Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Inflammasomes contributing to inflammation in arthritis

(2020) Lotte Spel et al.   IMMUNOLOGICAL REVIEWS

Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

(2020) Zhaodi Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis

(2020) Si Wen et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

(2020) Xiaowen Yu et al.   Science Translational Medicine

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

(2019) Mengjiao Wu et al.   EBioMedicine

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects

(2019) Takaya Tajima et al.   KIDNEY INTERNATIONAL

Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells

(2019) Xin Chou et al.   ARCHIVES OF TOXICOLOGY

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression

(2019) Jun Ni et al.   Cell Death & Disease

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Caspase-3-mediated GSDME activation contributes to cisplatin- and doxorubicin-induced secondary necrosis in mouse macrophages

(2019) Feng-Yi Mai et al.   CELL PROLIFERATION

Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury

(2019) Zhiming Ye et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Gasdermins and their role in immunity and inflammation

(2019) Pontus Orning et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

(2019) Xinbin Zheng et al.   LIFE SCIENCES

Amniotic fluid stem cells ameliorate cisplatin-induced acute renal failure through induction of autophagy and inhibition of apoptosis

(2019) Ekta Minocha et al.   Stem Cell Research & Therapy

Exonic mutations and exon skipping: Lessons learned from DFNA5

(2018) Kevin T. Booth et al.   HUMAN MUTATION

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure

(2018) Emily J. See et al.   KIDNEY INTERNATIONAL

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system

(2016) Seamus J. Martin   FEBS Journal

Erratum: Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology

(2015) Ravindra L Mehta et al.   LANCET

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity

(2013) Md. Abdul Hye Khan et al.   FASEB JOURNAL

Acute kidney injury: an increasing global concern

(2013) Norbert H Lameire et al.   LANCET

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

(2012) Shue Dong Chung et al.   PLoS One

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE