JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 46, Pages E6301-E6310
Publisher
Proceedings of the National Academy of Sciences
Online
2015-11-03
DOI
10.1073/pnas.1515386112
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors
- (2014) S. C. Meyer et al. CLINICAL CANCER RESEARCH
- Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
- (2014) Alberto Toso et al. Cell Reports
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
- (2013) Tamara Tchkonia et al. Cell Metabolism
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Proinflammatory Cytokines, Aging, and Age-Related Diseases
- (2013) Martin Michaud et al. Journal of the American Medical Directors Association
- A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans
- (2013) Jocelyne C. Whitehead et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis
- (2013) A Pardanani et al. LEUKEMIA
- Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
- (2012) Remi-Martin Laberge et al. AGING CELL
- A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis
- (2012) Srdan Verstovsek et al. NEW ENGLAND JOURNAL OF MEDICINE
- JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis
- (2012) Claire Harrison et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue
- (2011) C. N. Lumeng et al. JOURNAL OF IMMUNOLOGY
- Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)
- (2011) Kamran Ghoreschi et al. JOURNAL OF IMMUNOLOGY
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Long-Term Outcome of Treatment with Ruxolitinib in Myelofibrosis
- (2011) Ayalew Tefferi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Emerging roles of JAK–STAT signaling pathways in adipocytes
- (2011) Allison J. Richard et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Fat tissue, aging, and cellular senescence
- (2010) Tamara Tchkonia et al. AGING CELL
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
- (2010) A. Quintas-Cardama et al. BLOOD
- Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence
- (2010) A. Villaret et al. DIABETES
- Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
- (2010) J. S. Fridman et al. JOURNAL OF IMMUNOLOGY
- Aging, Depot Origin, and Preadipocyte Gene Expression
- (2010) Mark J. Cartwright et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
- (2010) Srdan Verstovsek et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen
- (2010) Jean-Philippe Coppé et al. PLoS One
- DNA damage response and cellular senescence in tissues of aging mice
- (2009) Chunfang Wang et al. AGING CELL
- Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
- (2009) A. J. Schetter et al. CARCINOGENESIS
- Janus kinases in immune cell signaling
- (2009) Kamran Ghoreschi et al. IMMUNOLOGICAL REVIEWS
- Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6
- (2009) M. E. Starr et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
- (2009) M Bryant Howren et al. PSYCHOSOMATIC MEDICINE
- Molecular inflammation: Underpinnings of aging and age-related diseases
- (2008) Hae Young Chung et al. AGEING RESEARCH REVIEWS
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search