Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke

Inhibition of proinflammatory mediators by coumaroyl lupendioic acid, a new lupane-type triterpene from Careya arborea , on inflammation-induced animal model

(2017) Rayhana Begum et al.   JOURNAL OF ETHNOPHARMACOLOGY

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

(2017) Chun-Chun Wei et al.   Scientific Reports

Resveratrol pretreatment attenuates injury and promotes proliferation of neural stem cells following oxygen-glucose deprivation/reoxygenation by upregulating the expression of Nrf2, HO-1 and NQO1 in vitro

(2016) Changbo Shen et al.   Molecular Medicine Reports

Andrographolide stimulates p38 mitogen-activated protein kinase–nuclear factor erythroid-2-related factor 2–heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats

(2016) Ting-Lin Yen et al.   Translational Research

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress

(2014) Yi-Lin Cheng et al.   BRAIN RESEARCH

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

(2014) Yi Ding et al.   MOLECULAR NEUROBIOLOGY

Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway

(2014) Yongliang Huang et al.   Oxidative Medicine and Cellular Longevity

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

(2014) Yu-Ying Chen et al.   Scientific Reports

Andrographolide, a Novel NF-κB Inhibitor, Induces Vascular Smooth Muscle Cell Apoptosis via a Ceramide-p47phox-ROS Signaling Cascade

(2013) Yu-Ying Chen et al.   Evidence-based Complementary and Alternative Medicine

ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

(2013) Amadeus Gladbach et al.   JOURNAL OF NEURAL TRANSMISSION

A novel bioactivity of andrographolide fromAndrographis paniculataon cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis

(2013) Ting-Lin Yen et al.   PHARMACEUTICAL BIOLOGY

Mechanisms of Andrographolide-Induced Platelet Apoptosis in Human Platelets: Regulatory Roles of the Extrinsic Apoptotic Pathway

(2013) Li-Ming Lien et al.   PHYTOTHERAPY RESEARCH

Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway

(2013) Kai Wu et al.   PLANTA MEDICA

Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB

(2013) Tao Zhu et al.   PLoS One

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

(2012) Aurelie Nguyen Dinh Cat et al.   ANTIOXIDANTS & REDOX SIGNALING

Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: Regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade

(2012) Wan J. Lu et al.   BIOCHEMICAL PHARMACOLOGY

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

ERK5: Structure, regulation and function

(2012) Gopika N. Nithianandarajah-Jones et al.   CELLULAR SIGNALLING

Targeting Heme Oxygenase-1 in Vascular Disease

(2012) William Durante   CURRENT DRUG TARGETS

Vascular Smooth Muscle Cell Proliferation in Restenosis

(2011) Steven O. Marx et al.   Circulation-Cardiovascular Interventions

The role of free radical generation in increasing cerebrovascular permeability

(2011) Paul A. Fraser   FREE RADICAL BIOLOGY AND MEDICINE

A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP

(2011) Wan-Jung Lu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat

(2011) Aida Maddahi et al.   Journal of Neuroinflammation

Andrographolide Inhibits PI3K/AKT-Dependent NOX2 and iNOS Expression Protecting Mice against Hypoxia/Ischemia-Induced Oxidative Brain Injury

(2011) Chang-Ming Chern et al.   PLANTA MEDICA

Heme Oxygenase in the Regulation of Vascular Biology: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Young-Myeong Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia

(2010) Su Jing Chan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Andrographolide Enhances Nuclear Factor-κB Subunit p65 Ser536Dephosphorylation through Activation of Protein Phosphatase 2A in Vascular Smooth Muscle Cells

(2010) Cheng Y. Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral ischemia induces micro vascular pro-inflammatory cytokine expression via the MEK/ERK pathway

(2010) Aida Maddahi et al.   Journal of Neuroinflammation

Brain Endothelial Cell Death: Modes, Signaling Pathways, and Relevance to Neural Development, Homeostasis, and Disease

(2010) Maria Teresa Rizzo et al.   MOLECULAR NEUROBIOLOGY

A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway

(2009) Zhang Bao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exercise and the brain: something to chew on

(2009) Henriette van Praag   TRENDS IN NEUROSCIENCES

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

(2008) G. Stoll et al.   BLOOD

In vitro and in vivo anti-inflammatory effects of andrographolide

(2008) Ala'a A. Abu-Ghefreh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Miyabenol A Inhibits LPS-Induced NO Production via IKK/IκB Inactivation in RAW 264.7 Macrophages: Possible Involvement of the p38 and PI3K Pathways

(2008) Kuei-Ting Ku et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-Inflammatory Effects of Sinapic Acid through the Suppression of Inducible Nitric Oxide Synthase, Cyclooxygase-2, and Proinflammatory Cytokines Expressions via Nuclear Factor-κB Inactivation

(2008) Kyung-Jin Yun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

NF-κB Transcription Factor p50 Critically Regulates Tissue Factor in Deep Vein Thrombosis

(2008) Yi-Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

(2008) Alexander Sarlette et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly

(2007) A R Green   BRITISH JOURNAL OF PHARMACOLOGY