Organoid Technology: A Reliable Developmental Biology Tool for Organ-Specific Nanotoxicity Evaluation
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Title
Organoid Technology: A Reliable Developmental Biology Tool for Organ-Specific Nanotoxicity Evaluation
Authors
Keywords
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Journal
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-09-23
DOI
10.3389/fcell.2021.696668
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Note: Only part of the references are listed.- Patient-derived organoid (PDO) platforms to facilitate clinical decision making
- (2021) Lisa Liu et al. Journal of Translational Medicine
- Skin organoids: A new human model for developmental and translational research
- (2021) Jiyoon Lee et al. EXPERIMENTAL DERMATOLOGY
- Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids
- (2021) Gianluca Costamagna et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels
- (2021) Andrew C. Daly et al. Nature Communications
- Lung organoids, useful tools for investigating epithelial repair after lung injury
- (2021) Jing Kong et al. Stem Cell Research & Therapy
- Engineering organoids
- (2021) Moritz Hofer et al. Nature Reviews Materials
- Organoid and Spheroid Tumor Models: Techniques and Applications
- (2021) Sreenivasulu Gunti et al. Cancers
- Microfluidic Organoids-on-a-Chip: Quantum Leap in Cancer Research
- (2021) Fahriye Duzagac et al. Cancers
- From Clones to Buds and Branches: The Use of Lung Organoids to Model Branching Morphogenesis Ex Vivo
- (2021) Ana Ivonne Vazquez-Armendariz et al. Frontiers in Cell and Developmental Biology
- Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine
- (2021) Murali Kumarasamy et al. iScience
- Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing
- (2021) Hung-Jin Huang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Liver Organoids: Recent Developments, Limitations and Potential
- (2021) Sean Philip Harrison et al. Frontiers in Medicine
- Developing liver organoids from induced pluripotent stem cells (iPSCs): An alternative source of organoid generation for liver cancer research
- (2021) Romario Nguyen et al. CANCER LETTERS
- Nanomaterial Databases: Data Sources for Promoting Design and Risk Assessment of Nanomaterials
- (2021) Zuowei Ji et al. Nanomaterials
- Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity
- (2021) Rick Xing Ze Lu et al. Bioactive Materials
- One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure
- (2020) Zheng Ao et al. ANALYTICAL CHEMISTRY
- An Integrated In Vitro–In Silico Approach for Silver Nanoparticle Dosimetry in Cell Cultures
- (2020) Daniele Poli et al. ANNALS OF BIOMEDICAL ENGINEERING
- Transient FOXO1 inhibition in pancreatic endoderm promotes the generation of NGN3+ endocrine precursors from human iPSCs
- (2020) Ben Sasaki et al. Stem Cell Research
- Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
- (2020) Aditya Mithal et al. Nature Communications
- Pancreatic cancer-derived organoids – a disease modeling tool to predict drug response
- (2020) Pierre-Olivier Frappart et al. United European Gastroenterology Journal
- Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
- (2020) Junxiong Pang et al. Journal of Clinical Medicine
- Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa
- (2020) Mei-Ling Gao et al. Frontiers in Cell and Developmental Biology
- Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles
- (2020) Parikshit Moitra et al. ACS Nano
- Diagnosing COVID-19: The Disease and Tools for Detection
- (2020) Buddhisha Udugama et al. ACS Nano
- Toxicity and Gene Expression Profiling of Copper- and Titanium-Based Nanoparticles Using Air–Liquid Interface Exposure
- (2020) Matthias Hufnagel et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Generation of Genetically Engineered Mouse Lung Organoid Models for Squamous Cell Lung Cancers Allows for the Study of Combinatorial Immunotherapy
- (2020) Josephine Hai et al. CLINICAL CANCER RESEARCH
- Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease
- (2020) Minakshi Prasad et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Insight into Nanomedicinal Approaches to Combat Viral Zoonoses
- (2020) Minakshi Prasad et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs
- (2020) Ali Kermanizadeh et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
- Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders
- (2020) Augustin Chen et al. Frontiers in Cellular Neuroscience
- Construction of a web-based nanomaterial database by big data curation and modeling friendly nanostructure annotations
- (2020) Xiliang Yan et al. Nature Communications
- Retinal Organoids derived from hiPSCs of an AIPL1-LCA Patient Maintain Cytoarchitecture despite Reduced levels of Mutant AIPL1
- (2020) Dunja Lukovic et al. Scientific Reports
- Generation of intestinal organoids derived from human pluripotent stem cells for drug testing
- (2020) Shinpei Yoshida et al. Scientific Reports
- Fabrication of Perfusable Vascular Channels and Capillaries in 3D Liver-like Tissue
- (2020) Nobuhito Mori et al. Scientific Reports
- Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array
- (2020) Raphaël F.-X. Tomasi et al. Cell Reports
- Organoids as a Powerful Model for Respiratory Diseases
- (2020) Yu Li et al. Stem Cells International
- A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering
- (2020) Haitao Liu et al. Advanced Science
- Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review
- (2020) Asim Ali Yaqoob et al. Frontiers in Chemistry
- Synthetic alternatives to Matrigel
- (2020) Elizabeth A. Aisenbrey et al. Nature Reviews Materials
- Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation
- (2020) Flavio Dormont et al. Science Advances
- Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
- (2020) Dylan J. Richards et al. Nature Biomedical Engineering
- Tissue Engineering Using Vascular Organoids From Human Pluripotent Stem Cell Derived Mural Cell Phenotypes
- (2020) Maria Markou et al. Frontiers in Bioengineering and Biotechnology
- State-of-Art Bio-Assay Systems and Electrochemical Approaches for Nanotoxicity Assessment
- (2020) Ravikumar B. Shinde et al. Frontiers in Bioengineering and Biotechnology
- A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma—Toward a Better Mimicry of the in vivo Tumor Microenvironment
- (2020) Priyanka Gupta et al. Frontiers in Bioengineering and Biotechnology
- Nanotechnology for COVID-19: Therapeutics and Vaccine Research
- (2020) Gaurav Chauhan et al. ACS Nano
- 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment
- (2020) Aida Rodriguez-Garcia et al. ADVANCES IN POLYMER TECHNOLOGY
- 3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo
- (2020) Silvia Velasco et al. Annual Review of Neuroscience
- Liver progenitor cell-driven liver regeneration
- (2020) Juhoon So et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Modeling neoplastic disease with spheroids and organoids
- (2020) Michele Zanoni et al. Journal of Hematology & Oncology
- The importance of spheroids in analyzing nanomedicine efficacy
- (2020) Inês Mó et al. Nanomedicine
- Hair-bearing human skin generated entirely from pluripotent stem cells
- (2020) Jiyoon Lee et al. NATURE
- Dexamethasone nanomedicines for COVID-19
- (2020) Twan Lammers et al. Nature Nanotechnology
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- (2020) Matthew D. Shin et al. Nature Nanotechnology
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- (2020) Jihoon Kim et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
- (2020) Jesse H. Erasmus et al. Science Translational Medicine
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- (2020) Xing Xiao et al. OncoTargets and Therapy
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- (2020) Giovanni Sorrentino et al. Nature Communications
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- (2020) Leo Benning et al. Scientific Reports
- Nanoparticle Toxicology
- (2020) Wen Yang et al. Annual Review of Pharmacology and Toxicology
- Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important Application
- (2020) Kamila Białkowska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Reality check for organoids in neuroscience
- (2020) Vivien Marx NATURE METHODS
- Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids
- (2020) Brooke Schuster et al. Nature Communications
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- (2020) Viktoriya Sokolova et al. Scientific Reports
- Microtechnology-based methods for organoid models
- (2020) Vanessa Velasco et al. Microsystems & Nanoengineering
- The Application of Brain Organoids: From Neuronal Development to Neurological Diseases
- (2020) Yikai Shou et al. Frontiers in Cell and Developmental Biology
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- (2020) Takeshi K. Matsui et al. Frontiers in Cellular Neuroscience
- A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth
- (2020) Vivek V Thacker et al. eLife
- Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
- (2020) Florian Tran et al. Frontiers in Immunology
- 3D Tumor Models and Their Use for the Testing of Immunotherapies
- (2020) Nicolas Boucherit et al. Frontiers in Immunology
- Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy
- (2020) Eliane Klein et al. Frontiers in Oncology
- Human blood vessel organoids as a model of diabetic vasculopathy
- (2019) Reiner A. Wimmer et al. NATURE
- Generation of lung organoids from human pluripotent stem cells in vitro
- (2019) Alyssa J. Miller et al. Nature Protocols
- Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions
- (2019) Julia Y. Co et al. Cell Reports
- Tubuloids derived from human adult kidney and urine for personalized disease modeling
- (2019) Frans Schutgens et al. NATURE BIOTECHNOLOGY
- Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine
- (2019) Domenico Lombardo et al. Journal of Nanomaterials
- Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications
- (2019) Idit Goldfracht et al. Acta Biomaterialia
- Formation of organotypic testicular organoids in microwell culture†
- (2019) Sadman Sakib et al. BIOLOGY OF REPRODUCTION
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- (2019) Ricardo Cruz-Acuña et al. EXPERIMENTAL CELL RESEARCH
- Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids
- (2019) Sangbae Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding Nanoparticle Toxicity Mechanisms To Inform Redesign Strategies To Reduce Environmental Impact
- (2019) Joseph T. Buchman et al. ACCOUNTS OF CHEMICAL RESEARCH
- Nano-antimicrobials: A new paradigm for combating mycobacterial resistance
- (2019) Prasad Minakshi et al. CURRENT PHARMACEUTICAL DESIGN
- Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids
- (2019) Seon Ju Mun et al. JOURNAL OF HEPATOLOGY
- Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery
- (2019) Paulo Emílio Corrêa Leite et al. Particle and Fibre Toxicology
- The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
- (2019) Ali Kermanizadeh et al. Scientific Reports
- Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
- (2019) Kevin Achberger et al. eLife
- Engineered materials for organoid systems
- (2019) Michael J. Kratochvil et al. Nature Reviews Materials
- The hurdles of nanotoxicity in transplant nanomedicine
- (2019) Amber Nagy et al. Nanomedicine
- Engineering of human brain organoids with a functional vascular-like system
- (2019) Bilal Cakir et al. NATURE METHODS
- Generation of blood vessel organoids from human pluripotent stem cells
- (2019) Reiner A. Wimmer et al. Nature Protocols
- Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
- (2019) Ali Kermanizadeh et al. Particle and Fibre Toxicology
- Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
- (2019) Minsuh Kim et al. Nature Communications
- Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo
- (2019) Matthew J. Brooks et al. Stem Cell Reports
- Evaluation of Spheroid 3D Culture Methods to Study a Pancreatic Neuroendocrine Neoplasm Cell Line
- (2019) Giulia Bresciani et al. Frontiers in Endocrinology
- Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities
- (2019) Juliana Minardi Nascimento et al. Frontiers in Cell and Developmental Biology
- Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond
- (2019) Priyanka Tharkar et al. Frontiers in Bioengineering and Biotechnology
- Human brain development through the lens of cerebral organoid models
- (2019) Madeline G. Andrews et al. BRAIN RESEARCH
- Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation
- (2019) Shafiq M. Syed et al. Cell Stem Cell
- Skin Toxicity Assessment of Silver Nanoparticles in a 3D Epidermal Model Compared to 2D Keratinocytes
- (2019) Liang Chen et al. International Journal of Nanomedicine
- Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease
- (2019) Rebecca M. Marton et al. TRENDS IN CELL BIOLOGY
- Stem cell-based retina models
- (2018) Kevin Achberger et al. ADVANCED DRUG DELIVERY REVIEWS
- Engineering innervated secretory epithelial organoids by magnetic three-dimensional bioprinting for stimulating epithelial growth in salivary glands
- (2018) Christabella Adine et al. BIOMATERIALS
- Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world
- (2018) Minakshi Prasad et al. BIOMEDICINE & PHARMACOTHERAPY
- Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
- (2018) Daichi Onozato et al. DRUG METABOLISM AND DISPOSITION
- Human brain organoid-on-a-chip to model prenatal nicotine exposure
- (2018) Yaqing Wang et al. LAB ON A CHIP
- An in vivo model of functional and vascularized human brain organoids
- (2018) Abed AlFatah Mansour et al. NATURE BIOTECHNOLOGY
- Generation of human brain region–specific organoids using a miniaturized spinning bioreactor
- (2018) Xuyu Qian et al. Nature Protocols
- Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates
- (2018) James K. Carrow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
- (2018) Georgios Vlachogiannis et al. SCIENCE
- Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency
- (2018) Dean Hallam et al. STEM CELLS
- Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions
- (2018) Sabine U Vorrink et al. TOXICOLOGICAL SCIENCES
- Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract
- (2018) Wyatt Lanik et al. Viruses-Basel
- Progress and challenges towards targeted delivery of cancer therapeutics
- (2018) Daniel Rosenblum et al. Nature Communications
- Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
- (2018) Jaison Jeevanandam et al. Beilstein Journal of Nanotechnology
- Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles
- (2018) Min Zheng et al. Scientific Reports
- Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids
- (2018) Jiyoon Lee et al. Cell Reports
- Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids
- (2018) Priya Srikanth et al. Translational Psychiatry
- Human testicular organoid system as a novel tool to study Zika virus pathogenesis
- (2018) Daniel P. Strange et al. Emerging Microbes & Infections
- Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization
- (2018) Susan Hua et al. Frontiers in Pharmacology
- Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients
- (2018) Wen-Li Deng et al. Stem Cell Reports
- Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential
- (2018) Cindy J.M. Loomans et al. Stem Cell Reports
- Organoids for Drug Discovery and Personalized Medicine
- (2018) Toshio Takahashi Annual Review of Pharmacology and Toxicology
- Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold
- (2018) Soon Seng Ng et al. BIOMATERIALS
- Organoid technology and applications in cancer research
- (2018) Hanxiao Xu et al. Journal of Hematology & Oncology
- Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
- (2018) William J. Zacharias et al. NATURE
- A Three-Dimensional Organoid Culture Model to Assess the Influence of Chemicals on Morphogenetic Fusion
- (2018) David G Belair et al. TOXICOLOGICAL SCIENCES
- A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma
- (2018) Duangporn Saengwimol et al. Scientific Reports
- Nano based drug delivery systems: recent developments and future prospects
- (2018) Jayanta Kumar Patra et al. JOURNAL OF NANOBIOTECHNOLOGY
- Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study
- (2018) Konstantinos I. Votanopoulos et al. ANNALS OF SURGICAL ONCOLOGY
- Evaluation of variability in human kidney organoids
- (2018) Belinda Phipson et al. NATURE METHODS
- 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
- (2018) Lorna J. Hale et al. Nature Communications
- Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
- (2018) Jong Min Lee et al. Scientific Reports
- Magneto-nanosensor smartphone platform for the detection of HIV and leukocytosis at point-of-care
- (2018) Elaine Ng et al. Nanomedicine-Nanotechnology Biology and Medicine
- Nanomedicines: The magic bullets reaching their target?
- (2018) Beat Flühmann et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- High-throughput single-cell transcriptomics on organoids
- (2018) Agnieska Brazovskaja et al. CURRENT OPINION IN BIOTECHNOLOGY
- Intestinal organoids containing poly(lactic-co -glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases
- (2017) Zahra Davoudi et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- In situ generation of human brain organoids on a micropillar array
- (2017) Yujuan Zhu et al. LAB ON A CHIP
- Cell diversity and network dynamics in photosensitive human brain organoids
- (2017) Giorgia Quadrato et al. NATURE
- A three-dimensional model of human lung development and disease from pluripotent stem cells
- (2017) Ya-Wen Chen et al. NATURE CELL BIOLOGY
- Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
- (2017) Miguel Crespo et al. NATURE MEDICINE
- The use of brain organoids to investigate neural development and disease
- (2017) Elizabeth Di Lullo et al. NATURE REVIEWS NEUROSCIENCE
- Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines
- (2017) Gianpiero Lazzari et al. Polymer Chemistry
- Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells
- (2017) Mingxing Lei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
- (2017) Arun Sharma et al. Science Translational Medicine
- Chemically-induced photoreceptor degeneration and protection in mouse iPSC-derived three-dimensional retinal organoids
- (2017) Shin-ichiro Ito et al. Stem Cell Research
- Assessment of the toxicity and inflammatory effects of different-sized zinc oxide nanoparticles in 2D and 3D cell cultures
- (2017) Zhipan Wu et al. RSC Advances
- Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
- (2017) Momoko Watanabe et al. Cell Reports
- Experimental study of tuberculosis: From animal models to complex cell systems and organoids
- (2017) Kaori L. Fonseca et al. PLoS Pathogens
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- (2017) Zhihao Liu et al. Frontiers in Pharmacology
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- (2017) Rahim Dad Brohi et al. Frontiers in Pharmacology
- Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties
- (2017) Yoni Baert et al. Stem Cell Reports
- High-Content Monitoring of Drug Effects in a 3D Spheroid Model
- (2017) Frédérique Mittler et al. Frontiers in Oncology
- Human engineered heart tissue as a model system for drug testing
- (2016) Alexandra Eder et al. ADVANCED DRUG DELIVERY REVIEWS
- 2D and 3D cell cultures – a comparison of different types of cancer cell cultures
- (2016) Marta Kapałczyńska et al. Archives of Medical Science
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- (2016) Xuyu Qian et al. CELL
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- (2016) Junghyun Jo et al. Cell Stem Cell
- Cell spheroids: the new frontiers in in vitro models for cancer drug validation
- (2016) Maria Chatzinikolaidou DRUG DISCOVERY TODAY
- Building pancreatic organoids to aid drug development
- (2016) Edgar S Wills et al. GUT
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- (2016) Meike Hohwieler et al. GUT
- Nanotoxicity: emerging concerns regarding nanomaterial safety and occupational hard metal (WC-Co) nanoparticle exposure
- (2016) Andrea L Armstead et al. International Journal of Nanomedicine
- Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung
- (2016) Otmar Schmid et al. JOURNAL OF AEROSOL SCIENCE
- Critical review of the current and future challenges associated with advancedin vitrosystems towards the study of nanoparticle (secondary) genotoxicity
- (2016) Stephen J. Evans et al. MUTAGENESIS
- A combined proteomics and metabolomics approach to assess the effects of gold nanoparticlesin vitro
- (2016) Sabrina Gioria et al. Nanotoxicology
- Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
- (2016) Johanna F. Dekkers et al. Science Translational Medicine
- An Early-Stage Atherosclerosis Research Model Based on Microfluidics
- (2016) Wenfu Zheng et al. Small
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- (2016) Xun Luo et al. Scientific Reports
- Zebrafish: A complete animal model to enumerate the nanoparticle toxicity
- (2016) Chiranjib Chakraborty et al. JOURNAL OF NANOBIOTECHNOLOGY
- Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures
- (2016) Mehriban Ulusoy et al. Toxicology Research
- High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform
- (2016) Gregory J. Nierode et al. Stem Cell Reports
- Skin-on-a-chip model simulating inflammation, edema and drug-based treatment
- (2016) Maierdanjiang Wufuer et al. Scientific Reports
- Nanotoxicity of Silver Nanoparticles to Red Blood Cells: Size Dependent Adsorption, Uptake, and Hemolytic Activity
- (2015) Li Qiang Chen et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects
- (2015) Edouard Alphandéry et al. Expert Review of Anticancer Therapy
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- (2015) Luis Guillermo Garduño-Balderas et al. JOURNAL OF APPLIED TOXICOLOGY
- Pumpless microfluidic platform for drug testing on human skin equivalents
- (2015) Hasan Erbil Abaci et al. LAB ON A CHIP
- Nanotoxicology: advances and pitfalls in research methodology
- (2015) Morteza Azhdarzadeh et al. Nanomedicine
- An intestinal Trojan horse for gene delivery
- (2015) Haisheng Peng et al. Nanoscale
- Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
- (2015) Minoru Takasato et al. NATURE
- Nephron organoids derived from human pluripotent stem cells model kidney development and injury
- (2015) Ryuji Morizane et al. NATURE BIOTECHNOLOGY
- Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)
- (2015) John W. Wills et al. Particle and Fibre Toxicology
- Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types
- (2015) Kimberly R. Doherty et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
- (2015) Hideya Sakaguchi et al. Nature Communications
- Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells
- (2015) Keiko Muguruma et al. Cell Reports
- In vitro generation of human pluripotent stem cell derived lung organoids
- (2015) Briana R Dye et al. eLife
- An overview of nanotoxicity and nanomedicine research: principles, progress and implications for cancer therapy
- (2015) Ye Wang et al. Journal of Materials Chemistry B
- Neural Cell Chip Based Electrochemical Detection of Nanotoxicity
- (2015) Md. Kafi et al. Nanomaterials
- Biological Responses to Engineered Nanomaterials: Needs for the Next Decade
- (2015) Catherine J. Murphy et al. ACS Central Science
- Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure
- (2015) Esther L. Calderon-Gierszal et al. PLoS One
- Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications
- (2015) Anurag Mathur et al. Scientific Reports
- Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments
- (2014) Anna Astashkina et al. ADVANCED DRUG DELIVERY REVIEWS
- Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue
- (2014) Alexandra Eder et al. BASIC RESEARCH IN CARDIOLOGY
- Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model
- (2014) Anna I. Astashkina et al. BIOMATERIALS
- RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction
- (2014) Rachael M. Liesman et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms of nanotoxicity: Generation of reactive oxygen species
- (2014) Peter P. Fu et al. JOURNAL OF FOOD AND DRUG ANALYSIS
- Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
- (2014) Mandy B. Esch et al. LAB ON A CHIP
- Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
- (2014) Kyle W. McCracken et al. NATURE
- Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release
- (2014) Anda R Gliga et al. Particle and Fibre Toxicology
- Biomimicry 3D Gastrointestinal Spheroid Platform for the Assessment of Toxicity and Inflammatory Effects of Zinc Oxide Nanoparticles
- (2014) Sing Ling Chia et al. Small
- Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT)
- (2014) Thalita B. Zanoni et al. TOXICOLOGY LETTERS
- The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress
- (2014) Yun-Ching Chang et al. Frontiers in Aging Neuroscience
- Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations
- (2014) Manzoor Ahmad Gatoo et al. Biomed Research International
- In Vivo Biodistribution and Toxicology of Carboxylated Graphene Quantum Dots
- (2013) Md Nurunnabi et al. ACS Nano
- Extensive evaluations of the cytotoxic effects of gold nanoparticles
- (2013) Show-Mei Chuang et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap
- (2013) Freya Joris et al. CHEMICAL SOCIETY REVIEWS
- Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity
- (2013) Ping Liang et al. CIRCULATION
- Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications
- (2013) Larissa Y Rizzo et al. CURRENT OPINION IN BIOTECHNOLOGY
- Localized Argyria Caused by Metallic Silver Aortic Grafts: A Unique Adverse Effect
- (2013) P. Berger et al. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
- Vascularized and functional human liver from an iPSC-derived organ bud transplant
- (2013) Takanori Takebe et al. NATURE
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential
- (2013) Xiang Wang et al. Small
- Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
- (2013) Kimberly R. Doherty et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
- (2013) Radina Kostadinova et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing
- (2013) H Vörsmann et al. Cell Death & Disease
- Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
- (2013) Alexandre Albanese et al. Nature Communications
- Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans
- (2013) Abhinav Bhushan et al. Stem Cell Research & Therapy
- Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
- (2012) Motao Zhu et al. ACCOUNTS OF CHEMICAL RESEARCH
- Engineering fibrotic tissue in pancreatic cancer: A novel three-dimensional model to investigate nanoparticle delivery
- (2012) Hitomi Hosoya et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays
- (2012) Anna I. Astashkina et al. BIOMATERIALS
- Carbon nanomaterials for electronics, optoelectronics, photovoltaics, and sensing
- (2012) Deep Jariwala et al. CHEMICAL SOCIETY REVIEWS
- Self-formation of functional adenohypophysis in three-dimensional culture
- (2011) Hidetaka Suga et al. NATURE
- Baseline Values of Candidate Urine Acute Kidney Injury Biomarkers Vary by Gestational Age in Premature Infants
- (2011) David J Askenazi et al. PEDIATRIC RESEARCH
- Nanotoxicology and in vitro studies: The need of the hour
- (2011) Sumit Arora et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells
- (2011) Anna Lankoff et al. TOXICOLOGY LETTERS
- Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
- (2010) Nick Barker et al. Cell Stem Cell
- Drug delivery and nanoparticles: Applications and hazards
- (2010) de Jong International Journal of Nanomedicine
- Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
- (2010) Frank Dieterle et al. NATURE BIOTECHNOLOGY
- Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
- (2010) Karin S Hougaard et al. Particle and Fibre Toxicology
- In vitro assessments of nanomaterial toxicity
- (2009) Clinton F. Jones et al. ADVANCED DRUG DELIVERY REVIEWS
- Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
- (2009) Sophie Laurent et al. CHEMICAL REVIEWS
- The future of drug safety testing: expanding the view and narrowing the focus
- (2009) James L. Stevens et al. DRUG DISCOVERY TODAY
- A microfluidic 3D hepatocyte chip for drug toxicity testing
- (2009) Yi-Chin Toh et al. LAB ON A CHIP
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
- (2009) Toshiro Sato et al. NATURE
- Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
- (2009) Akifumi Ootani et al. NATURE MEDICINE
- In vitro Toxicity Testing of Nanoparticles in 3D Cell Culture
- (2009) Jungwoo Lee et al. Small
- In vivo Quantum-Dot Toxicity Assessment
- (2009) Tanya S. Hauck et al. Small
- Are In Vitro Tests Suitable for Regulatory Use?
- (2009) Thomas Hartung et al. TOXICOLOGICAL SCIENCES
- Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
- (2009) Eun-Jung Park et al. TOXICOLOGY IN VITRO
- Nanoparticles: Their potential toxicity, waste and environmental management
- (2009) Grazyna Bystrzejewska-Piotrowska et al. WASTE MANAGEMENT
- Assessing nanotoxicity in cells in vitro
- (2009) Jedd M. Hillegass et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
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