Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review

Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies

(2020) Qiong Lai et al.   ACTA PHARMACOLOGICA SINICA

Evidence of anti-inflammatory activity of Schizandrin A in animal models of acute inflammation

(2020) Likun Cui et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway

(2020) Wang Cuiqiong et al.   Artificial Cells Nanomedicine and Biotechnology

Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through the wingless/integrase-1 signaling pathway

(2020) Ying Wang et al.   EXPERIMENTAL LUNG RESEARCH

Schizandrin attenuates inflammation induced by avian pathogenic Escherichia coli in chicken type II pneumocytes

(2020) Meng Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The effects of inhibiting the activation of hepatic stellate cells by lignan components from the fruits of Schisandra chinensis and the mechanism of schisanhenol

(2020) Xiaoli He et al.   Journal of Natural Medicines

Schizandrin attenuates lung lesions induced by Avian pathogenic Escherichia coli in chickens

(2020) Meng Yuan et al.   MICROBIAL PATHOGENESIS

Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders

(2020) Eva Gil-Martins et al.   PHARMACOLOGY & THERAPEUTICS

Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in Ang II-challenged vascular endothelium

(2019) Jibo Han et al.   PHYTOTHERAPY RESEARCH

Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes

(2019) Chang Tu et al.   Frontiers in Pharmacology

Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives

(2019) Adriana Nowak et al.   Nutrients

Protective effect of Schisandra chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway

(2019) Lianlin Su et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC–Q-TOF-MS

(2019) Mengying Wei et al.   MOLECULES

Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3

(2019) Xuehua Zhang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Schisandrin B ameliorates high glucose-induced vascular endothelial cells injury by regulating Noxa/Hsp27/NF-κB signaling pathway

(2019) Qiu-Ning Lin et al.   Biochemistry and Cell Biology

Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway

(2019) Xiaohong Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer

(2019) Haibing Xian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology

(2019) Fangbo Xia et al.   PHYTOMEDICINE

Schizandrin B attenuates angiotensin II induced endothelial to mesenchymal transition in vascular endothelium by suppressing NF-κB activation

(2019) Shengban You et al.   PHYTOMEDICINE

Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

(2019) Hima Dhakal et al.   Frontiers in Pharmacology

Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model

(2019) Yeguo Yang et al.   Aging-US

Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells

(2019) Zishu Wang et al.   BIOCHEMICAL PHARMACOLOGY

Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy

(2019) Dianwen Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress

(2019) Ling Cheng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The neuroprotective effect of schisandrol A on 6-OHDA-induced PD mice may be related to PI3K/AKT and IKK/IκBα/NF-κB pathway

(2019) Tingxu Yan et al.   EXPERIMENTAL GERONTOLOGY

Effect of gomisin A on osteoblast differentiation in high glucose-mediated oxidative stress

(2019) Jyoti Shrestha Takanche et al.   PHYTOMEDICINE

Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes

(2019) Yo-Han Han et al.   PHYTOMEDICINE

Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT

(2019) Guangxu Cao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation

(2019) Murphy L. Y. Wan et al.   Scientific Reports

Schizandrin A Protects Human Retinal Pigment Epithelial Cell Line ARPE-19 against HG-Induced Cell Injury by Regulation of miR-145

(2019) Yi Dong et al.   Molecular Therapy-Nucleic Acids

Schisandrin B alleviates acute oxidative stress via modulating Nrf2/Keap1-mediated antioxidant pathway

(2018) Wu Ying et al.   Applied Physiology Nutrition and Metabolism

Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195

(2018) Dongfang Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

(2018) Kandhasamy Sowndhararajan et al.   BIOMEDICINE & PHARMACOTHERAPY

Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression

(2018) Sony Maharjan et al.   Biomolecules & Therapeutics

Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1

(2018) Sony Maharjan et al.   Biomolecules & Therapeutics

Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation

(2018) Chuwen Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

New insights into TGF-β/Smad signaling in tissue fibrosis

(2018) He-He Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells

(2018) Jeong-Seok Kim et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents

(2018) Devi Amujuri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Schisandrol B promotes liver regeneration after partial hepatectomy in mice

(2018) Xi Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF- kB pathway

(2018) Bin LI et al.   EXPERIMENTAL ANIMALS

Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis

(2018) Arulkumar Nagappan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique

(2018) Yuan Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Schisantherin A protects renal tubular epithelial cells from hypoxia/reoxygenation injury through the activation of PI3K/Akt signaling pathway

(2018) Jiachuan Gong et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

Lignans from Schisandra chinensis rattan stems suppresses primary Aβ1-42-induced microglia activation via NF-κB/MAPK signaling pathway

(2018) Bingyou Yang et al.   NATURAL PRODUCT RESEARCH

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

(2018) Jisheng Ran et al.   Drug Design Development and Therapy

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Schizandrin A Alleviates LPS-Induced Injury in Human Keratinocyte Cell Hacat Through a MicroRNA-127-Dependent Regulation

(2018) Shujie Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress

(2018) Arulkumar Nagappan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Schisandrin B exhibits potent anticancer activity in triple negative breast cancer by inhibiting STAT3

(2018) Xuanxuan Dai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

(2018) Ji-Ye Kee et al.   Frontiers in Pharmacology

Schisandra chinensis inhibiting TGFβ-induced activation of hepatic stellate cells

(2018) Soon Young Shin et al.   Applied Biological Chemistry

Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress

(2018) Zhenxin Mou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4

(2018) Zhi-Rong Ji et al.   INFLAMMATION

Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway

(2018) Jian-Hua Qin et al.   INFLAMMATION

Schisandra Chinensis Lignans Suppresses the Production of Inflammatory Mediators Regulated by NF-κB, AP-1, and IRF3 in Lipopolysaccharide-Stimulated RAW264.7 Cells

(2018) Gan Luo et al.   MOLECULES

Schisandrin B attenuates epidural fibrosis in postlaminectomy rats by inhibiting proliferation and extracellular matrix production of fibroblasts

(2018) Haiming Jin et al.   PHYTOTHERAPY RESEARCH

Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway

(2018) Jibo Han et al.   Drug Design Development and Therapy

Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver

(2018) Shan Feng et al.   Drug Design Development and Therapy

Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies

(2017) B. Poornima et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Schisandra Lignan Extract Protects against Carbon Tetrachloride-Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF-κB and JNK Signaling Pathways

(2017) Qingshan Chen et al.   Evidence-based Complementary and Alternative Medicine

Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation

(2017) Miaomiao Guo et al.   INFLAMMATION

Anti-Inflammatory Effects of Schisandrin B on LPS-Stimulated BV2 Microglia via Activating PPAR-γ

(2017) Na Liu et al.   INFLAMMATION

Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells

(2017) J. S. Takanche et al.   INTERNATIONAL ENDODONTIC JOURNAL

Protective effects of Schisandrin B on cigarette smoke-induced airway injury in mice through Nrf2 pathway

(2017) Ruichun Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4

(2017) Di Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy

(2017) Qiao Lai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Schisandrin B inhibits LPS-induced inflammatory response in human umbilical vein endothelial cells by activating Nrf2

(2017) Qiuning Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Schisantherin A protects against liver ischemia-reperfusion injury via inhibition of mitogen-activated protein kinase pathway

(2017) Nanxin Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes

(2017) Jae Chae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats

(2017) D.Q. Xin et al.   Molecular Medicine Reports

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms

(2017) Jeong-Seok Kim et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Schisandrin B inhibits the proliferation and invasion of glioma cells by regulating the HOTAIR–micoRNA-125a–mTOR pathway

(2017) Yan Jiang et al.   NEUROREPORT

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

(2017) Qingshan Chen et al.   Drug Design Development and Therapy

Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin

(2017) Shengpeng Wang et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway

(2016) Yi-ming Jiang et al.   ACTA PHARMACOLOGICA SINICA

Suppression of P2X7/NF-κB pathways by Schisandrin B contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury

(2016) Zhiyong Cai et al.   ARCHIVES OF PHARMACAL RESEARCH

Schisandrin B inhibits the proliferation of airway smooth muscle cells via microRNA-135a suppressing the expression of transient receptor potential channel 1

(2016) Xiao-yu Zhang et al.   CELL BIOLOGY INTERNATIONAL

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation

(2016) Shiyao Liao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells

(2016) Yoshitaka Hosokawa et al.   INFLAMMATION

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

(2016) Agnieszka Szopa et al.   PHYTOCHEMISTRY REVIEWS

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasomein vitroandin vivo

(2015) Pou Kuan Leong et al.   BIOFACTORS

Schisandrin B suppresses glioma cell metastasis mediated by inhibition of mTOR/MMP-9 signal pathway

(2015) Yan Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation

(2015) Yiming Jiang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Schizandrin inhibits fibrosis and epithelial–mesenchymal transition in transforming growth factor-β1-stimulated AML12 cells

(2015) Ji-hyun Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells

(2015) Myungsuk Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways

(2015) Lun Qing Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases

(2015) En-Ping Jiang et al.   NEUROREPORT

Extracts and lignans of Schisandra chinensis fruit alter lipid and glucose metabolism in vivo and in vitro

(2015) Haitao Liu et al.   Journal of Functional Foods

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

(2015) Hossam M. Abdallah et al.   Journal of Advanced Research

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

(2015) Rajarajan A. Thandavarayan et al.   PLoS One

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

(2015) Vijayasree V. Giridharan et al.   PLoS One

PI3K/Akt-mediated regulation of p53 in cancer

(2014) Aswin G. Abraham et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of NF-κB by ubiquitination

(2013) Jueqi Chen et al.   CURRENT OPINION IN IMMUNOLOGY

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

(2010) M.A. Bradley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE