Cellular senescence mediates fibrotic pulmonary disease

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis

(2016) Yuejuan Li et al.   MATRIX BIOLOGY

Trade talk: Neuro connector

(2016) Monya Baker   NATURE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

(2015) Hagai Yanai et al.   Aging-US

A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis

(2015) Yasmina Bauer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Idiopathic pulmonary fibrosis: An update

(2015) Paolo Spagnolo et al.   ANNALS OF MEDICINE

Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts

(2015) Hyun Lim et al.   BIOCHEMICAL PHARMACOLOGY

VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis

(2015) Marianna Agassandian et al.   CELLULAR SIGNALLING

Translational models of lung disease

(2015) Paul F. Mercer et al.   CLINICAL SCIENCE

Pirfenidone: A Review of Its Use in Idiopathic Pulmonary Fibrosis

(2015) Esther S. Kim et al.   DRUGS

Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

(2015) Cheresa Calhoun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure

(2014) Koji Iijima et al.   JOURNAL OF IMMUNOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

(2013) Kazutetsu Aoshiba et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Abnormal Lung Aging in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2012) Rosa Faner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Removing technical variability in RNA-seq data using conditional quantile normalization

(2012) K. D. Hansen et al.   BIOSTATISTICS

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Determining When Enhanced Pause (Penh) is Sensitive to Changes in Specific Airway Resistance

(2011) David G. Frazer et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

(2010) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Noninvasive and Invasive Pulmonary Function in Mouse Models of Obstructive and Restrictive Respiratory Diseases

(2009) Jeroen A. J. Vanoirbeek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Standardized quantification of pulmonary fibrosis in histological samples

(2008) Ralf-Harto Hübner et al.   BIOTECHNIQUES

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL