Interleukin-1 Beta—A Friend or Foe in Malignancies?

Diverse exocytic pathways for mast cell mediators

(2018) Hao Xu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NLRP3 promotes tumor growth and metastasis in human oral squamous cell carcinoma

(2018) Han Wang et al.   BMC CANCER

Targeting myeloid-derived suppressor cells for cancer immunotherapy

(2018) Yijun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real-life clinical practice: a nationwide multicenter retrospective observational study

(2018) Jurgen Sota et al.   CLINICAL RHEUMATOLOGY

Multi-omic molecular profiling of lung cancer in COPD

(2018) Brian J. Sandri et al.   EUROPEAN RESPIRATORY JOURNAL

A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells

(2018) Gao Yi et al.   INFLAMMATION RESEARCH

Heterogeneity in Immune Cell Content in Malignant Pleural Mesothelioma

(2018) Jorien Minnema-Luiting et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gain of function mutation and inflammasome driven diseases in human and mouse models

(2018) Mario D. Cordero et al.   JOURNAL OF AUTOIMMUNITY

Biochemical and molecular study on interleukin-1β gene expression and relation of single nucleotide polymorphism in promoter region with Type 2 diabetes mellitus

(2018) Safaa I. Tayel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF -mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial

(2018) Reinhard Dummer et al.   LANCET ONCOLOGY

Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis

(2018) Yu-Lei Gao et al.   MEDIATORS OF INFLAMMATION

Inflammasome biology, molecular pathology and therapeutic implications

(2018) Fawaz Awad et al.   PHARMACOLOGY & THERAPEUTICS

Cancer Associated Fibroblasts: The Architects of Stroma Remodeling

(2018) Alice Santi et al.   PROTEOMICS

Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer

(2018) Jennifer L. Steel et al.   PSYCHOSOMATIC MEDICINE

Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma

(2018) Naofumi Mukaida et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cellular immunotherapy as a therapeutic approach in multiple myeloma

(2018) Jessica Liegel et al.   Expert Review of Hematology

BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells

(2018) Eva Hajek et al.   Oncotarget

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

(2018) Xinglong Qu et al.   Frontiers in Immunology

The diversity of circulating neutrophils in cancer

(2017) Inbal Mishalian et al.   IMMUNOBIOLOGY

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

(2017) Alberto Mantovani et al.   IMMUNOLOGICAL REVIEWS

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

The family of the interleukin-1 receptors

(2017) Diana Boraschi et al.   IMMUNOLOGICAL REVIEWS

Recruited monocytic myeloid-derived suppressor cells promote the arrest of tumor cells in the premetastatic niche through an IL-1β-mediated increase in E-selectin expression

(2017) Huifang Shi et al.   INTERNATIONAL JOURNAL OF CANCER

Post-Translational Modifications of the TAK1-TAB Complex

(2017) Yusuke Hirata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

(2017) Helen L. Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

(2017) Martina B. Lorey et al.   MOLECULAR & CELLULAR PROTEOMICS

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain

(2017) Min Jia et al.   Molecular Pain

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

(2017) Sam Strickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins

(2017) Abhishek K. Singh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System

(2017) Deepti Pilli et al.   Frontiers in Immunology

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

(2017) Fawaz Awad et al.   PLoS One

Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma

(2016) John A. Lust et al.   AMERICAN JOURNAL OF HEMATOLOGY

Intracellular interleukin (IL)-1 family cytokine processing enzyme

(2016) Areum Kwak et al.   ARCHIVES OF PHARMACAL RESEARCH

MDSCs in cancer: Conceiving new prognostic and therapeutic targets

(2016) Francesco De Sanctis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy

(2016) Michal Baniyash   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-associated macrophages and anti-tumor therapies: complex links

(2016) Cristina Belgiovine et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders

(2016) Faisal Aziz   CELLULAR IMMUNOLOGY

Association of IL1Β (-511 A/C) and IL6 (-174 G > C) polymorphisms with higher disease activity and clinical pattern of psoriatic arthritis

(2016) N. Cubino et al.   CLINICAL RHEUMATOLOGY

E2F1 and NF-?B: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets

(2016) Yulin Huang et al.   CURRENT CANCER DRUG TARGETS

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

New roles for CD14 and IL-β linking inflammatory dendritic cells to IL-17 production in memory CD4+ T cells

(2016) Juan M Ilarregui et al.   IMMUNOLOGY AND CELL BIOLOGY

Helicobacter pylori Infection Synergistic with IL-1β Gene Polymorphisms Potentially Contributes to the Carcinogenesis of Gastric Cancer

(2016) Jun-Bo Hong et al.   International Journal of Medical Sciences

Lipopolysaccharide and IL-1β coordinate a synergy on cytokine production by upregulating MyD88 expression in human gingival fibroblasts

(2016) Colleen W. Brinson et al.   MOLECULAR IMMUNOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome in kidney disease and autoimmunity

(2016) Holly L Hutton et al.   NEPHROLOGY

Pyrexia in dabrafenib-treated melanoma patients is not associated with common genetic variation or HLA polymorphisms

(2016) Diptee Kulkarni et al.   PHARMACOGENOMICS

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Interleukin-1β increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model

(2016) FUNG-YU HUANG et al.   Oncology Letters

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

Regulatory T Cells: Differentiation and Function

(2016) G. Plitas et al.   Cancer Immunology Research

CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma

(2016) Guang-Tao Yu et al.   OncoImmunology

LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma

(2016) Wei-Wei Deng et al.   OncoImmunology

GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

(2016) Paola De Marco et al.   Scientific Reports

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

(2016) Beichu Guo et al.   Scientific Reports

The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold

(2016) Anthony C. G. Dossang et al.   Scientific Reports

Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways

(2015) Kannan Badri Narayanan et al.   APOPTOSIS

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Interleukin-1 as a therapeutic target in gout

(2015) Alexandre Dumusc et al.   CURRENT OPINION IN RHEUMATOLOGY

The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases

(2015) Jennifer Palomo et al.   CYTOKINE

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Myeloid regulatory cells in tumor spreading and metastasis

(2015) Anton A. Keskinov et al.   IMMUNOBIOLOGY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

(2015) Hatem Alfakry et al.   Innate Immunity

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin E2Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

(2015) Milena Sokolowska et al.   JOURNAL OF IMMUNOLOGY

IL-1 Receptor Type 2 Suppresses Collagen-Induced Arthritis by Inhibiting IL-1 Signal on Macrophages

(2015) Kenji Shimizu et al.   JOURNAL OF IMMUNOLOGY

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Blocking IL1  Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis

(2015) T. Voloshin et al.   MOLECULAR CANCER THERAPEUTICS

Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis

(2015) R Mora-Buch et al.   Mucosal Immunology

Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts

(2015) Yali Han et al.   TUMOR BIOLOGY

Interleukin-1 and acute brain injury

(2015) Katie N. Murray et al.   Frontiers in Cellular Neuroscience

Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells

(2015) Ole Audun Werner Haabeth et al.   OncoImmunology

NLRP3 Mediates NF-κB Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation

(2015) Takeshi Kinoshita et al.   PLoS One

Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma

(2015) Catherine Westbom et al.   PLoS One

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Interleukin-1β Promotes Ovarian Tumorigenesis through a p53/NF-κB-Mediated Inflammatory Response in Stromal Fibroblasts

(2015) Isaiah Gregory Schauer et al.   NEOPLASIA

A Functional Synonymous Coding Variant in theIL1RNGene Is Associated with Survival in Septic Shock

(2014) Nuala J. Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Genetic Polymorphism of Interleukin-1A (IL-1A), IL-1B, and IL-1 Receptor Antagonist (IL-1RN) and Prostate Cancer Risk

(2014) Hua Xu et al.   Asian Pacific Journal of Cancer Prevention

The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS): A study using cytokine receptor-deficient mice

(2014) Logan B. Smith et al.   BRAIN BEHAVIOR AND IMMUNITY

Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs

(2014) John Wong et al.   CANCER BIOLOGY & THERAPY

Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14+ cells from patients with rheumatoid arthritis

(2014) Dorota Trzybulska et al.   CELLULAR IMMUNOLOGY

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients

(2014) Huanhuan Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Interleukin-1 blockade in rheumatoid arthritis and heart failure: A missed opportunity?

(2014) Antonio Abbate et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1β Production

(2014) Kuo-Feng Hua et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An inherited mutation inNLRC4causes autoinflammation in human and mice

(2014) Akiko Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF- -Induced Foxp3 Expression

(2014) S. Ikeda et al.   JOURNAL OF IMMUNOLOGY

Unknown

(2014) Charles Dinarello   MOLECULAR MEDICINE

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

A pan caspase inhibitor decreases caspase-1, IL-1αand IL-1β, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules

(2014) Dong Won Lee et al.   RENAL FAILURE

P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3

(2014) Yuanyuan Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility

(2014) Guoliang Zhang et al.   PLoS Pathogens

Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

(2013) Neta Erez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association ofNLRP1genetic variants and mRNA overexpression with generalized vitiligo and disease activity in a Gujarat population

(2013) M. Dwivedi et al.   BRITISH JOURNAL OF DERMATOLOGY

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin

(2013) John Wong et al.   CANCER BIOLOGY & THERAPY

Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

(2013) Yasuyuki Shigematsu et al.   CANCER LETTERS

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1−/−) mice

(2013) Fung-Yu Huang et al.   EUROPEAN JOURNAL OF CANCER

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Tumor associated macrophages and neutrophils in cancer

(2013) Maria Rosaria Galdiero et al.   IMMUNOBIOLOGY

Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells

(2013) Mirjam Schenk et al.   IMMUNOLOGY

The Role of IL-1  in the Early Tumor Cell-Induced Angiogenic Response

(2013) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1  via Caspase-8 in Dendritic Cells

(2013) C. Antonopoulos et al.   JOURNAL OF IMMUNOLOGY

Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions

(2013) Praxedis Martin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

NF-κB-Dependent Role for Cold-Inducible RNA Binding Protein in Regulating Interleukin 1β

(2013) Christian Brochu et al.   PLoS One

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Treating inflammation by blocking interleukin-1 in humans

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

Chemotherapeutic Targeting of Cell Death Pathways

(2012) Sylvia Mansilla et al.   Anti-Cancer Agents in Medicinal Chemistry

IL-1 receptor 2 (IL-1R2) and its role in immune regulation

(2012) Vanessa A. Peters et al.   BRAIN BEHAVIOR AND IMMUNITY

How biologics targeting the IL-1 system are being considered for the treatment of type 2 diabetes

(2012) Marianne Böni-Schnetzler et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Helical assembly in the death domain (DD) superfamily

(2012) Ryan Ferrao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II

(2012) Inken Lorenzen et al.   FEBS LETTERS

Krüppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages

(2012) Junwen Liu et al.   FEBS LETTERS

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

(2012) Joannes FM Jacobs et al.   LANCET ONCOLOGY

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular characterization of a cancer-related single nucleotide polymorphism in the pro-inflammatory interleukin-1B gene

(2012) N.E. Landvik et al.   MOLECULAR CARCINOGENESIS

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis

(2012) Ying Zhang et al.   PLoS One

New insights into chronic inflammation-induced immunosuppression

(2012) Julia Kanterman et al.   SEMINARS IN CANCER BIOLOGY

NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese

(2011) Jiangdong Sui et al.   ARTHRITIS AND RHEUMATISM

Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

(2011) Kristin A. D. Sauter et al.   CANCER BIOLOGY & THERAPY

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients

(2011) Paola Filipazzi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

Cyst Fluid Interleukin-1β (IL1β) Levels Predict the Risk of Carcinoma in Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2011) Ajay V. Maker et al.   CLINICAL CANCER RESEARCH

Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

(2011) C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

(2011) Ole Audun Werner Haabeth et al.   Nature Communications

Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling

(2010) W Zhou et al.   BRITISH JOURNAL OF CANCER

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immature Immunosuppressive CD14+HLA-DR−/low Cells in Melanoma Patients Are Stat3hi and Overexpress CD80, CD83, and DC-Sign

(2010) Isabel Poschke et al.   CANCER RESEARCH

New plays in the p53 theater

(2010) Yael Aylon et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis

(2010) Barbara K. Yoza et al.   CYTOKINE

Changes in chromatin structure and methylation of the human interleukin-1β gene during monopoiesis

(2010) Inga Wessels et al.   IMMUNOLOGY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment

(2009) M. SHERMAN   CLEVELAND CLINIC JOURNAL OF MEDICINE

Interleukin 1 regulates its own receptors in human endometrial cells via distinct mechanisms

(2009) C. Bellehumeur et al.   HUMAN REPRODUCTION

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Role for c-Rel and C/EBP /  in TLR-Mediated Induction of Proinflammatory Cytokines

(2009) Y.-C. Lu et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells

(2009) Matthias Bros et al.   MOLECULAR IMMUNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Alternate Splicing of Interleukin-1 Receptor Type II (IL1R2) In Vitro Correlates with Clinical Glucocorticoid Responsiveness in Patients with AIED

(2009) Andrea Vambutas et al.   PLoS One

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

(2009) H. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes

(2009) Andreas Lingel et al.   STRUCTURE

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

Cathepsin G is differentially expressed in primary human antigen-presenting cells

(2008) Christina Stoeckle et al.   CELLULAR IMMUNOLOGY

Is interleukin-1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?

(2008) Ron N. Apte et al.   IMMUNOLOGICAL REVIEWS

TRAF6 Autoubiquitination-Independent Activation of the NFκB and MAPK Pathways in Response to IL-1 and RANKL

(2008) Matthew C. Walsh et al.   PLoS One

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

(2007) Alban Ordureau et al.   BIOCHEMICAL JOURNAL