Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy

Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy

(2020) Xia Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

(2019) Chang Liu et al.   IMMUNITY

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

(2019) Yangjing Zhao et al.   Cellular & Molecular Immunology

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy

(2018) Lan Huang et al.   Cellular & Molecular Immunology

Nanoliposomal delivery of cytosolic phospholipase A 2 inhibitor arachidonyl trimethyl ketone for melanoma treatment

(2018) Raghavendra Gowda et al.   Nanomedicine-Nanotechnology Biology and Medicine

Metabolic Control of CD8 + T Cell Fate Decisions and Antitumor Immunity

(2018) Lianjun Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

(2018) Xia Liu et al.   Nature Communications

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

(2018) Lingyun Li et al.   Cell Metabolism

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

(2017) Soumaya Kouidhi et al.   Frontiers in Immunology

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells

(2015) Shin-ichiro Takebayashi et al.   AGING CELL

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Nutrient Competition: A New Axis of Tumor Immunosuppression

(2015) Madhusudhanan Sukumar et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

(2015) Ende Zhao et al.   NATURE IMMUNOLOGY

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Metabolic control of regulatory T cell development and function

(2015) Hu Zeng et al.   TRENDS IN IMMUNOLOGY

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy

(2015) Jian Ye et al.   OncoImmunology

Phospholipase A2 regulation of lipid droplet formation

(2014) Carlos Guijas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dividing Cells Regulate Their Lipid Composition and Localization

(2014) G. Ekin Atilla-Gokcumen et al.   CELL

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence

(2014) J. Ye et al.   EMBO Molecular Medicine

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Radiation induces senescence and a bystander effect through metabolic alterations

(2014) E-C Liao et al.   Cell Death & Disease

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Tumor-Derived    Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

(2013) J. Ye et al.   JOURNAL OF IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Phospholipids and lipid droplets

(2012) Anke Penno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Human regulatory T cells induce T-lymphocyte senescence

(2012) J. Ye et al.   BLOOD

Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes

(2012) Carlos Guijas et al.   JOURNAL OF LIPID RESEARCH

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Use of BODIPY (493/503) to Visualize Intramuscular Lipid Droplets in Skeletal Muscle

(2011) Espen E. Spangenburg et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Electrospray Ionization Tandem Mass Spectrometry of Sodiated Adducts of Cholesteryl Esters

(2011) John A. Bowden et al.   LIPIDS

Not Just Fat: The Structure and Function of the Lipid Droplet

(2011) T. Fujimoto et al.   Cold Spring Harbor Perspectives in Biology

Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging

(2010) Judith H. Ford   AGE

Transduction of Tumor-Specific T Cells with CXCR2 Chemokine Receptor Improves Migration to Tumor and Antitumor Immune Responses

(2010) W. Peng et al.   CLINICAL CANCER RESEARCH

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Lipid Droplet Biogenesis Induced by Stress Involves Triacylglycerol Synthesis That Depends on Group VIA Phospholipase A2

(2009) Albert Gubern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-Cell Receptor Gene Therapy of Established Tumors in a Murine Melanoma Model

(2009) John D. Abad et al.   JOURNAL OF IMMUNOTHERAPY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Group IVA Phospholipase A2Is Necessary for the Biogenesis of Lipid Droplets

(2008) Albert Gubern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY