Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Summary: Nitric oxide (NO) is a small molecule that has a significant impact on various biological activities. It has been linked to cancer-related processes and has the potential to be used as an anti-cancer agent. In this study, NO-releasing materials were developed using modified sodium alginate hydrogel, which showed compatibility with cell growth. The release of NO from the hydrogel exhibited distinct kinetic features.
Article
Environmental Sciences
Dalia H. El-Kashef, Maha H. Sharawy
Summary: Nicorandil protects against acetaminophen-induced liver damage by reducing liver function indicators, inhibiting oxidative stress and inflammation, and improving cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Agnieszka Zablocka, Dominika Jakubczyk, Katarzyna Leszczynska, Katarzyna Pacyga-Prus, Jozefa Macala, Sabina Gorska
Summary: This study investigated the ability of Bifidobacterium species to induce iNOS-dependent NO synthesis in macrophages. The results showed that Bifidobacterium can regulate the expression of iNOS and produce NO by activating MAPK kinases. TLR2 and TLR4 receptors are involved in Bifidobacterium-induced macrophage activation and NO production. The study suggests that Bifidobacterium has a protective mechanism in the intestine, and its efficacy is strain-dependent.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Tetsuya Tachibana, Maki Takahashi, Sakirul Khan, Ryosuke Makino, Mark A. Cline
Summary: This study aimed to investigate the effects of virus component analogues on NO production in chicks and found that poly I:C and R848 significantly increased plasma NO concentrations and induced an increase in iNOS mRNA expression. The study also found that these virus analogues decreased mRNA expressions of endothelial NOS and neural NOS in several organs, suggesting that iNOS might be responsible for the increased plasma NO levels. These findings suggest that viral infections facilitate NO production by inducing iNOS and are associated with corticosterone release in birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chang-Ho Kang, Jin-Seong Kim, Hyemin Kim, Hye Min Park, Nam-Soo Paek
Summary: The study found that heat-killed lactic acid bacteria have immunomodulatory functions and antioxidant activity, making them suitable for use as probiotics. Heat treatment of strains can prolong the shelf-life of probiotic foods and significantly inhibit the expression of nitric oxide synthase and cyclooxygenase-2.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Corina Daniela Ene, Ilinca Nicolae
Summary: This study explores the relationship between NOS2-associated inflammation profiles and SLE phenotypes. The variations in biomarkers are strongly associated with the decrease in eGFR and increase in albuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ricardo Carnicer, Drew Duglan, Klemen Ziberna, Alice Recalde, Svetlana Reilly, Jillian N. Simon, Simona Mafrici, Ritu Arya, Esther Rosello-Lleti, Surawee Chuaiphichai, Damian Tyler, Craig A. Lygate, Keith M. Channon, Barbara Casadei
Summary: Myocardial BH4 was found to prevent and reverse left ventricular diastolic and systolic dysfunction associated with diabetes by increasing insulin-independent myocardial glucose uptake and utilization. This mechanism highlights the potential for GCH1/BH4-based therapeutics in human diabetic cardiomyopathy.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Robert J. Webber, Richard M. Sweet, Douglas S. Webber
Summary: The study found that anti-MV-A iNOS monoclonal antibodies can mitigate the harmful effects of MV-A iNOS and increase the survival rate of mice challenged with sepsis. The efficacy of the treatment is both time- and dose-dependent. Humanized anti-MV-A iNOS mAbs could potentially save tens of thousands of lives annually and improve antibiotic stewardship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Amelia Cataldi, Rosa Amoroso, Viviana di Giacomo, Susi Zara, Cristina Maccallini, Marialucia Gallorini
Summary: Nitric oxide plays a key role in physiological and pathological processes in mammals, and excessive production is associated with inflammation. Dental pulp inflammation caused by pathogenic bacteria may affect the functions of dental pulp stem cells. Inhibiting nitric oxide production could be a new strategy for treating inflammation and promoting the regeneration of the dentin-pulp complex. This study evaluated two acetamidines related to a selective inhibitor of nitric oxide, and the results showed that they have potential as anti-inflammatory compounds while retaining the mineralization and angiogenic potential of cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Ki Hyun Kim
Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: Treating brainstem cavernous malformations with microsurgery or radiosurgery has shown to be effective in reducing the rehemorrhage rate. The neurosurgery cohort had lower incidence of symptomatic intracranial hemorrhage, while the radiosurgery cohort had lower incidence of persistent focal neurological deficit.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Xiang-Yu Gao, Jian Zang, Min-Hua Zheng, Yu-Fei Zhang, Kang-Yi Yue, Xiu-Li Cao, Yuan Cao, Xin-Xin Li, Hua Han, Xiao-Fan Jiang, Liang Liang
Summary: Glioma stem cells formation is promoted by TMZ treatment through upregulation of HMGB1, which activates the TLR2/NEAT1/Wnt pathway, providing a potential therapeutic target for preventing TMZ resistance in GBM patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qingdong Guo, Jun Guo, Wei Liu, Shijie Hu, Xuean Hu, Qianliang Wang, Xiaofan Jiang
Summary: This study identified the novel circRNA circ-EGFR as a regulator in glioma progression by modulating the levels of miR-183-5p and TUSC2. Circ-EGFR acted as a sponge for miR-183-5p and hindered glioma development. Targeting the miR-183-5p/TUSC2 axis, circ-EGFR showed potential as a therapeutic target for glioma progression.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Chao Lv, Yan-Wei Chen, Shu-Hui Dai, Xiao-Fan Jiang, Xia Li
Summary: This study developed a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) for the treatment of cerebral ischemia-reperfusion injury, showing potential efficacy in vitro experiments.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Clinical Neurology
Yuefei Zhou, Yue Hei, Jose M. Soto, Tao Jin, Xiaofan Jiang, Dongxia Feng, Weiping Liu, Dakuan Gao
Summary: The study aimed to analyze the efficacy of multilayered skull base reconstruction using in situ bone flap for craniopharyngiomas. Patients undergoing this reconstruction had significantly lower rates of lumbar drainage and CSF leakage, and also experienced reduced nasal exudation, bed rest time, and hospitalization.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Cell Biology
Yutao Huang, Xiangyu Gao, Erwan Yang, Kangyi Yue, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: With the shift from the histology epoch to the molecular era in malignant glioma research, there is a growing need to investigate diagnostic/prognostic/therapeutic biomarkers and their regulatory mechanisms. This study identified differentially expressed genes and ceRNA networks in malignant glioma and constructed predictive models. The results revealed correlations between these genes and circadian rhythm, tumor immune microenvironment, and cellular senescence pathways. These findings provide new insights for precise diagnosis and personalized treatment of malignant glioma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yutao Huang, Haofuzi Zhang, Erwan Yang, Kangyi Yue, Xiangyu Gao, Shuhui Dai, Jialiang Wei, Yuefan Yang, Peng Luo, Xin Li, Xiaofan Jiang
Summary: In this study, differentially expressed proteins (DEPs) and differentially expressed phosphoproteins (DEPPs) in the early and late stages of TBI were identified using TMT labeling, Phos affinity enrichment, and high-resolution LC-MS/MS analysis. Integrative analyses revealed the different and similar pathophysiologic mechanisms between the early and late stages, providing insights into useful biomarkers and underlying mechanisms in TBI and its sequelae.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Immunology
Shuhui Dai, Jialiang Wei, Hongchen Zhang, Peng Luo, Yuefan Yang, Xiaofan Jiang, Zhou Fei, Wenbin Liang, Jianli Jiang, Xia Li
Summary: Intermittent fasting (IF) protects against intracerebral hemorrhage (ICH) by suppressing inflammatory responses and cellular injuries through the Sirt3/Nrf2/HO-1 pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Boyan Zhao, Xiaofan Jiang
Summary: This study used a bioinformatics approach to investigate the pathways and genes involved in ischemic cerebral infarction (ICI) and identified novel biomarkers. The results suggest that hsa-miR-518-5p/hsa-miR-3135b may be involved in ICI progression through the regulation of the REL/SOD2 pathway.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Jialiang Wei, Shuhui Dai, Chen Pu, Peng Luo, Yuefan Yang, Xiaofan Jiang, Xia Li, Wei Lin, Zhou Fei
Summary: TLR9 plays a role in regulating macrophage/microglial function after intracerebral hemorrhage (ICH). The overexpression of TLR9 facilitates macrophage phagocytosis and protects neurons from blood-derived hazards. This protective effect is mediated through the Nrf2/CD204 pathway. These findings may have implications for ICH treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Pediatrics
Xiangyu Gao, Kangyi Yue, Jidong Sun, Zheng Fang, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: The study found through meta-analysis that surgery is an effective and safe treatment for pediatric patients with CCM-related epilepsy. The seizure control rate was 88%, and there was a low risk of postoperative complications and death after surgical excision of CCMs.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Yuefei Zhou, Jialiang Wei, Tao Jin, Yue Hei, Pengfei Jia, Jincai Lin, Shuangwu Yang, Xiaofan Jiang, Weiping Liu, Dakuan Gao
Summary: The suprachiasmatic translamina terminalis (STLT) corridor used in the extended endoscopic endonasal approach (EEEA) is a feasible and practical method for treating intrinsic third ventricle craniopharyngioma (ITVC). A retrospective study was conducted on 14 patients who underwent surgery using EEEA via an STLT corridor. The results showed high rates of gross-total resection and no observed tumor recurrence, with satisfactory outcomes in terms of vision and hypophyseal hormone.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Zhiqiang Yan, Jiang Wang, Qiufeng Dong, Lian Zhu, Wei Lin, Xiaofan Jiang
Summary: This study found through retrospective analysis that age >45 years old, partial tumor resection, tumor diameter >3 cm, and no radiotherapy are independent predictors for tumor progression in glioma patients within 5 years after surgery.
FRONTIERS IN SURGERY
(2022)
Article
Neurosciences
Hongchen Zhang, Wenyu Xie, Yuan Feng, Jialiang Wei, Changbin Yang, Peng Luo, Yuefan Yang, Peng Zhao, Xiaofan Jiang, Wenbin Liang, Shuhui Dai, Xia Li
Summary: The pathophysiological process of neuronal injury due to cerebral ischemia involves disturbances in calcium homeostasis and autophagy. STIM1 has been identified as an important Ca2+ sensor that mediates store-operated Ca2+ entry (SOCE) and is also involved in autophagy. This study found that STIM1 induces impairment of autophagic flux in neurons by promoting SOCE and inhibiting the AKT/mTOR signaling pathway. Inhibition of SOCE or downregulation of STIM1 suppresses autophagic activity in neurons. Moreover, knockdown of stim1 attenuates neurological deficits and brain damage caused by cerebral ischemia, which can be reversed by an AKT/mTOR pathway inhibitor. These findings suggest that STIM1 could be a potential therapeutic target for ischemic stroke.
Article
Cell Biology
Jidong Sun, Chen Pu, ErWan Yang, Hongchen Zhang, Yuan Feng, Peng Luo, Yuefan Yang, Lei Zhang, Xia Li, Xiaofan Jiang, Shuhui Dai
Summary: Intracerebral hemorrhage (ICH) is a deadly stroke type, and inflammation caused by macrophages/microglia (M/Ms) activation is a leading cause of brain damage after ICH. Resveratrol (RSV) has anti-inflammatory effects and has been evaluated in various central nervous system disease models. This study aimed to assess the role of RSV in ICH and investigate its downstream mechanism involving Sirt3.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)