Caspase-1: The inflammasome and beyond

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β

(2012) Hella Luksch et al.   HUMAN MUTATION

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

(2012) Anwari Akhter et al.   IMMUNITY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-4 Is Required for Activation of Inflammasomes

(2012) G. Sollberger et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

(2012) Süheda Erener et al.   MOLECULAR CELL

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes in Intestinal Inflammation and Cancer

(2011) Grace Y. Chen et al.   GASTROENTEROLOGY

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome

(2011) Katherine Labbé et al.   IMMUNITY

Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage

(2011) Syed Raza Ali et al.   IMMUNITY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent Nuclear Factor κB Signaling

(2011) Kristof Kersse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme

(2011) John G. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Regulation of NF-κB signaling by caspases and MALT1 paracaspase

(2010) Jens Staal et al.   CELL RESEARCH

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Inflammatory Caspases in Innate Immunity and Inflammation

(2010) Amir S. Yazdi et al.   Journal of Innate Immunity

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: a broad role in unconventional protein secretion?

(2010) Ravi Manjithaya et al.   TRENDS IN CELL BIOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

(2009) Kate Schroder et al.   CURRENT BIOLOGY

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b

(2009) Jill K. Terra et al.   JOURNAL OF IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Autoinflammatory Disease Due to Homozygous Deletion of theIL1RNLocus

(2009) Sreelatha Reddy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Caspase-14 reveals its secrets

(2008) Geertrui Denecker et al.   JOURNAL OF CELL BIOLOGY

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE

Confinement of caspase-12 proteolytic activity to autoprocessing

(2008) S. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA