Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation

Human DNA-PK activates a STING-independent DNA sensing pathway

(2020) Katelyn Burleigh et al.   Science Immunology

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

(2020) Chuanhui Han et al.   NATURE IMMUNOLOGY

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

(2020) Jianjun Wu et al.   IMMUNITY

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

(2019) Yuk Yuen Lan et al.   AGING CELL

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods

(2019) Dingyan Wang et al.   Frontiers in Pharmacology

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

(2019) Guillaume Voisinne et al.   NATURE IMMUNOLOGY

DNA damage, metabolism and aging in pro-inflammatory T cells

(2018) Yinyin Li et al.   EXPERIMENTAL GERONTOLOGY

Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

(2018) Zhizhang Wang et al.   IMMUNITY

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

(2018) Xingli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4

(2017) Jing Xing et al.   Journal of Chemical Information and Modeling

STING is an essential mediator of the Ku70-mediated production of IFN-λ1 in response to exogenous DNA

(2017) Hongyan Sui et al.   Science Signaling

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

STING is an essential mediator of the Ku70-mediated production of IFN-λ1 in response to exogenous DNA

(2017) Hongyan Sui et al.   Science Signaling

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Systemic DNA damage responses in aging and diseases

(2016) Flavia Ribezzo et al.   SEMINARS IN CANCER BIOLOGY

Aging and DNA damage in humans: a meta-analysis study

(2016) Jorge Pinto Soares et al.   Aging-US

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

(2014) Jinfeng Liu et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

T-cell aging in rheumatoid arthritis

(2013) Cornelia M. Weyand et al.   CURRENT OPINION IN RHEUMATOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Sensing the Dark Side of DNA

(2013) L. A. J. O'Neill   SCIENCE

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

(2011) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

(2010) Daniel Cejka et al.   ARTHRITIS AND RHEUMATISM

DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis

(2010) Lan Shao et al.   EMBO Molecular Medicine

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL