Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

How to get to the other side of the mitochondrial inner membrane – the protein import motor

(2020) Dejana Mokranjac   BIOLOGICAL CHEMISTRY

Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence

(2020) Monika Barroso‐Vilares et al.   EMBO REPORTS

JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

(2019) Andrea Cosolo et al.   eLife

Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

(2019) Ricardo Aparicio et al.   Cell Reports

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

A genetically encoded fluorescent probe for imaging of oxygenation gradients in living Drosophila

(2018) Peter V. Lidsky et al.   DEVELOPMENT

Cellular Stress Associated with Aneuploidy

(2018) Jin Zhu et al.   DEVELOPMENTAL CELL

Basal mitophagy is widespread inDrosophilabut minimally affected by loss of Pink1 or parkin

(2018) Juliette J. Lee et al.   JOURNAL OF CELL BIOLOGY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant

(2018) Stacey A. Rimkus et al.   PLoS One

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

(2018) Joana Catarina Macedo et al.   Nature Communications

Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure

(2018) Stephan U. Gerlach et al.   Cell Reports

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

(2018) Najate Benhra et al.   DEVELOPMENTAL CELL

USP14 inhibition corrects an in vivo model of impaired mitophagy

(2018) Joy Chakraborty et al.   EMBO Molecular Medicine

Meddling with Fate: The Proteasomal Deubiquitinating Enzymes

(2017) Stefanie A.H. de Poot et al.   JOURNAL OF MOLECULAR BIOLOGY

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

eC-CLEM: flexible multidimensional registration software for correlative microscopies

(2017) Perrine Paul-Gilloteaux et al.   NATURE METHODS

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Feedback amplification loop drives malignant growth in epithelial tissues

(2017) Mariana Muzzopappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

(2017) Yasmin M. Ramdzan et al.   Cell Reports

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

(2017) Martin Borch Jensen et al.   eLife

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

(2016) Valentina Bouché et al.   Autophagy

Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase

(2016) Tomoyuki Sasaki et al.   Autophagy

Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis inDrosophila melanogaster

(2016) Emiliana Tognon et al.   Autophagy

Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis

(2016) Marta Clemente-Ruiz et al.   DEVELOPMENTAL CELL

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

(2016) Paul W Tillberg et al.   NATURE BIOTECHNOLOGY

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

(2016) Konstantina Rowald et al.   Cell Reports

In vivo genetic dissection of tumor growth and the Warburg effect

(2016) Cheng-Wei Wang et al.   eLife

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

(2015) Marcel Tiebe et al.   DEVELOPMENTAL CELL

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dosage Compensation inDrosophila

(2015) John C. Lucchesi et al.   Cold Spring Harbor Perspectives in Biology

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast

(2015) Genrikh V. Serpionov et al.   Scientific Reports

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

Tumor suppressor roles of CENP-E and Nsl1 inDrosophilaepithelial tissues

(2014) Marta Clemente-Ruiz et al.   CELL CYCLE

A NovelMitoTimerReporter Gene for Mitochondrial Content, Structure, Stress, and Damagein Vivo

(2014) Rhianna C. Laker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aneuploidy and tumorigenesis in Drosophila

(2014) Marco Milán et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fly-FUCCI: A Versatile Tool for Studying Cell Proliferation in Complex Tissues

(2014) Norman Zielke et al.   Cell Reports

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

(2013) Péter Lőw et al.   BMC CELL BIOLOGY

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition

(2013) Sara Morais da Silva et al.   JOURNAL OF CELL BIOLOGY

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Epithelial junctions maintain tissue architecture by directing planar spindle orientation

(2013) Yu-ichiro Nakajima et al.   NATURE

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of autophagy in cells with abnormal karyotype

(2012) Silvia Stingele et al.   Autophagy

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5

(2012) Yusuke Sekine et al.   MOLECULAR CELL

Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia

(2012) A. Dekanty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila

(2010) Sarah E. Siegrist et al.   CURRENT BIOLOGY

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

(2009) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY