Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

Neuroprotective effect of monophosphoryl lipid A, a detoxified lipid A derivative, in photothrombotic model of unilateral selective hippocampal ischemia in rat

(2018) Sayed Masoud Hosseini et al.   BEHAVIOURAL BRAIN RESEARCH

T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention

(2018) Jamie van Langelaar et al.   BRAIN

Sulfated vizantin induces formation of macrophage extracellular traps

(2018) Masataka Oda et al.   MICROBIOLOGY AND IMMUNOLOGY

Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease–related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence

(2018) Hamid Gholami Pourbadie et al.   NEUROBIOLOGY OF AGING

The interaction of α-synuclein and Tau: A molecular conspiracy in neurodegeneration?

(2018) Xu Yan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Toll-like receptor 4 modulation influences human neural stem cell proliferation and differentiation

(2018) Chiara Grasselli et al.   Cell Death & Disease

Molecular modeling reveals the inhibition mechanism and binding mode of ursolic acid to TLR4-MD2

(2018) Xiaodi Niu et al.   Computational and Theoretical Chemistry

High expression of the HMGB1-TLR4 axis and its downstream signaling factors in patients with Parkinson's disease and the relationship of pathological staging

(2018) Yi Yang et al.   Brain and Behavior

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

(2018) Cecilia Chavarría et al.   BIOCHEMICAL JOURNAL

The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling

(2018) Charys Palmer et al.   Innate Immunity

Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model

(2018) Ying Han et al.   Neuroscience Bulletin

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

(2018) Yam Nath Paudel et al.   Frontiers in Neuroscience

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

(2017) Angela Gomez-Arboledas et al.   GLIA

E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord

(2017) Jamie S. Church et al.   GLIA

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model

(2017) Avi Fellner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons

(2017) María Calvo-Rodríguez et al.   Journal of Neuroinflammation

Characterization of the Ionic Profile of the Extracellular Space of the Injured and Ischemic Brain: A Microdialysis Study

(2017) Tamara Martínez-Valverde et al.   JOURNAL OF NEUROTRAUMA

The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats

(2017) Long-Fei Pan et al.   Molecular Medicine Reports

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells and protects mice from lethal influenza infection

(2017) Laure Perrin-Cocon et al.   Scientific Reports

Brain recovery mediated by toll-like receptor 4 in rats after intracerebral hemorrhage

(2016) Chunyan Lei et al.   BRAIN RESEARCH

Chemical Hybridization of Vizantin and Lipid A to Generate a Novel LPS Antagonist

(2016) Hirofumi Yamamoto et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Anti-IL-5 for Severe Asthma

(2016) Richard Russell et al.   CHEST

Toll-Like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice

(2016) Shigeki Nakamura et al.   INFECTION AND IMMUNITY

Monophosphoryl Lipid-A: A Promising Tool for Alzheimer’s Disease Toll

(2016) Ângela Rego et al.   JOURNAL OF ALZHEIMERS DISEASE

Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons

(2016) Yi Shen et al.   JOURNAL OF CELL BIOLOGY

Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility

(2016) Christian Henneberger et al.   JOURNAL OF CELL BIOLOGY

Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic Mice

(2016) Yiren Qin et al.   JOURNAL OF IMMUNOLOGY

TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord

(2016) J. S. Church et al.   JOURNAL OF NEUROSCIENCE

The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation

(2016) Monica Molteni et al.   MEDIATORS OF INFLAMMATION

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

(2016) Qiuyang Zheng et al.   Frontiers in Aging Neuroscience

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury

(2016) Tonny V. Veenith et al.   JAMA Neurology

TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation

(2016) L Aurelian et al.   Translational Psychiatry

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

(2015) Emmy H. Rannikko et al.   BMC NEUROSCIENCE

Toll-like receptor 4 signaling: A common biological mechanism of regimen-related toxicities

(2015) Hannah R. Wardill et al.   CANCER TREATMENT REVIEWS

Oligodendrocytes and Alzheimer's disease

(2015) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

(2015) Peter H. Goff et al.   JOURNAL OF VIROLOGY

The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2/TLR4 receptor complex

(2015) Alja Oblak et al.   MOLECULAR IMMUNOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Amyloid deposition in Parkinson's disease and cognitive impairment: A systematic review

(2015) Myria Petrou et al.   MOVEMENT DISORDERS

Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease

(2015) Stephen Mullin et al.   NEUROLOGIC CLINICS

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Systemic Inflammation and the Brain: Novel Roles of Genetic, Molecular, and Environmental Cues as Drivers of Neurodegeneration

(2015) Roman Sankowski et al.   Frontiers in Cellular Neuroscience

Macrophage subsets and microglia in multiple sclerosis

(2014) Jeroen F. J. Bogie et al.   ACTA NEUROPATHOLOGICA

HTT-lowering reverses Huntington’s disease immune dysfunction caused by NFκB pathway dysregulation

(2014) Ulrike Träger et al.   BRAIN

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

(2014) Agnieszka Płóciennikowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-like receptor 4 deficiency impairs microglial phagocytosis of degenerating axons

(2014) Labchan Rajbhandari et al.   GLIA

Expression and Functional Significance of SOCS-1 and SOCS-3 in Astrocytes

(2014) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Vizantin Inhibits Endotoxin-Mediated Immune Responses via the TLR 4/MD-2 Complex

(2014) Masataka Oda et al.   JOURNAL OF IMMUNOLOGY

Euodenine A: A Small-Molecule Agonist of Human TLR4

(2014) Juliette E. Neve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

(2014) Mathieu Bourdenx et al.   Frontiers in Neuroanatomy

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic

(2013) Roberto Cighetti et al.   CHEMBIOCHEM

Toll-Like Receptor 4 Agonistic Antibody Promotes Innate Immunity against Severe Pneumonia Induced by Coinfection with Influenza Virus and Streptococcus pneumoniae

(2013) Akitaka Tanaka et al.   Clinical and Vaccine Immunology

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

(2013) Linli Yao et al.   Journal of Neuroinflammation

Experimental Traumatic Brain Injury Induces Rapid Aggregation and Oligomerization of Amyloid-Beta in an Alzheimer's Disease Mouse Model

(2013) Patricia M. Washington et al.   JOURNAL OF NEUROTRAUMA

The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy

(2013) Miao Lin et al.   KIDNEY INTERNATIONAL

Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure

(2013) Naina Shah et al.   LIVER TRANSPLANTATION

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

(2013) Kurt Lucas et al.   MOLECULAR NEUROBIOLOGY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Reduced Surface Expression of TLR4 by a V254I Point Mutation Accounts for the Low Lipopolysaccharide Responder Phenotype of BALB/c B Cells

(2012) H. Tsukamoto et al.   JOURNAL OF IMMUNOLOGY

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(2012) Massimiliano DePaola et al.   MOLECULAR MEDICINE

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(2012) K. Schroder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

(2012) Yukiya Suzuki et al.   Scientific Reports

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipopolysaccharide delays demyelination and promotes oligodendrocyte precursor proliferation in the central nervous system

(2011) Thomas Skripuletz et al.   BRAIN BEHAVIOR AND IMMUNITY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Phagocytosis

(2011) Roberto J. Botelho et al.   CURRENT BIOLOGY

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management

(2011) M. Gambuzza et al.   JOURNAL OF NEUROIMMUNOLOGY

Quantitative Relationship between Axonal Injury and Mechanical Response in a Rodent Head Impact Acceleration Model

(2011) Yan Li et al.   JOURNAL OF NEUROTRAUMA

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

TLR2 activation inhibits embryonic neural progenitor cell proliferation

(2010) Eitan Okun et al.   JOURNAL OF NEUROCHEMISTRY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Regulation of autoimmune encephalomyelitis by toll-like receptors

(2009) Monica Marta et al.   AUTOIMMUNITY REVIEWS

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Molecular Pathology of Lewy Body Diseases

(2009) Katrin Beyer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

(2009) B. Marsh et al.   JOURNAL OF NEUROSCIENCE

Lipopolysaccharide: Biosynthetic pathway and structure modification

(2009) Xiaoyuan Wang et al.   PROGRESS IN LIPID RESEARCH

Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease

(2008) Ana María Estrada Sánchez et al.   ARCHIVES OF MEDICAL RESEARCH

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

(2008) Monica Marta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A novel TLR4-binding peptide that inhibits LPS-induced activation of NF-κB and in vivo toxicity

(2008) Kei-ichi Sugiyama et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

Upregulated Expression of Toll-Like Receptor 4 in Monocytes Correlates with Severity of Acute Cerebral Infarction

(2008) Qing-wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Striatal β-Amyloid Deposition in Parkinson Disease With Dementia

(2008) Michail E. Kalaitzakis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cyanobacterial LPS antagonist (CyP)—A novel and efficient inhibitor of Escherichia coli LPS-induced cytokine response in the pig

(2008) Ebbe Billmann Thorgersen et al.   MOLECULAR IMMUNOLOGY