New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences

(2016) Afshan N. Malik et al.   MITOCHONDRION

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

SAMHD1: At the Crossroads of Cell Proliferation, Immune Responses, and Virus Restriction

(2015) Ester Ballana et al.   TRENDS IN MICROBIOLOGY

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation

(2008) Yen-Ling Chen et al.   GENES TO CELLS

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY