Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure

(2009) Heiko Bugger et al.   CARDIOVASCULAR RESEARCH

Mitochondrial DNA (mtDNA) Biogenesis: Visualization and Duel Incorporation of BrdU and EdU Into Newly Synthesized mtDNA In Vitro

(2009) Stephen I. Lentz et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE