Pyroptosis, metabolism, and tumor immune microenvironment

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

(2021) Ashley J. Russo et al.   NATURE IMMUNOLOGY

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy

(2021) Sheera R. Rosenbaum et al.   Cancer Discovery

Macrophage Responses to Environmental Stimuli During Homeostasis and Disease

(2021) Adil Rasheed et al.   ENDOCRINE REVIEWS

Genetics and Epigenetics in Asthma

(2021) Polyxeni Ntontsi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

(2021) Weiwei Xia et al.   Cell Death & Disease

Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

(2021) Haein An et al.   Cell Death & Disease

Metabolic Codependencies in the Tumor Microenvironment

(2021) Prasenjit Dey et al.   Cancer Discovery

A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets

(2021) Simranjeet Kaur et al.   Frontiers in Genetics

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

(2021) Sophie M. Poznanski et al.   Cell Metabolism

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis

(2021) Xiao He et al.   PHARMACOLOGICAL RESEARCH

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy

(2021) Xia Liu et al.   Science Translational Medicine

How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications

(2021) Heleen H. Van Acker et al.   TRENDS IN IMMUNOLOGY

Knocking ’em Dead: Pore-Forming Proteins in Immune Defense

(2020) Xing Liu et al.   Annual Review of Immunology

A review of cancer immunotherapy toxicity

(2020) Lucy Boyce Kennedy et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway

(2020) Jiao-Jiao Chen et al.   DNA AND CELL BIOLOGY

VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis

(2020) Yiyi Li et al.   EXPERIMENTAL CELL RESEARCH

Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci

(2020) Alexander D. Clark et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trimethylamine N‐oxide promotes apoE −/− mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

(2020) Peng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk

(2020) Mahmood Y. Hachim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunotherapeutic approaches for small-cell lung cancer

(2020) Wade T. Iams et al.   Nature Reviews Clinical Oncology

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis

(2020) Xing Zeng et al.   Nutrition & Metabolism

Caspase-11 promotes allergic airway inflammation

(2020) Zbigniew Zasłona et al.   Nature Communications

Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

(2020) Rafael Corrêa et al.   Frontiers in Immunology

Silencing of KCNQ1OT1 Decreases Oxidative Stress and Pyroptosis of Renal Tubular Epithelial Cells

(2020) Bei Zhu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

TLR4-mediated pyroptosis in human hepatoma-derived HuH-7 cells induced by a branched-chain polyunsaturated fatty acid, geranylgeranoic acid

(2020) Suemi Yabuta et al.   BIOSCIENCE REPORTS

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

TMEM173 Drives Lethal Coagulation in Sepsis

(2020) Hui Zhang et al.   Cell Host & Microbe

Mechanism and regulation of pyroptosis-mediated in cancer cell death

(2020) Jianwei Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors

(2020) Chenyang Han et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

(2020) Naroa Serna et al.   JOURNAL OF CONTROLLED RELEASE

Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells

(2020) Anne-Marie Madore et al.   Journal of Genetics and Genomics

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

(2020) Hayley I. Muendlein et al.   SCIENCE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

(2020) Lei Hu et al.   Cell Death & Disease

Role of GSDMB in Pyroptosis and Cancer

(2020) Lisha Li et al.   Cancer Management and Research

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

(2020) Felix Renaudin et al.   ANNALS OF THE RHEUMATIC DISEASES

Whole exome sequencing identified mutations causing hearing loss in five consanguineous Pakistani families

(2020) Yingjie Zhou et al.   BMC Medical Genetics

FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis

(2020) Zhaolin Zeng et al.   EXPERIMENTAL CELL RESEARCH

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Min Zheng et al.   IMMUNOLOGICAL REVIEWS

The Effect of Lycium barbarum Polysaccharides on Pyroptosis-Associated Amyloid β1-40 Oligomers-Induced Adult Retinal Pigment Epithelium 19 Cell Damage

(2020) Ming Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

(2020) Xingnan Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

(2020) Susanne Gaul et al.   JOURNAL OF HEPATOLOGY

Multiple roles of caspase‐8 in cell death, inflammation, and innate immunity

(2020) Pontus Orning et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis

(2020) Chengui Lu et al.   MOLECULAR IMMUNOLOGY

Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway

(2020) Mengyue Yang et al.   Oxidative Medicine and Cellular Longevity

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

(2020) Nathalia Moraes de Vasconcelos et al.   Cell Reports

Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma

(2020) Yunfeng Gao et al.   Nature Biomedical Engineering

Roles of HMGB1 in regulating myeloid-derived suppressor cells in the tumor microenvironment

(2020) Shuiling Jin et al.   Biomarker Research

BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice

(2020) Shuwen Qian et al.   Communications Biology

Mapping the 17q12-21.1 Locus for Variants Associated with Early-onset Asthma in African Americans

(2020) Hongsheng Gui et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk

(2020) Duo Liu et al.   CANCER RESEARCH

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

(2020) Tianlu Li et al.   Genome Medicine

Identification of Signatures of Prognosis Prediction for Melanoma Using a Hypoxia Score

(2020) Yanhong Shou et al.   Frontiers in Genetics

Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy

(2020) Qinghai Meng et al.   Journal of Advanced Research

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

(2020) Eun Hee Koh et al.   GUT

GSDME and its role in cancer: From behind the scenes to the front of the stage

(2020) Elke De Schutter et al.   INTERNATIONAL JOURNAL OF CANCER

Two GWAS-identified variants are associated with lumbar spinal stenosis and Gasdermin-C expression in Chinese population

(2020) Hua Jiang et al.   Scientific Reports

IL1β promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

(2020) Mate Kiss et al.   Cancer Immunology Research

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

(2019) Wenting Liao et al.   CANCER CELL

Intracellular delivery of an antibody targeting Gasdermin-B reduces HER2 breast cancer aggressiveness

(2019) Angela Molina-Crespo et al.   CLINICAL CANCER RESEARCH

Sorafenib Induces Pyroptosis in Macrophages and Triggers Natural Killer Cell–Mediated Cytotoxicity Against Hepatocellular Carcinoma

(2019) Carina Hage et al.   HEPATOLOGY

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

(2019) Jean Defourny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Butyrate Rather than LPS Subverts Gingival Epithelial Homeostasis by Downregulation of Intercellular Junctions and Triggering Pyroptosis

(2019) Juan Liu et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases

(2019) Na An et al.   Frontiers in Immunology

Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment

(2019) Suzanne Ostrand-Rosenberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

GSDMD is required for effector CD8+ T cell responses to lung cancer cells

(2019) Guangmin Xi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

(2019) Sheng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease

(2019) Youliang Wang et al.   Frontiers in Endocrinology

Sequence variants in genes causing nonsyndromic hearing loss in a Pakistani cohort

(2019) Amjad Khan et al.   Molecular Genetics & Genomic Medicine

Sodium butyrate alleviates high-glucose-induced renal glomerular endothelial cells damage via inhibiting pyroptosis

(2019) Junling Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis

(2019) Xianhui Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pyroptosis: A new frontier in cancer

(2019) Yuan Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway

(2019) Yang Liu et al.   BMC Cardiovascular Disorders

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

lncRNA GAS5/miR-452-5p Reduces Oxidative Stress and Pyroptosis of High-Glucose-Stimulated Renal Tubular Cells

(2019) Cuisong Xie et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Changes in macrophage transcriptome associate with systemic sclerosis and mediateGSDMAcontribution to disease risk

(2018) Aida Moreno-Moral et al.   ANNALS OF THE RHEUMATIC DISEASES

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Atherosclerosis and inflammation: overview and updates

(2018) Glaucylara Reis Geovanini et al.   CLINICAL SCIENCE

Gasdermin D Flashes an Exit Signal for IL-1

(2018) Teneema Kuriakose et al.   IMMUNITY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

(2018) Ronald A. Panganiban et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways

(2018) Novi Kusumaningrum et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of colon cancer with liver X receptor agonists induces immunogenic cell death

(2018) Qiang Wang et al.   MOLECULAR CARCINOGENESIS

Digital signaling network drives the assembly of the AIM2-ASC inflammasome

(2018) Mariusz Matyszewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

(2018) Nathalia Pizato et al.   Scientific Reports

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

(2018) Joselyn Rojas et al.   Journal of Diabetes Research

Interleukin-1 Beta—A Friend or Foe in Malignancies?

(2018) Rebekka Bent et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Efferocytosis in the tumor microenvironment

(2018) Thomas A. Werfel et al.   Seminars in Immunopathology

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

(2018) Aakanksha Jain et al.   Nature Communications

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

(2018) Pradeep Suri et al.   PLoS Genetics

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Role of pyroptosis in cardiovascular disease

(2018) Zeng Zhaolin et al.   CELL PROLIFERATION

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Cell death pathologies: targeting death pathways and the immune system for cancer therapy

(2018) Francesca Pentimalli et al.   GENES AND IMMUNITY

Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes

(2018) Koumei Shirasuna et al.   JOURNAL OF CELLULAR PHYSIOLOGY

OxLDL induces vascular endothelial cell pyroptosis through miR‐125a‐5p/TET2 pathway

(2018) Zeng Zhaolin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

(2018) Jianqiu Xiao et al.   PLOS BIOLOGY

NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development

(2018) Patricia Ahechu et al.   Frontiers in Immunology

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

The NLRC4 Inflammasome

(2017) Joseph A. Duncan et al.   IMMUNOLOGICAL REVIEWS

Homozygous mutations in PJVK and MYO15A genes associated with non-syndromic hearing loss in Moroccan families

(2017) Sara Salime et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner

(2017) Marcin Kazmierczak et al.   JOURNAL OF NEUROSCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice

(2017) Suzan L. Harris et al.   NEUROSCIENCE

Autoimmune disease variants regulateGSDMBgene expression in human immune cells and whole blood

(2017) Yang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

(2017) Kinlin L. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation

(2017) Gyda Bjornsdottir et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

SOCS2 overexpression alleviates diabetic nephropathy in rats by inhibiting the TLR4/NF-κB pathway

(2017) Suxia Yang et al.   Oncotarget

Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release

(2016) Nicolas J. Pillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial CellsNovelty and Significance

(2016) Hang Xi et al.   CIRCULATION RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation

(2016) Neil M. Iyengar et al.   JOURNAL OF CLINICAL ONCOLOGY

High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy

(2016) Katherine H. Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

(2016) Aiyun Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular study of patients with auditory neuropathy

(2016) GUILHERME MACHADO DE CARVALHO et al.   Molecular Medicine Reports

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis

(2016) Y. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy for lung cancer

(2016) Antonius Steven et al.   RESPIROLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer

(2016) Marta Hergueta-Redondo et al.   Oncotarget

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

(2016) Masashi Miguchi et al.   PLoS One

Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis

(2016) Yanfei Zhang et al.   Scientific Reports

Structural Biology of Innate Immunity

(2015) Qian Yin et al.   Annual Review of Immunology

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GSDMfamily genes meet autophagy

(2015) Masaru Tamura et al.   BIOCHEMICAL JOURNAL

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

(2015) Sedigheh Delmaghani et al.   CELL

Gasdermin D: the long-awaited executioner of pyroptosis

(2015) Si Ming Man et al.   CELL RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying Children With Poor Cochlear Implantation Outcomes Using Massively Parallel Sequencing

(2015) Chen-Chi Wu et al.   MEDICINE

Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury

(2015) Miaomiao Wei et al.   MOLECULAR IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Regulated necrosis and its implications in toxicology

(2015) Toshihiko Aki et al.   TOXICOLOGY

DFNA5, a Gene Involved in Hearing Loss and Cancer: A Review

(2014) Ken Op de Beeck et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

HMGB1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells

(2014) K. H. Parker et al.   CANCER RESEARCH

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome

(2014) Meijun Du et al.   HUMAN MOLECULAR GENETICS

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells

(2014) Marta Hergueta-Redondo et al.   PLoS One

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

Expression of GSDML Associates with Tumor Progression in Uterine Cervix Cancer

(2014) Qiao Sun et al.   Translational Oncology

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy

(2014) X Li et al.   Cell Death & Disease

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

Genetic variation associated with circulating monocyte count in the eMERGE Network

(2013) David R. Crosslin et al.   HUMAN MOLECULAR GENETICS

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Caspase-1: The inflammasome and beyond

(2013) Gabriel Sollberger et al.   Innate Immunity

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages

(2013) Qiang Wang et al.   INTERNATIONAL IMMUNOLOGY

IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

(2013) Shlomo Z. Ben-Sasson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis

(2013) Antonio Giordano et al.   JOURNAL OF LIPID RESEARCH

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma

(2013) Minal Çalışkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

A p.C343S missense mutation in PJVK causes progressive hearing loss

(2012) Ghulam Mujtaba et al.   GENE

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes

(2012) Katja Christodoulou et al.   GUT

Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes

(2012) Mingxing Lei et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Gsdma3I359N is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis

(2012) Sudhir Kumar et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Role of sulfatide in normal and pathological cells and tissues

(2012) Tadanobu Takahashi et al.   JOURNAL OF LIPID RESEARCH

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

(2012) Clare M. Reynolds et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

(2012) Ke Hao et al.   PLoS Genetics

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

High frequency of autosomal-recessive DFNB59 hearing loss in an isolated Arab population in Israel

(2011) G Borck et al.   CLINICAL GENETICS

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

(2011) Nada M. Saleh et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Linking the inflammasome to obesity-related disease

(2011) Tiffany Horng et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR

(2011) Jinho Yu et al.   PEDIATRIC PULMONOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease

(2009) Dominique J. Verlaan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium

(2008) Norihisa Saeki et al.   GENES CHROMOSOMES & CANCER

Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development

(2008) Tomoaki Fujii et al.   GENESIS

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY

Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues

(2007) Stacy Carl-McGrath et al.   PATHOLOGY