Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

(2019) Xi-Chun Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

(2019) Rebecca Ward et al.   PHARMACOLOGICAL RESEARCH

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation

(2018) Penghao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aucubin protects against pressure overload-induced cardiac remodelling via the β3 -adrenoceptor-neuronal NOS cascades

(2018) Qing-Qing Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Correction to: Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018)   CIRCULATION

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

(2018) Chunxia Yao et al.   CIRCULATION

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

sRAGE attenuates angiotensin II-induced cardiomyocyte hypertrophy by inhibiting RAGE-NFκB-NLRP3 activation

(2018) Soyeon Lim et al.   INFLAMMATION RESEARCH

Cardioprotective Role of Colchicine Against Inflammatory Injury in a Rat Model of Acute Myocardial Infarction

(2018) Oussama Bakhta et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia

(2018) Mengyu Lai et al.   Frontiers in Aging Neuroscience

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries

(2018) Xinxu Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice

(2018) Chao Liu et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-495 Ameliorates Cardiac Microvascular Endothelial Cell Injury and Inflammatory Reaction by Suppressing the NLRP3 Inflammasome Signaling Pathway

(2018) Tao  Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NLRP3 deficiency accelerates pressure overload-induced cardiac remodeling via increased TLR4 expression

(2018) Fangfang Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

(2018) Wei-Ting Wong et al.   Frontiers in Immunology

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms

(2018) Xinyu Yang et al.   Frontiers in Pharmacology

Statin protects the heart against ischemia-reperfusion injury via inhibition of the NLRP3 inflammasome

(2017) Si-yang Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

P2X7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL-1β pathway

(2017) Jie Yin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-1 Beta as a Target for Atherosclerosis Therapy

(2017) Peter Libby   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction

(2017) Luís E. Pavillard et al.   Oncotarget

Andrographolide Protects against Aortic Banding-Induced Experimental Cardiac Hypertrophy by Inhibiting MAPKs Signaling

(2017) Qing Q. Wu et al.   Frontiers in Pharmacology

Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies

(2017) Xinyu Yang et al.   Frontiers in Physiology

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

(2016) Gerardus P.J. van Hout et al.   EUROPEAN HEART JOURNAL

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse

(2016) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis

(2016) Swati Iyer et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

(2016) Gustavo Monnerat et al.   Nature Communications

Aging-associated oxidized albumin promotes cellular senescence and endothelial damage

(2016) Matilde Alique et al.   Clinical Interventions in Aging

Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy

(2016) Yuan-Yuan Ding et al.   Frontiers in Pharmacology

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiovascular Pathobiology of Inflammasomes: Inflammatory Machinery and Beyond

(2015) Pin-Lan Li   ANTIOXIDANTS & REDOX SIGNALING

The Inflammasome in Myocardial Injury and Cardiac Remodeling

(2015) Stefano Toldo et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis

(2015) Sachiko Bando et al.   ATHEROSCLEROSIS

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

(2015) Wenxiu Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

(2015) Ying-Cing Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

(2015) Borja Ibáñez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling

(2015) Victor P. Long et al.   LIFE SCIENCES

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Contributions of risk factors and medical care to cardiovascular mortality trends

(2015) Majid Ezzati et al.   Nature Reviews Cardiology

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

(2014) Wenjie Guo et al.   Autophagy

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac fibroblasts support cardiac inflammation in heart failure

(2014) Diana Lindner et al.   BASIC RESEARCH IN CARDIOLOGY

NLRP3 Inflammasome as a Novel Player in Myocardial Infarction

(2014) Masafumi Takahashi   International Heart Journal

Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression

(2014) Willeke M.C. Jong et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Interleukin-1β Reduces L-type Ca2+Current through Protein Kinase Cϵ Activation in Mouse Heart

(2014) Nabil El Khoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate-Stimulated Monocytes Induce Adhesion Molecule Expression in Endothelial Cells via IL-1 Signaling Pathway

(2014) Yosuke Shikama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death

(2014) Tadashi Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Resveratrol and its metabolites modulate cytokine-mediated induction of eotaxin-1 in human pulmonary artery endothelial cells

(2013) Joseph M. Wu et al.   Annals of the New York Academy of Sciences

Pirfenidone Attenuates Cardiac Fibrosis in a Mouse Model of TAC-Induced Left Ventricular Remodeling by Suppressing NLRP3 Inflammasome Formation

(2013) Yongliang Wang et al.   CARDIOLOGY

NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin

(2013) Mamoru Satoh et al.   CLINICAL SCIENCE

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy

(2013) Peter Libby   NEW ENGLAND JOURNAL OF MEDICINE

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Hypoxic preconditioning protects microvascular endothelial cells against hypoxia/reoxygenation injury by attenuating endoplasmic reticulum stress

(2012) Xu-Dong Wu et al.   APOPTOSIS

Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

(2012) Jessica Gage et al.   CANADIAN JOURNAL OF CARDIOLOGY

Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome

(2012) Jia He et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Colchicine Use Is Associated with Decreased Prevalence of Myocardial Infarction in Patients with Gout

(2012) DARIA B. CRITTENDEN et al.   JOURNAL OF RHEUMATOLOGY

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

(2012) Stefan M. Nidorf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer

(2012) Jianbiao Zhou et al.   MITOCHONDRION

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α

(2011) Yehuda Kamari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammasome Activation in Reperfusion Injury

(2011) Sebastian Grundmann et al.   CIRCULATION

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNA changes in human arterial endothelial cells with senescence: Relation to apoptosis, eNOS and inflammation

(2011) Catarina Rippe et al.   EXPERIMENTAL GERONTOLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Icariside II Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression Coupled with the ERK, Akt and JNK Signaling Pathways

(2011) Jing Gu et al.   MOLECULES

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms

(2010) Jon R. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells

(2010) Jinchun Qian et al.   JOURNAL OF ETHNOPHARMACOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY