinal Fluid: Evidence That Dietary Polyphenols Can Cross the Blood-Brain Barrier in Humans

(2020) Izabela Grabska-Kobylecka et al.   Nutrients

Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway

(2020) Yu Yuan et al.   INFLAMMOPHARMACOLOGY

Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage

(2020) Yi Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice

(2020) Shiquan Wang et al.   Frontiers in Aging Neuroscience

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke

(2020) Kaibin Shi et al.   CIRCULATION RESEARCH

Anthocyanin ameliorates hypoxia and ischemia induced inflammation and apoptosis by increasing autophagic flux in SH-SY5Y cells

(2020) Yiyu Cai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation

(2020) Kai Le et al.   INFLAMMATION RESEARCH

Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway

(2020) Shuwen Liu et al.   NEUROCHEMICAL RESEARCH

Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain

(2020) Rahat Ullah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia

(2020) Mariana Mota et al.   Journal of Neuroinflammation

Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review

(2020) Yuan Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nano-curcumin simultaneously protects the blood-brain barrier and reduces M1-microglial activation during cerebral ischemia-reperfusion injury

(2019) Ye Wang et al.   ACS Applied Materials & Interfaces

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

Silymarin, a polyphenolic flavonoid impede Plasmodium falciparum growth through interaction with heme

(2019) Pooja Rani Mina et al.   NATURAL PRODUCT RESEARCH

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

(2019) Tahir Muhammad et al.   Nutrients

Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis

(2019) Wa Cai et al.   AGEING RESEARCH REVIEWS

Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization

(2019) Chuwen Li et al.   ACS Chemical Neuroscience

Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF‐α–induced injury via inhibiting NF‐κB and JNK signals

(2019) Lei Tian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke

(2019) Xi Zhang et al.   Journal of Neuroinflammation

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

(2019) Li-Ting Guo et al.   Journal of Neuroinflammation

Brain oxidative damage in murine models of neonatal hypoxia/ischemia and reoxygenation

(2019) Isabel Torres-Cuevas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

(2019) Diogo Carregosa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

(2019) Morena Zusso et al.   Journal of Neuroinflammation

Neuroprotective effect of chlorogenic acid in global cerebral ischemia-reperfusion rat model

(2019) Gaurav Kumar et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Polyphenols: A concise overview on the chemistry, occurrence, and human health

(2019) Alessandra Durazzo et al.   PHYTOTHERAPY RESEARCH

Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage

(2019) Shilun Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats

(2019) Wei-Han Li et al.   BRAIN RESEARCH

Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

(2019) Zhen Tang et al.   EXPERIMENTAL NEUROLOGY

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

(2019) Gunnar R. Leitner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Caffeic acid reduces oxidative stress and microglial activation in the mouse hippocampus

(2019) Minori Koga et al.   TISSUE & CELL

Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts

(2019) Jing Xue et al.   Journal of the American Heart Association

Resveratrol promoted the M2 polarization of microglia and reduced neuroinflammation after cerebral ischemia by inhibiting miR-155

(2019) Shan Ma et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

(2019) Ming-Shun Wu et al.   MOLECULES

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism

(2018) Dongpei Yin et al.   BRAIN RESEARCH

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

(2018) Yunyi Dai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway

(2018) Xiao Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model

(2018) Dong-Ju PARK et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury

(2018) Chengli Ling et al.   MOLECULES

Epidemiology, aetiology, and management of ischaemic stroke in young adults

(2018) Merel S Ekker et al.   LANCET NEUROLOGY

Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: Neuroprotective role of vanillic acid

(2018) Seyed Esmaeil Khoshnam et al.   LIFE SCIENCES

Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus

(2018) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-κB and NLRP3 Pathways

(2018) Hong-Xin Cui et al.   MOLECULES

The natural phenolic compounds as modulators of NADPH oxidases in hypertension

(2018) Mozhdeh Yousefian et al.   PHYTOMEDICINE

Angioedema and Hemorrhage After 4.5-Hour tPA (Tissue-Type Plasminogen Activator) Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity

(2018) Qing-Fang Chen et al.   STROKE

Post-stroke inflammation—target or tool for therapy?

(2018) Kate Lykke Lambertsen et al.   ACTA NEUROPATHOLOGICA

Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-κB Phosphorylation

(2018) Chien-Chung Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effects and mechanism of curcumin on myocardial injury induced by coronary microembolization

(2018) Yang Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells

(2018) Kecheng Zhou et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Dietary Lignans: Definition, Description and Research Trends in Databases Development

(2018) Alessandra Durazzo et al.   MOLECULES

Quercetin Might Promote Autophagy in a Middle Cerebral Artery Occlusion-Mediated Ischemia Model: Comments on Fawad-Ali Shah et al.

(2018) Salvatore Chirumbolo et al.   NEUROCHEMICAL RESEARCH

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

(2018) Nour Yahfoufi et al.   Nutrients

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

(2018) Michał Wiciński et al.   Nutrients

Protective Effect of Anthocyanin on Neurovascular Unit in Cerebral Ischemia/Reperfusion Injury in Rats

(2018) Zihao Pan et al.   Frontiers in Neuroscience

The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature

(2017) Narges Tajik et al.   EUROPEAN JOURNAL OF NUTRITION

Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo

(2017) Zhongkun Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke

(2017) Chih-Hao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

(2017) Lifa Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis

(2017) Marta Pulido-Salgado et al.   Journal of Neuroinflammation

Orientin Attenuates Cerebral Ischemia/Reperfusion Injury in Rat Model through the AQP-4 and TLR4/NF-κB/TNF-α Signaling Pathway

(2017) Xiaoru Wang et al.   Journal of Stroke & Cerebrovascular Diseases

Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats

(2017) Adel Abdel-Moneim et al.   METABOLIC BRAIN DISEASE

Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-κB, ICAM-1, MMP-9 and caspase-3 expression

(2017) Wei Li et al.   Molecular Medicine Reports

Neuroprotective diets for stroke

(2017) María Irene Ayuso et al.   NEUROCHEMISTRY INTERNATIONAL

The Impact of Coffee on Health

(2017) Karen Nieber   PLANTA MEDICA

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

(2017) Bo Li et al.   PROGRESS IN NEUROBIOLOGY

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke

(2017) Alicia García-Culebras et al.   STROKE

A comprehensive review of the health perspectives of resveratrol

(2017) Abdur Rauf et al.   Food & Function

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

(2017) Zongjian Liu et al.   Frontiers in Aging Neuroscience

Orientin Attenuates Cerebral Ischemia/Reperfusion Injury in Rat Model through the AQP-4 and TLR4/NF-κB/TNF-α Signaling Pathway

(2017) Xiaoru Wang et al.   Journal of Stroke & Cerebrovascular Diseases

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

(2017) Wei Liang et al.   Aging and Disease

Polyphenols journey through blood-brain barrier towards neuronal protection

(2017) I. Figueira et al.   Scientific Reports

Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

(2016) Natarajan Suganthy et al.   BIOMEDICINE & PHARMACOTHERAPY

Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice

(2016) Mei-Yin Chien et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion

(2016) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

(2016) Anuradha Kalani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R

(2016) Wei Li et al.   MICROVASCULAR RESEARCH

Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats

(2016) Cai-Ping Wang et al.   MOLECULAR NEUROBIOLOGY

Silibinin rescues learning and memory deficits by attenuating microglia activation and preventing neuroinflammatory reactions in SAMP8 mice

(2016) Ge Jin et al.   NEUROSCIENCE LETTERS

HSP60 mediates the neuroprotective effects of curcumin by suppressing microglial activation

(2016) Feijia Ding et al.   Experimental and Therapeutic Medicine

Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction

(2016) Chuan Li et al.   Redox Biology

The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats

(2015) Guojuan Liang et al.   Behavioral and Brain Functions

Health benefits of anthocyanins and molecular mechanisms: Update from recent decade

(2015) Daotong Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Curcumin, an active component of turmeric (Curcuma longa), and its effects on health

(2015) Betül Kocaadam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Genistein: A Boon for Mitigating Ischemic Stroke

(2015) Seyed Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia-ischemia

(2015) Takashi Umekawa et al.   GLIA

The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals

(2015) Libing Ye et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation

(2015) Wenlu Li et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of BV-2 microglia functions by novel quercetin pivaloyl ester

(2015) Nataša Mrvová et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol neuroprotection in stroke and traumatic CNS injury

(2015) Mary S. Lopez et al.   NEUROCHEMISTRY INTERNATIONAL

Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway

(2015) Yisong Qian et al.   PHARMACEUTICAL BIOLOGY

Kaempferol and inflammation: From chemistry to medicine

(2015) Kasi Pandima Devi et al.   PHARMACOLOGICAL RESEARCH

Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism

(2015) Ilaria Zanotti et al.   Food & Function

Estimated Daily Intake and Seasonal Food Sources of Quercetin in Japan

(2015) Haruno Nishimuro et al.   Nutrients

Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man

(2015) Carlo Caltagirone et al.   Translational Stroke Research

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats

(2015) Olatz Arteaga et al.   PLoS One

Coffee consumption and risk of fractures: A systematic review and dose–response meta-analysis

(2014) Dong Ryul Lee et al.   BONE

Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia

(2014) Jin-Woo Jeong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Kaempferol, a potential cytostatic and cure for inflammatory disorders

(2014) Peramaiyan Rajendran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Redox regulation of NF-κB p50 and M1 polarization in microglia

(2014) Thomas Taetzsch et al.   GLIA

Curcumin Inhibits TLR2/4-NF-κB Signaling Pathway and Attenuates Brain Damage in Permanent Focal Cerebral Ischemia in Rats

(2014) Xian-kun Tu et al.   INFLAMMATION

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

(2014) Darrell Sawmiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Flavan-3-ols, anthocyanins, and inflammation

(2014) Pedro Mena et al.   IUBMB LIFE

Pharmacokinetics, brain distribution, release and blood–brain barrier transport of Shunaoxin pills

(2014) Kai Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-κB pathway

(2014) TAO HUANG et al.   Molecular Medicine Reports

Protective Effect of Naringenin in Experimental Ischemic Stroke: Down-Regulated NOD2, RIP2, NF-κB, MMP-9 and Up-Regulated Claudin-5 Expression

(2014) Xue Bai et al.   NEUROCHEMICAL RESEARCH

Ferulic acid attenuates the cerebral ischemic injury-induced decrease in peroxiredoxin-2 and thioredoxin expression

(2014) Jin-Hee Sung et al.   NEUROSCIENCE LETTERS

Neuroprotective effect of pAkt and HIF-1 α on ischemia rats

(2014) Bao-Nan Liu et al.   Asian Pacific Journal of Tropical Medicine

Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression

(2013) Jian Zhang et al.   BRAIN RESEARCH

Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition

(2013) Nan Wang et al.   NEUROPHARMACOLOGY

Neuroprotective Role of Nanoencapsulated Quercetin in Combating Ischemia-Reperfusion Induced Neuronal Damage in Young and Aged Rats

(2013) Aparajita Ghosh et al.   PLoS One

Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages

(2013) Akari Ishisaka et al.   PLoS One

Ferulic acid prevents cerebral ischemic injury-induced reduction of hippocalcin expression

(2013) Phil-Ok Koh   SYNAPSE

Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content

(2013) J. A. Rothwell et al.   Database-The Journal of Biological Databases and Curation

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

(2013) Carlo Perego et al.   Jove-Journal of Visualized Experiments

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Green tea polyphenol epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa laminin receptor on lipopolysaccharide-stimulated dendritic cells

(2012) Eui-Baek Byun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia

(2012) Huimin Qiao et al.   BRAIN RESEARCH

Hormone therapy and the risk of stroke: perspectives 10 years after the Women's Health Initiative trials

(2012) V. W. Henderson et al.   CLIMACTERIC

Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway

(2012) CUI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Curcumin reduces the cardiac ischemia–reperfusion injury: involvement of the toll-like receptor 2 in cardiomyocytes

(2012) Yong Sook Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [11C]vinpocetine

(2012) Balázs Gulyás et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment

(2012) A. Csiszar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

(2012) Annamaria Lanzillotta et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model

(2012) Yisong Qian et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke

(2012) S.S. Raza et al.   NEUROSCIENCE

Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression

(2012) Chaohui Wang et al.   NEUROSCIENCE LETTERS

Dietary Flavonoids and Risk of Stroke in Women

(2012) Aedín Cassidy et al.   STROKE

Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage

(2011) Lauren H. Sansing et al.   ANNALS OF NEUROLOGY

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Monocyclic Phenolic Acids; Hydroxy- and Polyhydroxybenzoic Acids: Occurrence and Recent Bioactivity Studies

(2011) Shahriar Khadem et al.   MOLECULES

NF-κB and innate immunity in ischemic stroke

(2010) Olivier A. Harari et al.   Annals of the New York Academy of Sciences

Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation

(2010) Xia Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Extraction and Analysis of Polyphenols: Recent trends

(2010) C.M. Ajila et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats

(2010) Mei Gao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

(2010) Jin A. Shin et al.   JOURNAL OF NEUROIMMUNOLOGY

Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism

(2010) Hyun-Ja Jeong et al.   Journal of Neuroinflammation

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

(2010) Konstantin Dirscherl et al.   Journal of Neuroinflammation

Spatio-Temporal Distribution of Inflammatory Reaction and Expression of TLR2/4 Signaling Pathway in Rat Brain Following Permanent Focal Cerebral Ischemia

(2010) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

Preventive effect of silymarin in cerebral ischemia–reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation

(2010) Yu-Chang Hou et al.   PHYTOMEDICINE

Flavonoids as anti-inflammatory agents

(2010) Mauro Serafini et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Improved characterization of tomato polyphenols using liquid chromatography/electrospray ionization linear ion trap quadrupole Orbitrap mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry

(2010) Anna Vallverdú-Queralt et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor- B and Signal Transducers and Activators of Transcription 3

(2009) A. Tyagi et al.   Cancer Prevention Research

Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

(2009) Dobroslawa Bialonska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ferulic Acid Reduces Cerebral Infarct Through Its Antioxidative and Anti-Inflammatory Effects Following Transient Focal Cerebral Ischemia in Rats

(2008) Chin-Yi Cheng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Anti-ischemic Effect of Curcumin in Rat Brain

(2008) Pradeep K. Shukla et al.   NEUROCHEMICAL RESEARCH