Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing

Utilizing comparative models in biomedical research

(2021) Alexander G. Little et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

An Integrated In Vitro–In Silico Approach for Silver Nanoparticle Dosimetry in Cell Cultures

(2020) Daniele Poli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

(2020) Stephan Couderq et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nanotoxicology data for in silico tools: a literature review

(2020) Irini Furxhi et al.   Nanotoxicology

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

(2020) Sivakumar Murugadoss et al.   Particle and Fibre Toxicology

Nanotechnology in agriculture: Current status, challenges and future opportunities

(2020) Muhammad Usman et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments

(2020) Shigeto Kawai et al.   Scientific Reports

Nanotechnologies in Food Science: Applications, Recent Trends, and Future Perspectives

(2020) Shivraj Hariram Nile et al.   Nano-Micro Letters

Practices and Trends of Machine Learning Application in Nanotoxicology

(2020) Irini Furxhi et al.   Nanomaterials

It’s Time to Reconsider The Principles of Humane Experimental Technique

(2020) Michael Balls   ATLA-ALTERNATIVES TO LABORATORY ANIMALS

Concentration-dependent toxicogenomic changes of silver nanoparticles in hepatocyte-like cells derived from human induced pluripotent stem cells

(2020) Xiugong Gao et al.   CELL BIOLOGY AND TOXICOLOGY

Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes

(2020) Yujie Li et al.   International Journal of Nanomedicine

ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability

(2020) Gabriela Falcón-Cano et al.   Journal of Chemical Information and Modeling

A combination of experimental and computational methods to study the reactions during a Lignin-First approach

(2020) Ivan Kumaniaev et al.   PURE AND APPLIED CHEMISTRY

Construction of a web-based nanomaterial database by big data curation and modeling friendly nanostructure annotations

(2020) Xiliang Yan et al.   Nature Communications

AutoGrow4: an open-source genetic algorithm for de novo drug design and lead optimization

(2020) Jacob O. Spiegel et al.   Journal of Cheminformatics

EDock: blind protein–ligand docking by replica-exchange monte carlo simulation

(2020) Wenyi Zhang et al.   Journal of Cheminformatics

Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals

(2020) Risa R. Sayre et al.   Scientific Data

A novel human pluripotent stem cell-based assay to predict developmental toxicity

(2020) Karin Lauschke et al.   ARCHIVES OF TOXICOLOGY

Cytochrome P450 inhibition potential and initial genotoxic evaluation of 14-O-[(4,6-diaminopyrimidine-2-yl)thioacetyl] mutilin

(2020) Yunxing Fu et al.   Scientific Reports

Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine

(2020) Ajay Vikram Singh et al.   Advanced Healthcare Materials

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective

(2020) Dania Movia et al.   Frontiers in Bioengineering and Biotechnology

In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM

(2020) Noemi Angeles Durán-Iturbide et al.   ACS Omega

Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells

(2020) Simon Lagies et al.   Communications Biology

3D printing tissue-mimicking materials for realistic transseptal puncture models

(2020) Lindsey B. Bezek et al.   Journal of the Mechanical Behavior of Biomedical Materials

Ethics of research on stem cells and regenerative medicine: ethical guidelines in the Islamic Republic of Iran

(2020) Leila Afshar et al.   Stem Cell Research & Therapy

Computational Approaches in Preclinical Studies on Drug Discovery and Development

(2020) Fengxu Wu et al.   Frontiers in Chemistry

Capsaicin-loaded solid lipid nanoparticles: design, biodistribution, in silico modeling and in vitro cytotoxicity evaluation

(2020) Selvaraj Kunjiappan et al.   NANOTECHNOLOGY

Interaction of nanoparticles with biological macromolecules: a review of molecular docking studies

(2020) Abdallah S. Abdelsattar et al.   Nanotoxicology

The activity of methacrylate esters in skin sensitisation test methods II. A review of complementary and additional analyses

(2020) Ian Kimber   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Are atranols the only skin sensitizers in oakmoss? A systematic investigation using non-animal methods

(2020) Cristina Avonto et al.   TOXICOLOGY IN VITRO

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer

(2019) Styliani Melissaridou et al.   Cancer Cell International

Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

(2019) Ajay Vikram Singh et al.   TOXICOLOGY MECHANISMS AND METHODS

Stem cells: past, present, and future

(2019) Wojciech Zakrzewski et al.   Stem Cell Research & Therapy

2D- and 3D-QSAR modelling, molecular docking and in vitro evaluation studies on 18β-glycyrrhetinic acid derivatives against triple-negative breast cancer cell line

(2019) Aparna Shukla et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Towards an alternative to nano-QSAR for nanoparticle toxicity ranking in case of small datasets

(2019) Valérie Forest et al.   JOURNAL OF NANOPARTICLE RESEARCH

Application of Bayesian networks in determining nanoparticle-induced cellular outcomes using transcriptomics

(2019) Irini Furxhi et al.   Nanotoxicology

A Magnesium‐Enriched 3D Culture System that Mimics the Bone Development Microenvironment for Vascularized Bone Regeneration

(2019) Sihan Lin et al.   Advanced Science

Understanding the Chemical Nature of Nanoparticle–Protein Interactions

(2019) Didar Baimanov et al.   BIOCONJUGATE CHEMISTRY

Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data

(2019) Kirsten Rasmussen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Open-source QSAR models for pKa prediction using multiple machine learning approaches

(2019) Kamel Mansouri et al.   Journal of Cheminformatics

Recent advances and applications of machine learning in solid-state materials science

(2019) Jonathan Schmidt et al.   npj Computational Materials

In Silico Design of Novel Tetra-Substituted Pyridinylimidazoles Derivatives as c-Jun N-Terminal Kinase-3 Inhibitors, Using 2D/3D-QSAR Studies, Molecular Docking and ADMET Prediction

(2019) Abdellah El Aissouq et al.   International Journal of Peptide Research and Therapeutics

Molecular Docking as a Promising Predictive Model for Silver Nanoparticle-Mediated Inhibition of Cytochrome P450 Enzymes

(2019) Nootcharin Wasukan et al.   Journal of Chemical Information and Modeling

Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance

(2019) Julia C. Fontoura et al.   Materials Science & Engineering C-Materials for Biological Applications

Nano-(Q)SAR for Cytotoxicity Prediction of Engineered Nanomaterials

(2019) Andrey A. Buglak et al.   MOLECULES

Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling

(2019) Nipha Chaicharoenaudomrung et al.   World Journal of Stem Cells

Ethical and Safety Issues of Stem Cell-Based Therapy

(2018) Vladislav Volarevic et al.   International Journal of Medical Sciences

Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)

(2018) Jung-Pan Wang et al.   PLoS One

Pluripotent Stem Cells in Developmental Toxicity Testing: A Review of Methodological Advances

(2018) Anthony L Luz et al.   TOXICOLOGICAL SCIENCES

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications

(2018) Bou-Yue Peng et al.   Journal of Diabetes Research

Stem cells as delivery vehicles for regenerative medicine-challenges and perspectives

(2018) Luminita Labusca et al.   World Journal of Stem Cells

In silico models in drug development: where we are

(2018) Janet Piñero et al.   CURRENT OPINION IN PHARMACOLOGY

2D, 3D and Hybrid QSAR Studies of Nostoclide Analogues as Inhibitors of the Photosystem II

(2018) Pedro de Carvalho et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

MSC functionalization for enhanced therapeutic applications

(2018) Dimitrios Kouroupis et al.   TISSUE ENGINEERING PART B-REVIEWS

Toxicity Classification of Oxide Nanomaterials: Effects of Data Gap Filling and PChem Score-based Screening Approaches

(2018) My Kieu Ha et al.   Scientific Reports

Stem cells as therapy for heart disease: iPSCs, ESCs, CSCs, and skeletal myoblasts

(2018) Reza Rikhtegar et al.   BIOMEDICINE & PHARMACOTHERAPY

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

(2018) Ana S. Nunes et al.   BIOTECHNOLOGY AND BIOENGINEERING

Embryonic stem cells and the next generation of developmental toxicity testing

(2017) Josephine Kugler et al.   Expert Opinion on Drug Metabolism & Toxicology

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

(2017) Malgorzata Kucinska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Inhibitors or toxins? Large library target-specific screening of fullerene-based nanoparticles for drug design purpose

(2017) Lucky Ahmed et al.   Nanoscale

Alternative approach to animal testing and cell cultures, according to European laws

(2017) Chiara Scanarotti   ALTEX-Alternatives to Animal Experimentation

Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project

(2017) Ronald de Hoogt et al.   Scientific Data

2D and 3D cell cultures – a comparison of different types of cancer cell cultures

(2016) Marta Kapałczyńska et al.   Archives of Medical Science

Study of nanoparticles aggregation/agglomeration in polymer particulate nanocomposites by mechanical properties

(2016) Yasser Zare   COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING

Stem cell therapy for acute respiratory distress syndrome

(2016) Shahd Horie et al.   Current Opinion in Critical Care

Pluripotent stem cells: Anin vitromodel for nanotoxicity assessments

(2016) Harish K. Handral et al.   JOURNAL OF APPLIED TOXICOLOGY

An Overview of Tissue Engineering as an Alternative for Toxicity Assessment

(2016) Mathew Garrod et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Alternatives to animal testing: A review

(2015) Sonali K. Doke et al.   SAUDI PHARMACEUTICAL JOURNAL

Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens

(2015) Yamilé López Hernández et al.   Frontiers in Microbiology

Statistical analysis of production of protease and esterase by a newly isolated Lysinibacillus fusiformis AU01: purification and application of protease in sub-culturing cell lines

(2014) M Suryia Prabha et al.   ANNALS OF MICROBIOLOGY

Mechanisms of nanotoxicity: Generation of reactive oxygen species

(2014) Peter P. Fu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Cell-based therapy approaches: the hope for incurable diseases

(2014) Ella Buzhor et al.   Regenerative Medicine

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Quantitative Nanostructure−Activity Relationship Modeling

(2010) Denis Fourches et al.   ACS Nano

3D-QSAR in Drug Design - A Review

(2010) Jitender Verma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biomaterials for stem cell differentiation

(2010) Anirudha Singh et al.   JOURNAL OF MATERIALS CHEMISTRY

Biomaterials for stem cell differentiation

(2007) Eileen Dawson et al.   ADVANCED DRUG DELIVERY REVIEWS