Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferon β and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells

(2019) Naomi Abe-Kanoh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inflammation-induced DNA damage, mutations and cancer

(2019) Jennifer Kay et al.   DNA REPAIR

Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action

(2019) Amin F. Majdalawieh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial

(2019) Alireza Askari et al.   COMPLEMENTARY THERAPIES IN MEDICINE

In this issue: Role of specific and non-specific immunity in disease

(2018) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Identification and evaluation of anti-inflammatory properties of aqueous components extracted from sesame ( Sesamum indicum ) oil

(2018) Pragney Deme et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Sesamin induces ER stress-mediated apoptosis and activates autophagy in cervical cancer cells

(2018) Haowen Dou et al.   LIFE SCIENCES

The recent landscape of cancer research worldwide: a bibliometric and network analysis

(2018) Bernardo Pereira Cabral et al.   Oncotarget

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Black Sesame Seeds Ethanol Extract Ameliorates Hepatic Lipid Accumulation, Oxidative Stress and Insulin Resistance in Fructose-induced Nonalcoholic Fatty Liver Disease

(2018) Yang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression

(2018) Sasimol Udomruk et al.   Journal of Functional Foods

(+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation

(2018) Yihang Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds ( Sesamum indicum )

(2017) Amin F. Majdalawieh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Encapsulation of sesamol in phosphatidyl choline micelles: Enhanced bioavailability and anti-inflammatory activity

(2017) P.S. Yashaswini et al.   FOOD CHEMISTRY

Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity

(2017) P.S. Yashaswini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Daily sesame oil supplementation attenuates local renin-angiotensin system via inhibiting MAPK activation and oxidative stress in cardiac hypertrophy

(2017) Chuan-Teng Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

(2017) Puttaraju Srikantamurthy Yashaswini et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Absorption, distribution, metabolism, and excretion of [14 C]sesamin in rats

(2017) Namino Tomimori et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sesame oil lignans inhibit hepatic endoplasmic reticulum stress and apoptosis in high-fat diet-fed mice

(2017) Mijeong Kim et al.   Journal of Functional Foods

The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2

(2017) M Watanabe et al.   Oncogenesis

Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy

(2017) Zhigang Liu et al.   Scientific Reports

Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism

(2017) Tingxu Yan et al.   Scientific Reports

Sesamol induced apoptotic effect in lung adenocarcinoma cells through both intrinsic and extrinsic pathways

(2016) Boondaree Siriwarin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8

(2016) Shigeru Katayama et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy

(2016) Saif Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

Sesamol induces mitochondrial apoptosis pathway in HCT116 human colon cancer cells via pro-oxidant effect

(2016) Munthipha Khamphio et al.   LIFE SCIENCES

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα

(2016) Ruijuan Zhang et al.   NUTRITION RESEARCH

Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway

(2016) Pengyu Kong et al.   Oncotarget

Phytochemical Contents and Antioxidant and Antiproliferative Activities of Selected Black and White Sesame Seeds

(2016) Lin Zhou et al.   Biomed Research International

Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice

(2015) Li Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Buthionine sulfoximine, an inhibitor of glutathione biosynthesis, induces expression of soluble epoxide hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line: Roles of the NF-κB and MAPK signaling pathways

(2015) Ghada Abdelhamid et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sesamolin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells

(2015) Jeong Hwa Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Norepinephrine Activates Dopamine D4 Receptors in the Rat Lateral Habenula

(2015) D. H. Root et al.   JOURNAL OF NEUROSCIENCE

The role of leukotrienes in allergic diseases

(2015) Min Liu et al.   ALLERGOLOGY INTERNATIONAL

Renin and the (pro)renin receptor in the renal collecting duct: Role in the pathogenesis of hypertension

(2014) Alexis A Gonzalez et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Sesamin increases heme oxygenase-1 protein in RAW 264.7 macrophages through inhibiting its ubiquitination process

(2014) Mizuki Fukunaga et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sesame and resistant starch reduce the colon carcinogenesis and oxidative stress in 1,2-dimethylhydrazine-induced cancer in Wistar rats

(2014) L. Prado-Silva et al.   FOOD RESEARCH INTERNATIONAL

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in ApcMin/+ mice

(2014) Satomi Shimizu et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer

(2014) T. Geetha et al.   JOURNAL OF DRUG TARGETING

Black sesame (Sesamum indicum L.) seeds extracts by CO2 supercritical fluid extraction: Isotherms of global yield, kinetics data, total fatty acids, phytosterols and neuroprotective effects

(2014) José Rafael S. Botelho et al.   JOURNAL OF SUPERCRITICAL FLUIDS

Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide

(2014) Hsiu-Mei Chiang et al.   Journal of the Chinese Medical Association

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

(2014) Saif Ahmad et al.   NEUROTOXICOLOGY

Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats

(2014) Phani Krishna Kondamudi et al.   Pharmacological Reports

Sesamin Induces Cell Cycle Arrest and Apoptosis through the Inhibition of Signal Transducer and Activator of Transcription 3 Signalling in Human Hepatocellular Carcinoma Cell Line HepG2

(2013) Pengyi Deng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects

(2013) Namino Tomimori et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells

(2013) Zhigang Liu et al.   FOOD CHEMISTRY

Innate lymphoid cells: New paradigm in immunology of inflammation

(2013) Vijay Kumar   IMMUNOLOGY LETTERS

Sesamin Protects Mouse Liver against Nickel-Induced Oxidative DNA Damage and Apoptosis by the PI3K-Akt Pathway

(2013) Chan-Min Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sesame oil mitigates nutritional steatohepatitis via attenuation of oxidative stress and inflammation: a tale of two-hit hypothesis

(2013) Srinivasan Periasamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sesame oil attenuates nutritional fibrosing steatohepatitis by modulating matrix metalloproteinases-2, 9 and PPAR-γ

(2013) Srinivasan Periasamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy

(2013) Nehal M. Elsherbiny et al.   LIFE SCIENCES

Hepatic encephalopathy: effects of liver failure on brain function

(2013) Vicente Felipo   NATURE REVIEWS NEUROSCIENCE

Monoamine neurocircuitry in depression and strategies for new treatments

(2013) Michel Hamon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?

(2012) Rai Khalid Farooq et al.   BEHAVIOURAL BRAIN RESEARCH

Sesamin synergistically potentiates the anticancer effects of γ-tocotrienol in mammary cancer cell lines

(2012) Mohamed R. Akl et al.   FITOTERAPIA

Prophylactic Sesame Oil Attenuates Sinusoidal Obstruction Syndrome by Inhibiting Matrix Metalloproteinase–9 and Oxidative Stress

(2012) Srinivasan Periasamy et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy

(2012) Daniel Gologorsky et al.   MEDIATORS OF INFLAMMATION

Chondroprotective and anti-inflammatory effects of sesamin

(2012) Thanyaluck Phitak et al.   PHYTOCHEMISTRY

The hallmarks of cancer

(2012) Tony Gutschner et al.   RNA Biology

Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds

(2011) Nanako Hamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis

(2011) Feng Zhang et al.   CELLULAR SIGNALLING

Sequential Metabolism of Sesamin by Cytochrome P450 and UDP-Glucuronosyltransferase in Human Liver

(2011) K. Yasuda et al.   DRUG METABOLISM AND DISPOSITION

Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

(2011) Zheng Wang et al.   Hepatobiliary & Pancreatic Diseases International

Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10-deficient mice

(2011) Andrew M. Miller et al.   HEPATOLOGY

Sesamolinol Glucoside, Disaminyl Ether, and Other Lignans from Sesame Seeds

(2011) Raphael Grougnet et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Sesamol on Apoptosis and Steroidogenesis in MA-10 Mouse Leydig Tumor Cells

(2011) Ying-Hui Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chondroprotective Role of Sesamol by Inhibiting MMPs Expression via Retaining NF-κB Signaling in Activated SW1353 Cells

(2011) Yung-Chang Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation

(2011) Peiyuan F Hsieh et al.   Journal of Neuroinflammation

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

Comparative Effects of Sesame Seed Lignan and Flaxseed Lignan in Reducing the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen in Athymic Mice

(2011) Jennifer S. Truan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Therapeutic value of sesame oil in the treatment of adhesive small bowel obstruction

(2010) Zhen-Ling Ji et al.   AMERICAN JOURNAL OF SURGERY

Interaction of sesamol (3,4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis

(2010) C. Mahendra Kumar et al.   BIOCHIMIE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Metabolism of Sesamin by Cytochrome P450 in Human Liver Microsomes

(2010) K. Yasuda et al.   DRUG METABOLISM AND DISPOSITION

Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats

(2010) Pei-Yi Chu et al.   FOOD AND CHEMICAL TOXICOLOGY

Sesamin Inhibits Macrophage-Induced Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Expression and Proangiogenic Activity in Breast Cancer Cells

(2010) Chun-Chung Lee et al.   INFLAMMATION

Neutrophils: Cinderella of innate immune system

(2010) V. Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tissue Distribution and Elimination of Estrogenic and Anti-Inflammatory Catechol Metabolites from Sesaminol Triglucoside in Rats

(2010) Kuo-Ching Jan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Bisallylic Mini-lipoxygenase from CyanobacteriumCyanothecesp. That Has an Iron as Cofactor

(2010) Alexandra Andreou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute liver failure

(2010) William Bernal et al.   LANCET

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

(2010) Kuzhuvelil B. Harikumar et al.   MOLECULAR CANCER RESEARCH

Mast cells: Emerging sentinel innate immune cells with diverse role in immunity

(2010) V. Kumar et al.   MOLECULAR IMMUNOLOGY

Apoptosis-inducing action of two products from oxidation of sesamol, an antioxidative constituent of sesame oil: A possible cytotoxicity of oxidized antioxidant

(2010) Aya Fujimoto et al.   TOXICOLOGY IN VITRO

Sesamin Mitigates Inflammation and Oxidative Stress in Endothelial Cells Exposed to Oxidized Low-Density Lipoprotein

(2009) Wen-Jane Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats

(2009) Dur-Zong Hsu et al.   Journal of Functional Foods

Transesterified sesame (Sesamum indicum L.) seed oil as a biodiesel fuel

(2008) A SAYDUT et al.   BIORESOURCE TECHNOLOGY

Sesame Oil Does Not Show Accumulatively Enhanced Protection Against Oxidative Stress–Associated Hepatic Injury in Septic Rats

(2008) Dur-Zong Hsu et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY