Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis

(2018) Mei-ting Song et al.   ACTA PHARMACOLOGICA SINICA

Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat

(2018) Cai Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Depression and sterile inflammation: Essential role of danger associated molecular patterns

(2018) Tina C. Franklin et al.   BRAIN BEHAVIOR AND IMMUNITY

Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats

(2018) Hai Zhang et al.   Brain Structure & Function

Perilla aldehyde attenuates CUMS-induced depressive-like behaviors via regulating TXNIP/TRX/NLRP3 pathway in rats

(2018) Yichen Song et al.   LIFE SCIENCES

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

(2018) Adam K. Walker et al.   MOLECULAR PSYCHIATRY

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

(2018) Amanda Santiago et al.   NEUROPHARMACOLOGY

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

(2018) Anindya Bhattacharya et al.   NEUROPSYCHOPHARMACOLOGY

Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats

(2018) Xiu-Ling Zhu et al.   PSYCHOPHARMACOLOGY

TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice

(2018) Yihe Wang et al.   NEURAL PLASTICITY

Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation

(2018) Dool-Ri Oh et al.   Frontiers in Pharmacology

Influence of hippocampal low-frequency stimulation on GABAA R α1, ICER and BNDF expression level in brain tissues of amygdala-kindled drug-resistant temporal lobe epileptic rats

(2018) Kaya Xu et al.   BRAIN RESEARCH

Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression

(2018) Chen-Yi-Yu Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus

(2018) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response

(2018) Shariful A. Syed et al.   NEURON

Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration

(2018) Minqing Gu et al.   Nutrients

Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling

(2018) Huachao Li et al.   MOLECULES

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway

(2018) Shuang Deng et al.   BIOMEDICINE & PHARMACOTHERAPY

Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

(2017) Shanshan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex

(2017) Xiaoxin Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model

(2017) Avi Fellner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characteristics of primary rat microglia isolated from mixed cultures using two different methods

(2017) Li Lin et al.   Journal of Neuroinflammation

Pleiotrophin regulates microglia-mediated neuroinflammation

(2017) Rosalía Fernández-Calle et al.   Journal of Neuroinflammation

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress

(2017) Dan Zhao et al.   Journal of Neuroinflammation

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice

(2017) Vishnu N Thakare et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson's disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway

(2017) Shuai Shao et al.   Molecular Medicine Reports

Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice

(2017) Sophia Yui Kau Fong et al.   MOLECULAR PHARMACEUTICS

Baicalin protects neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the phosphoinositide 3-kinase/protein kinase B signaling pathway

(2017) Xiao-hua Yan et al.   Neural Regeneration Research

Metabolic and inflammatory markers: associations with individual depressive symptoms

(2017) F. Lamers et al.   PSYCHOLOGICAL MEDICINE

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

(2017) Wei Liang et al.   Aging and Disease

Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway

(2017) Ping Cheng et al.   Frontiers in Pharmacology

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

(2016) Yuyan Cheng et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experimental periodontitis

(2016) Jun-Yi Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

(2016) Monika Fleshner et al.   NEUROPSYCHOPHARMACOLOGY

Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways

(2016) Daiying Zuo et al.   NEUROTOXICITY RESEARCH

PTEN–Foxo1 signaling triggers HMGB1-mediated innate immune responses in acute lung injury

(2015) Min Zhou et al.   IMMUNOLOGIC RESEARCH

Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle

(2015) Akira Wagatsuma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Apelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and MEK/Erk pathways

(2015) Li Chen et al.   Science China-Life Sciences

Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats

(2014) Hai-Yang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation

(2014) Li Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway

(2014) Hongquan Dong et al.   Journal of Neuroinflammation

Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

(2014) Iciar Gárate et al.   Journal of Neuroinflammation

The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons

(2014) M. Zhao et al.   NEUROSCIENCE

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

(2014) George M. Slavich et al.   PSYCHOLOGICAL BULLETIN

Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action

(2013) Hong Jiang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

(2012) So Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stress-Induced Neuroinflammation: Role of the Toll-Like Receptor-4 Pathway

(2012) Iciar Gárate et al.   BIOLOGICAL PSYCHIATRY

The PI3K/Akt pathway is required for LPS activation of microglial cells

(2012) Concetta Saponaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Phosphatidylinositol 3-kinase/Akt Signaling Pathway Mediates Acupuncture-Induced Dopaminergic Neuron Protection and Motor Function Improvement in a Mouse Model of Parkinson's Disease

(2011) Seung-Nam Kim et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression

(2011) Iciar Gárate et al.   Journal of Neuroinflammation

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

(2010) WuQiang Fan et al.   EMBO JOURNAL

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

(2010) Yuma Sonoda et al.   NEUROSCIENCE LETTERS

Baicalin in Radical Scavenging and Its Synergistic Effect with β-Carotene in Antilipoxidation

(2009) Ran Liang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis

(2008) Zongfang Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry

(2008) H HUANG et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE