Micronuclei and Genome Chaos: Changing the System Inheritance

Nonclonal Chromosome Aberrations and Genome Chaos in Somatic and Germ Cells from Patients and Survivors of Hodgkin Lymphoma

(2019) Sara Frias et al.   Genes

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

(2019) Junsong Chen et al.   CURRENT CANCER DRUG TARGETS

A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity

(2018) David Díaz-Carballo et al.   CANCER RESEARCH

Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems

(2018) Christine J. Ye et al.   Molecular Cytogenetics

Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer Treatment

(2018) et al.   Cancers

Altered nuclear envelope structure and proteasome function of micronuclei

(2018) Kendra K. Maass et al.   EXPERIMENTAL CELL RESEARCH

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Role of chromosomal instability in cancer progression

(2017) Sarah E McClelland   ENDOCRINE-RELATED CANCER

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

DNA damage-induced immune response: Micronuclei provide key platform

(2017) Nelson O. Gekara   JOURNAL OF CELL BIOLOGY

Transient and stable vector transfection: Pitfalls, off-target effects, artifacts

(2017) Aleksei A. Stepanenko et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Entosis Is Induced by Glucose Starvation

(2017) Jens C. Hamann et al.   Cell Reports

New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response

(2017) Nelson Rangel et al.   Genes

The Role of Chromosomal Instability in Cancer and Therapeutic Responses

(2017) Natalia Vargas-Rondón et al.   Cancers

Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA

(2016) Cody W. Lewis et al.   CELL CYCLE

Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance)

(2016) C. Niederwieser et al.   HAEMATOLOGICA

Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans

(2016) Michael Fenech et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Why it is crucial to analyze non clonal chromosome aberrations or NCCAs?

(2016) Henry H. Q. Heng et al.   Molecular Cytogenetics

Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance)

(2016) C. Niederwieser et al.   HAEMATOLOGICA

Linking Micronuclei to Chromosome Fragmentation

(2015) Emily M. Hatch et al.   CELL

Clinical application of micronucleus test in exfoliated buccal cells: A systematic review and metanalysis

(2015) Claudia Bolognesi et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Genome chaos: Survival strategy during crisis

(2014) Guo Liu et al.   CELL CYCLE

Evolutionary mechanism unifies the hallmarks of cancer

(2014) Steven D. Horne et al.   INTERNATIONAL JOURNAL OF CANCER

Fast Image Analysis for the Micronucleus Assay in a Fully Automated High-Throughput Biodosimetry System

(2014) Oleksandra V. Lyulko et al.   RADIATION RESEARCH

Stress, genomic adaptation, and the evolutionary trade-off

(2014) Steven D. Horne et al.   Frontiers in Genetics

Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution

(2013) Henry H. Heng et al.   CANCER AND METASTASIS REVIEWS

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Single cell heterogeneity

(2013) Batoul Y Abdallah et al.   CELL CYCLE

Karyotype Heterogeneity and Unclassified Chromosomal Abnormalities

(2013) H.H.Q. Heng et al.   CYTOGENETIC AND GENOME RESEARCH

Heterogeneity of Cell Death

(2013) J.B. Stevens et al.   CYTOGENETIC AND GENOME RESEARCH

Unstable genomes elevate transcriptome dynamics

(2013) Joshua B. Stevens et al.   INTERNATIONAL JOURNAL OF CANCER

Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells

(2013) Wei Ji et al.   INTERNATIONAL JOURNAL OF CANCER

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Howell-Jolly Bodies: A Brief Historical Review

(2011) David A. Sears et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Decoding the genome beyond sequencing: The new phase of genomic research

(2011) Henry H.Q. Heng et al.   GENOMICS

Diverse system stresses: common mechanisms of chromosome fragmentation

(2011) J B Stevens et al.   Cell Death & Disease

Micronuclei levels in peripheral blood lymphocytes as a potential biomarker for pancreatic cancer risk

(2010) P. Chang et al.   CARCINOGENESIS

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Molecular Cytogenetic Diagnosis and Somatic Genome Variations

(2010) S. Vorsanova et al.   CURRENT GENOMICS

The evolutionary mechanism of cancer

(2010) Henry H.Q. Heng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Application and adaptation of the in vitro micronucleus assay for the assessment of nutritional requirements of cells for DNA damage prevention

(2010) C. F. Bull et al.   MUTAGENESIS

Molecular mechanisms of the origin of micronuclei from extrachromosomal elements

(2010) N. Shimizu   MUTAGENESIS

Live cell imaging of micronucleus formation and development

(2010) Manabu Yasui et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress

(2010) Koh-ichi Utani et al.   PLoS One

Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation

(2010) Joshua B Stevens et al.   Molecular Cytogenetics

The genome-centric concept: resynthesis of evolutionary theory

(2009) Henry H. Q. Heng   BIOESSAYS

Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer

(2009) Christine J. Ye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An in vitro micronucleus assay with size-classified micronucleus counting to discriminate aneugens from clastogens

(2009) Kiyohiro Hashimoto et al.   TOXICOLOGY IN VITRO

Reversibility of apoptosis in cancer cells

(2008) H L Tang et al.   BRITISH JOURNAL OF CANCER

The Conflict Between Complex Systems and Reductionism

(2008) Henry H. Q. Heng   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: The HUMN project perspective on current status and knowledge gaps

(2008) N HOLLAND et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Chromosomal mosaicism goes global

(2008) Ivan Y Iourov et al.   Molecular Cytogenetics