Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain

Vanillin and vanillic acid modulate antioxidant defense system via amelioration of metabolic complications linked to Fe2+-induced brain tissues damage

(2020) Veronica F. Salau et al.   METABOLIC BRAIN DISEASE

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

(2020) Yam Nath Paudel et al.   Cells

Therapeutic Potential of Direct Clearance of the Amyloid-β in Alzheimer’s Disease

(2020) Dong Eun Kim et al.   Brain Sciences

RAGE Silencing Ameliorates Neuroinflammation by Inhibition of p38-NF-κB Signaling Pathway in Mouse Model of Parkinson’s Disease

(2020) Xiaoli Wang et al.   Frontiers in Neuroscience

Longifolioside A inhibits TLR4-mediated inflammatory responses by blocking PKCδ activation in LPS-stimulated THP-1 macrophages

(2020) Su Ui Lee et al.   CYTOKINE

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

(2019) Tahir Muhammad et al.   Nutrients

Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway

(2019) Jie Shi et al.   Redox Biology

Nicotinamide Improves Functional Recovery via Regulation of the RAGE/JNK/NF-κB Signaling Pathway after Brain Injury

(2019) Sayed Alam et al.   Journal of Clinical Medicine

Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment

(2019) Ashfaq Ahmad et al.   Journal of Clinical Medicine

Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1/2 and NF-kB pathway

(2019) Nauana Somensi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

(2019) Sudip Dhakal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

(2019) Badshah et al.   Biomolecules

Dose-dependent neuroprotective effect of the JNK inhibitor Brimapitide in 5xFAD transgenic mice

(2019) Baptiste Porte et al.   BRAIN RESEARCH

JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory

(2018) Caroline Morel et al.   JOURNAL OF NEUROSCIENCE

Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice

(2018) Muhammad Sohail Khan et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β42 Activates the Expression of BACE1 Through the JNK Pathway

(2018) Michela Guglielmotto et al.   JOURNAL OF ALZHEIMERS DISEASE

Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus

(2018) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice

(2018) Lifei Liu et al.   PLoS One

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

(2018) Amjad Khan et al.   Frontiers in Pharmacology

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Lithium ameliorates lipopolysaccharide-induced neurotoxicity in the cortex and hippocampus of the adult rat brain

(2017) Muhammad Sohail Khan et al.   NEUROCHEMISTRY INTERNATIONAL

RAGE Plays a Role in LPS-Induced NF-κB Activation and Endothelial Hyperpermeability

(2017) Liqun Wang et al.   SENSORS

Advanced glycation end products and lipopolysaccharides stimulate interleukin‑6 secretion via the RAGE/TLR4‑NF‑κB‑ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages

(2017) Ayaka Ohtsu et al.   Experimental and Therapeutic Medicine

Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice

(2017) Faiz Ul Amin et al.   Scientific Reports

RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?

(2017) Shi Du Yan et al.   JOURNAL OF ALZHEIMERS DISEASE

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

(2016) Miryam Nava Catorce et al.   Current Neuropharmacology

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE–NF-κB Inflammatory Signaling Pathway

(2016) Guangzhi Hao et al.   NEUROCHEMICAL RESEARCH

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway

(2016) Haroon Badshah et al.   Scientific Reports

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice

(2015) Cássia Calixto-Campos et al.   JOURNAL OF NATURAL PRODUCTS

Protective Effect of Lupeol Against Lipopolysaccharide-Induced Neuroinflammation via the p38/c-Jun N-Terminal Kinase Pathway in the Adult Mouse Brain

(2015) Haroon Badshah et al.   Journal of Neuroimmune Pharmacology

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Role of Immunity and Inflammation in the Pathophysiology of Neurodegenerative Diseases

(2015) Marc Fakhoury   Neurodegenerative Diseases

Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development

(2014) D. Malar et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

RAGE/NF-κB Pathway Mediates Lipopolysaccharide-Induced Inflammation in Alveolar Type I Epithelial Cells Isolated from Neonate Rats

(2014) Yuhong Li et al.   INFLAMMATION

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice

(2014) Jayasingh Chellammal Hanish Singh et al.   PHARMACEUTICAL BIOLOGY

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo

(2014) A Sclip et al.   Cell Death & Disease

The roles of protein expression in synaptic plasticity and memory consolidation

(2014) Tali Rosenberg et al.   Frontiers in Molecular Neuroscience

Innate and adaptive immune responses in neurodegeneration and repair

(2013) Sandra Amor et al.   IMMUNOLOGY

RAGE regulation and signaling in inflammation and beyond

(2013) Katrin Kierdorf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

(2013) Mingyan Liu et al.   MOLECULAR NEUROBIOLOGY

Fisetin Enhances Behavioral Performances and Attenuates Reactive Gliosis and Inflammation During Aluminum Chloride-Induced Neurotoxicity

(2013) Dharmalingam Prakash et al.   NEUROMOLECULAR MEDICINE

Is RAGE still a therapeutic target for Alzheimer’s disease?

(2012) Richard J Deane   Future Medicinal Chemistry

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Synapses and Memory Storage

(2012) M. Mayford et al.   Cold Spring Harbor Perspectives in Biology

Vanillic acid inhibits inflammatory mediators by suppressing NF-κB in lipopolysaccharide-stimulated mouse peritoneal macrophages

(2011) Min-Cheol Kim et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

c-Jun N-terminal Kinase Regulates Soluble Aβ Oligomers and Cognitive Impairment in AD Mouse Model

(2011) Alessandra Sclip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS

(2011) Y. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway

(2011) Dong-Young Choi et al.   NEUROCHEMISTRY INTERNATIONAL

Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound inl-NAME-induced hypertensive rats: A dose-dependence study

(2011) Subramanian Kumar et al.   REDOX REPORT

Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1–42) associated with decrease of apoptotic factors

(2010) Mahmoudreza Ramin et al.   BEHAVIOURAL BRAIN RESEARCH

Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis

(2010) Asadollah Zarifkar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

RAGE: therapeutic target and biomarker of the inflammatory response-the evidence mounts

(2009) Ravichandran Ramasamy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE