An in vivo model of functional and vascularized human brain organoids

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

(2017) Yuchen Qi et al.   NATURE BIOTECHNOLOGY

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

(2017) Jatin Roper et al.   NATURE BIOTECHNOLOGY

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

(2017) Kevin P O'Rourke et al.   NATURE BIOTECHNOLOGY

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Transplanted embryonic neurons integrate into adult neocortical circuits

(2016) Susanne Falkner et al.   NATURE

In vivo imaging of dendritic pruning in dentate granule cells

(2016) J Tiago Gonçalves et al.   NATURE NEUROSCIENCE

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

(2016) Jerome Mertens et al.   NATURE REVIEWS NEUROSCIENCE

Sensitive red protein calcium indicators for imaging neural activity

(2016) Hod Dana et al.   eLife

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Clinical translation of stem cell transplantation in Parkinson's disease

(2015) O. Lindvall   JOURNAL OF INTERNAL MEDICINE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Cell-based therapies for Parkinson disease—past insights and future potential

(2015) Roger A. Barker et al.   Nature Reviews Neurology

Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells

(2015) Lachlan H. Thompson et al.   NEUROBIOLOGY OF DISEASE

Moving Stem Cells to the Clinic: Potential and Limitations for Brain Repair

(2015) Julius A. Steinbeck et al.   NEURON

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

(2015) Shane Grealish et al.   Stem Cell Reports

hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice

(2014) Miles Cunningham et al.   Cell Stem Cell

Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance

(2014) A. A. Mansour et al.   DEVELOPMENT

Cerebellar-Dependent Expression of Motor Learning during Eyeblink Conditioning in Head-Fixed Mice

(2014) S. A. Heiney et al.   JOURNAL OF NEUROSCIENCE

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

(2014) Xin Jin et al.   NATURE NEUROSCIENCE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Regenerative medicine in Huntington's disease: Current status on fetal grafts and prospects for the use of pluripotent stem cell

(2014) A.-C. Bachoud-Lévi et al.   REVUE NEUROLOGIQUE

Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

(2014) Juthaporn Assawachananont et al.   Stem Cell Reports

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Circuit level defects in the developing neocortex of Fragile X mice

(2013) J Tiago Gonçalves et al.   NATURE NEUROSCIENCE

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr5+ liver stem cells, hepatic organoids and regenerative medicine

(2013) Meritxell Huch et al.   Regenerative Medicine

In vitro organogenesis in three dimensions: self-organising stem cells

(2012) Y. Sasai et al.   DEVELOPMENT

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Start/stop signals emerge in nigrostriatal circuits during sequence learning

(2010) Xin Jin et al.   NATURE

Internally Mediated Developmental Desynchronization of Neocortical Network Activity

(2009) P. Golshani et al.   JOURNAL OF NEUROSCIENCE

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE