Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

(2021) Mikolaj Ogrodnik et al.   AGING CELL

NAD + supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy

(2021) Beimeng Yang et al.   AGING CELL

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aspirin meets cGAS

(2019) Keith B. Elkon   Nature Reviews Rheumatology

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

(2019) Yuk Yuen Lan et al.   AGING CELL

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Chromosome instability syndromes

(2019) A. Malcolm R. Taylor et al.   Nature Reviews Disease Primers

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

(2019) Julio Aguado et al.   Nature Communications

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration

(2018) David Gosselin et al.   NEURON

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

(2017) Florian T. Merkle et al.   NATURE

New Role of ATM in Controlling GABAergic Tone During Development

(2016) Lara Pizzamiglio et al.   CEREBRAL CORTEX

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

(2016) Samantha S.W. Ho et al.   IMMUNITY

Ataxia telangiectasia: a review

(2016) Cynthia Rothblum-Oviatt et al.   Orphanet Journal of Rare Diseases

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The appropriateness of the mouse model for ataxia-telangiectasia: Neurological defects but no neurodegeneration

(2013) Martin F. Lavin   DNA REPAIR

A patient-derived olfactory stem cell disease model for ataxia-telangiectasia

(2013) Romal Stewart et al.   HUMAN MOLECULAR GENETICS

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

Neurologic Presentation in Children with Ataxia-Telangiectasia: Is Small Head Circumference a Hallmark of the Disease?

(2011) Andreea Nissenkorn et al.   JOURNAL OF PEDIATRICS

Association of micronucleus frequency with neurodegenerative diseases

(2010) L. Migliore et al.   MUTAGENESIS