Structural basis for sequestration and autoinhibition of cGAS by chromatin
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structural basis for sequestration and autoinhibition of cGAS by chromatin
Authors
Keywords
-
Journal
NATURE
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-11
DOI
10.1038/s41586-020-2748-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular mechanisms and cellular functions of cGAS–STING signalling
- (2020) Karl-Peter Hopfner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
- (2019) Matteo Gentili et al. Cell Reports
- cGAS in action: Expanding roles in immunity and inflammation
- (2019) Andrea Ablasser et al. SCIENCE
- The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
- (2019) Christian Zierhut et al. CELL
- DNA sensing by the cGAS–STING pathway in health and disease
- (2019) Mona Motwani et al. NATURE REVIEWS GENETICS
- Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
- (2019) Hui Jiang et al. EMBO JOURNAL
- cGAS and CD-NTase enzymes: structure, mechanism, and evolution
- (2019) Philip J Kranzusch CURRENT OPINION IN STRUCTURAL BIOLOGY
- Tight nuclear tethering of cGAS is essential for preventing autoreactivity
- (2019) Hannah E Volkman et al. eLife
- DNA-induced liquid phase condensation of cGAS activates innate immune signaling
- (2018) Mingjian Du et al. SCIENCE
- Structural basis of mitochondrial receptor binding and constriction by DRP1
- (2018) Raghav Kalia et al. NATURE
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- The allosteric activation of cGAS underpins its dynamic signaling landscape
- (2018) Richard M Hooy et al. eLife
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
- (2017) Liudmila Andreeva et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Addressing preferred specimen orientation in single-particle cryo-EM through tilting
- (2017) Yong Zi Tan et al. NATURE METHODS
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Recognition of the nucleosome by chromatin factors and enzymes
- (2016) Robert K McGinty et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
- (2015) Anna-Maria Herzner et al. NATURE IMMUNOLOGY
- OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines
- (2014) Jonathan L. Schmid-Burgk et al. GENOME RESEARCH
- Rapid Purification of Recombinant Histones
- (2014) Henrike Klinker et al. PLoS One
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
- (2014) Xu Zhang et al. Cell Reports
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- A Tale of Tails: How Histone Tails Mediate Chromatin Compaction in Different Salt and Linker Histone Environments†
- (2009) Gaurav Arya et al. JOURNAL OF PHYSICAL CHEMISTRY A
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More