Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

(2018) Monica L. Gonzalez Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

(2017) Danielle P. A. Mascarenhas et al.   PLoS Pathogens

The intersection of cell death and inflammasome activation

(2016) James E. Vince et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Manipulation of Interleukin-1β and Interleukin-18 Production byYersinia pestisEffectors YopJ and YopM and Redundant Impact on Virulence

(2016) Dmitry Ratner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Extrinsic TNF Collaborates with TRIF Signaling To PromoteYersinia-Induced Apoptosis

(2016) Lance W. Peterson et al.   JOURNAL OF IMMUNOLOGY

Bacterial secretion systems and regulation of inflammasome activation

(2016) Dmitry Ratner et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex

(2014) X. Lei et al.   JOURNAL OF VIROLOGY

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

(2014) John G Doench et al.   NATURE BIOTECHNOLOGY

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

A Vibrio parahaemolyticus T3SS Effector Mediates Pathogenesis by Independently Enabling Intestinal Colonization and Inhibiting TAK1 Activation

(2013) Xiaohui Zhou et al.   Cell Reports

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

(2012) Ulrich Meinzer et al.   Cell Host & Microbe

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

(2011) Ying Zheng et al.   PLoS Pathogens

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

YopJ-Promoted Cytotoxicity and Systemic Colonization Are Associated with High Levels of Murine Interleukin-18, Gamma Interferon, and Neutrophils in a Live Vaccine Model of Yersinia pseudotuberculosis Infection

(2010) Y. Zhang et al.   INFECTION AND IMMUNITY